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Wytske Fokkens

Principal Investigator, PROF.DR.

 https://orcid.org/0000-0003-4852-229X
  • 57574
    Citations
1979 …2026

Research activity per year

Personal profile

Research interests

  Main field of interest is sinus and skull base surgery and mucosal pathology of the upper and lower airways.

Chronic Rhinosinusitis and Nasal Polyps: From epidemiology via system biology to new treatments.
Further to the GA2LEN network we will investigate differences in disease expression between ethnic groups in a cohort of 8000 patients and will further participate in the Helius study. We will identify disease mechanisms and develop new treatments for difficult to treat cases with some new options currently under evaluation. In a national multicenter trial we aim to compare efficacy of surgery versus medical treatment (ZonMw). The new possibilities of biologicals are investigated.

Non-allergic rhinitis: From pathophysiology to new treatments.
Around 10% of the European population suffers from NAR with effective treatment only available for few individuals as the aetiology is often unknown. Phenotyping NAR in a clinical and laboratory setting has led to a new treatment option, with a second in development together with pharmaceutical partners.

Allergic rhinitis: Towards personalized treatment
We have shown that different allergen sensitizations have different clinical outcomes that affects treatment in individual patients and corroborated this by laboratory studies. In an international IMI consortium (UBIOPRED) on severe lower respiratory diseases we will search for molecular handprints for the relationships of upper and lower airway and in a new EU trial (BM4SIT) we will evaluate personalized immunotherapy.

Specialisation

Rhinology

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • European Position Paper on Rhinosinusitis and Nasal Polyps 2020

    Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., Terezinha Anselmo-Lima, W., Bachert, C., Baroody, F., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., de Gabory, L., Desrosiers, M. & Diamant, Z. & 108 others, Douglas, R. G., Gevaert, P. H., Hafner, A., Harvey, R. J., Joos, G. F., Kalogjera, L., Knill, A., Kocks, J. H., Landis, B. N., Limpens, J., Lebeer, S., Lourenco, O., Matricardi, P. M., Meco, C., O Mahony, L., Philpott, C. M., Ryan, D., Schlosser, R., Senior, B., Smith, T. L., Teeling, T., Tomazic, P. V., Wang, D. Y., Wang, D., Zhang, L., Agius, A. M., Ahlstrom-Emanuelsson, C., Alabri, R., Albu, S., Alhabash, S., Aleksic, A., Aloulah, M., Al-Qudah, M., Alsaleh, S., Baban, M. A., Baudoin, T., Balvers, T., Battaglia, T., Bedoya, J. D., Beule, A., Bofares, K. M., Braverman, I., Brozek-Madry, E., Richard, B., Callejas, C., Carrie, S., Caulley, L., Chussi, D., de Corso, E., Coste, A., Devyani, L., el Hadi, U., Elfarouk, A., Eloy, P. H., Farrokhi, S., Felisati, G., Ferrari, M. D., Fishchuk, R., Grayson, W., Goncalves, P. M., Grdinic, B., Grgic, V., Hamizan, A. W., Heinichen, J. V., Husain, S., Ping, T. I., Ivaska, J., Jakimovska, F., Jovancevic, L., Kakande, E., Kamel, R., Karpischenko, S., Kariyawasam, H. H., Kjeldsen, A., Klimek, L., Kim, S. W., Letort, J. J., Lopatin, A., Mahdjoubi, A., Netkovski, J., Nyenbue Tshipukane, D., Obando-Valverde, A., Okano, M., Onerci, M., Ong, Y. K., Orlandi, R., Ouennoughy, K., Ozkan, M., Peric, A., Plzak, J., Prokopakis, E., Prepageran, N., Psaltis, A., Pugin, B., Raftopulos, M., Rombaux, P., Sahtout, S., Sarafoleanu, C. C., Searyoh, K., Rhee, C. S., Shi, J., Shkoukani, M., Shukuryan, A. K., Sicak, M., Smyth, D., Snidvongs, K., Soklic Kosak, T. & Stjarne, P., 20 Feb 2020, In: Rhinology. 58, p. 1-464 464 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • EUFOREA consensus on biologics for CRSwNP with or without asthma

    Fokkens, W. J., Lund, V., Bachert, C., Mullol, J., Bjermer, L., Bousquet, J., Canonica, G. W., Deneyer, L., Desrosiers, M., Diamant, Z., Han, J., Heffler, E., Hopkins, C., Jankowski, R., Joos, G., Knill, A., Lee, J., Lee, S. E., Mariën, G. & Pugin, B. & 3 others, Senior, B., Seys, S. F. & Hellings, P. W., Dec 2019, In: Allergy. 74, 12, p. 2312-2319

    Research output: Contribution to journal › Review article › Academic › peer-review

    Open Access
    File
    39 Downloads (Pure)

  • IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

    Bal, S. M., Bernink, J. H., Nagasawa, M., Groot, J., Shikhagaie, M. M., Golebski, K., van Drunen, C. M., Lutter, R., Jonkers, R. E., Hombrink, P., Bruchard, M., Villaudy, J., Munneke, J. M., Fokkens, W., Erjefält, J. S., Spits, H. & Ros, X. R., 2016, In: Nature immunology. 17, 6, p. 636-645

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    19 Downloads (Pure)

  • Avoid prescribing antibiotics in acute rhinosinusitis

    Fokkens, W. J., Hoffmans, R. & Thomas, M., 2014, In: BMJ (Clinical research ed.). 349, p. g5703

    Research output: Contribution to journal › Editorial › Academic › peer-review

  • Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials

    Bachert, C., Han, J. K., Desrosiers, M., Hellings, P. W., Amin, N., Lee, S. E., Mullol, J., Greos, L. S., Bosso, J. V., Laidlaw, T. M., Cervin, A. U., Maspero, J. F., Hopkins, C., Olze, H., Canonica, G. W., Paggiaro, P., Cho, S. H., Fokkens, W. J., Fujieda, S. & Zhang, M. & 14 others, Lu, X., Fan, C., Draikiwicz, S., Kamat, S. A., Khan, A., Pirozzi, G., Patel, N., Graham, N. M. H., Ruddy, M., Staudinger, H., Weinreich, D., Stahl, N., Yancopoulos, G. D. & Mannent, L. P., 2 Nov 2019, In: Lancet. 394, 10209, p. 1638-1650 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

View all 650 research outputs