Research output per year
Research output per year
Personal profile
Research interests
The aim of my research is to better understand the relation between brain network activity and cognitive impairment. Having been among the first to describe specific patterns of brain network damage in Alzheimer's disease (AD), during the past years I have developed a computational brain network model of AD. This approach helps to understand both the neurophysiological mechanism of the disease, and a recent insight is that it can also guide treatment selection by solving how to modulate abnormal brain activity in order to optimize network function. Modeling predictions will be tested in Alzheimer patients in the upcoming years using non-invasive brain stimulation.
Specialisation
Alzheimer's disease
Neurophysiology
EEG/MEG
Brain dynamics modeling
Grapht theory
Non-invasive brain stimulation
Related documents
Education/Academic qualification
PhD, In a network state of mind, VU University: -
Award Date: 7 Nov 2012
External positions
Senior Researcher, Amsterdam Neuroscience, Amsterdam, Netherlands
Keywords
- R Medicine (General)
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Network Hyperexcitability in Early-Stage Alzheimer's Disease: Evaluation of Functional Connectivity Biomarkers in a Computational Disease Model
Stam, C. J. & de Haan, W., 2024, In: Journal of Alzheimer s disease. 99, 4, p. 1333-1348 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile53 Downloads (Pure) -
A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing
van Nifterick, A. M., Gouw, A. A., van Kesteren, R. E., Scheltens, P., Stam, C. J. & de Haan, W., 1 Dec 2022, In: Alzheimer's Research and Therapy. 14, 1, 101.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile50 Downloads (Pure) -
Virtual neural network-guided optimization of non-invasive brain stimulation in Alzheimer's disease
Luppi, J. J., Stam, C. J., Scheltens, P. & de Haan, W., 1 Jan 2024, In: PLoS computational biology. 20, 1, e1011164.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile154 Downloads (Pure) -
Not as inert as assumed: Physical and perceptual characterization of a widely used rTMS sham coil
Woerdman, H. J., Steenkamp, S., de Haan, W., Hillebrand, A., van den Heuvel, O. A. & van der Werf, Y. D., 1 Nov 2026, In: Brain stimulation. 19, 6, p. 103210 103210.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open AccessFile -
Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility
van der A, J., Lodema, D. Y., van Dellen, E., Tendolkar, I., Emmelot-Vonk, M. H., Schutter, D. J. L. G., de Haan, W., van den Boogaard, M., Ottens, T. H. & Slooter, A. J. C., Sept 2026, In: Neurotherapeutics. 23, 5, p. e01037 e01037.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure)
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Translational Computational Modelling Relates AD Pathophysiology to Large-Scale Brain Dynamics
de Haan, W. (Invited speaker)
6 Sept 2022Activity: Talk or presentation › Invited talk › Academic
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NGN webinar - Geheugenpoli in tijden van Corona
Bakker, E. (Speaker) & de Haan, W. (Speaker)
4 Mar 2021Activity: Talk or presentation › Oral presentation › Academic
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Newcastle University, Newcastle upon Tyne, United Kingdom (External organisation)
de Haan, W. (Chair)
Nov 2020 → …Activity: Membership › Membership of committee › Academic
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Dutch Chapter of the Network Science Society (External organisation)
de Haan, W. (Chair)
2018 → 2021Activity: Membership › Membership of network › Professional
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Alzheimer Center (External organisation)
de Haan, W. (Member)
1 Aug 2008 → …Activity: Membership › Membership of network › Academic
Prizes
Press/Media
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Philip Scheltens and Willem de Haan on Plaques, Tangles Throw Off the Brain’s Rhythms
13/03/2020
1 Media contribution
Press/Media: exportcomment