Projects per year
Personal profile
Specialisation
Wilma van de Berg is senior translational and cellular neuroscientist, neuroanatomist, principal investigator and associate professor at dept. Anatomy and Neurosciences, head of the research section Clinical Neuroanatomy and Biobanking (CNAB), member of executive board of Advanced Optical Microscopy Core (www.ao2m.amsterdam) and lecturer in clinical neuroanatomy, neuropathology of movement disorders and clinical and translational neurosciences, Amsterdam UMC. She is an expert in human neuroanatomy, morphometry and 3D imaging (quantitaive MRI-to-pathology), and structural and cellular biology in Parkinson's disease and related neurodegenerative disorders. She is founder and director of the Normal Aging Brain Collection Amsterdam (www.nabca.eu), which collects advanced postmortem MRI and high-quality brain tissue of non-demented elderly for stimulating translational research in neurosciences since 2014.
Research interests
Her research over the years has focused on unravelling cellular mechanisms underpinning selective vulnerability, protein aggregation, clinical heterogeneity and disease progression in Parkinson’s disease and related neurodegenerative disorders. The knowledge on neuroanatomy, neuropathology, cellular disease mechanisms and human brain morphology in aging and disease is utilized to define novel MRI and biofluid biomarkers for improving early diagnosis and prediction of cognitive decline in Parkinson’s disease. She has gained experience in conducting clinical studies (e.g. PROGRESS-PD) in which Parkinson patients and age-matched controls were followed for eight years and identification of biofluid markers for disease progression in PD. She currently co-leads the longitudinal cohort ‘Profiling Parkinson’s’(ProPARK) and works closely together with clinical and industrie partners to identify molecular subtypes in Parkinson's disease. She is also partner in a large EU consortium, named NEUROCOV, which aims to unravel wich cell types are susceptible to SARS-CoV-2 infection and how damage occurs and what makes individualss vulnerable or resistant to such complications.
Education/Academic qualification
PhD, Cellular Neuroscience and Pediatrics, Maastricht University
Award Date: 12 Jun 2003
Master, Biological Health Sciences, Maastricht University, Maastricht, Netherlands
1 Sept 1993 → 30 Sept 2030
Award Date: 30 Sept 1998
External positions
President of Dutch Parkinson Scientists Association, Dutch Parkinson Scientists
… → 1 Apr 2024
Executive Board Parkinsonalliance Netherlands, Parkinsonalliance Netherlands
… → 26 Mar 2025
Keywords
- RZ Other systems of medicine
- QD Chemistry
- RB Pathology
- QM Human anatomy
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Unraveling the structural components of Lewy bodies in Parkinson's disease using high-end correlative optical and electron microscopy
van de Berg, W. (Principal investigator)
01/03/2018 → …
Project: Research
Research output
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies
Moors, T. E., Mona, D., Luehe, S., Duran-Pacheco, G., Spycher, L., Mundigl, O., Kaluza, K., Huber, S., Hug, M. N., Kremer, T., Ritter, M., Dziadek, S., Dernick, G., van de Berg, W. D. J. & Britschgi, M., 3 Jun 2022, In: Acta neuropathologica communications. 10, 1, 82.Research output: Contribution to journal › Article › Academic › peer-review
Open Access7 Citations (Scopus) -
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy
Moors, T. E., Maat, C. A., Niedieker, D., Mona, D., Petersen, D., Timmermans-Huisman, E., Kole, J., El-Mashtoly, S. F., Spycher, L., Zago, W., Barbour, R., Mundigl, O., Kaluza, K., Huber, S., Hug, M. N., Kremer, T., Ritter, M., Dziadek, S., Geurts, J. J. G. & Gerwert, K. & 2 others, , Sept 2021, In: Acta neuropathologica. 142, 3, p. 423-448 26 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access76 Citations (Scopus) -
Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
Shahmoradian, S. H., Lewis, A. J., Genoud, C., Hench, J. R., Moors, T. E., Navarro, P. P., Castaño-Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K. N., Sütterlin, R., Huisman, E., Ingrassia, A., Gier, Y. D., Rozemuller, A. J. M., Wang, J., Paepe, A. D., Erny, J., Staempfli, A. & Hoernschemeyer, J. & 13 others, , 2019, In: Nature neuroscience. 22, 7, p. 1099-1109Research output: Contribution to journal › Article › Academic › peer-review
655 Citations (Scopus) -
Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
Geut, H., Hepp, D. H., Foncke, E., Berendse, H. W., Rozemuller, J. M., Huitinga, I. & van de Berg, W. D. J., 26 Mar 2020, In: Acta neuropathologica communications. 8, 1, p. 39 1 p., 39.Research output: Contribution to journal › Article › Academic › peer-review
Open Access37 Citations (Scopus) -
CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson's Disease
Oosterveld, L. P., Kuiper, T. I., Majbour, N. K., Verberk, I. M. W., van Dijk, K. D., Twisk, J. W. R., El-Agnaf, O. M., Teunissen, C. E., Weinstein, H. C., Klein, M., Berendse, H. W. & van de Berg, W. D. J., 2 Nov 2020, In: International journal of molecular sciences. 21, 22, p. 1-12 12 p., 8519.Research output: Contribution to journal › Article › Academic › peer-review
8 Citations (Scopus)
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A picture is worth a thousand words: novel insights from multiscale imaging of protein assemblies in the Parkinsonian brain
van de Berg, W. (Speaker)
31 Aug 2022 → 2 Sept 2022Activity: Talk or presentation › Invited talk › Academic
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CSF biomarker panels reflecting disease mechanisms in Parkinsonian disorders
van de Berg, W. (Speaker)
30 Jun 2022Activity: Talk or presentation › Invited talk › Academic
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Tales of the human brain: multiscale imaging of Lewy body disease
van de Berg, W. (Speaker)
17 Jun 2022Activity: Talk or presentation › Invited talk › Academic
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Biological insights into Parkinson's disease heterogeneity
van de Berg, W. (Speaker)
31 Mar 2022Activity: Talk or presentation › Invited talk › Academic
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1st Annual Dutch Parkinson Scientists Congress 2021
van de Berg, W. (Chair)
29 Oct 2021Activity: Participating in or organising an event › organising
Prizes
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A picture is worth a thousand words: telling the tale of the Parkinson brain with correlative postmortem MRI and microscopy.
van de Berg, W. (Recipient), Jonkman, L. (Recipient), Berendse, H. (Recipient) & van der Werf, Y. (Recipient), 2019
Prize: Honorary award › Academic
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Press/Media
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VUmc persbericht
Hepp, D., van de Berg, W. & Schoonheim, M.
28/11/2017
1 Media contribution
Press/Media: publicengagement
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