Projects per year
Personal profile
Research interests
The aim of my research is to better understand the relation between brain network activity and cognitive impairment. Having been among the first to describe specific patterns of brain network damage in Alzheimer's disease (AD), during the past years I have developed a computational brain network model of AD. This approach helps to understand both the neurophysiological mechanism of the disease, and a recent insight is that it can also guide treatment selection by solving how to modulate abnormal brain activity in order to optimize network function. Modeling predictions will be tested in Alzheimer patients in the upcoming years using non-invasive brain stimulation.
Specialisation
Alzheimer's disease
Neurophysiology
EEG/MEG
Brain dynamics modeling
Grapht theory
Non-invasive brain stimulation
Related documents
Education/Academic qualification
PhD, In a network state of mind, VU University: -
Award Date: 7 Nov 2012
External positions
Senior Researcher, Amsterdam Neuroscience, Amsterdam, Netherlands
Keywords
- R Medicine (General)
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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de TMSLA studie: Hersenstimulatie om de ziekte van Alzheimer af te remmen : de TMSLA studie
Pijnenburg, Y. (Principal investigator) & de Haan, W. (Project Leader)
01/04/2024 → 31/03/2028
Project: Research
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PP 32745 de TMSLA studie: PP 32745 Hersenstimulatie om de ziekte van Alzheimer af te remmen : de TMSLA studie
Pijnenburg, Y. (Principal investigator) & de Haan, W. (Project Leader)
Hersenstichting Nederland, Alzheimer Nederland
01/04/2024 → 31/03/2028
Project: Research
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PP 32804 Hersenactiviteit: Hersenactiviteit als sleutel Onderzoek naar hersenactiviteit als sleutel voor diagnostiek én behandeling
Pijnenburg, Y. (Principal investigator) & de Haan, W. (Project Leader)
Stichting Steun Alzheimercentrum Amsterdam
01/11/2023 → 31/12/2025
Project: Research
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Hersenactiviteit als sleutel: Onderzoek naar hersenactiviteit als sleutel voor diagnostiek én behandeling
Pijnenburg, Y. (Principal investigator) & de Haan, W. (Project Leader)
Stichting Steun Alzheimercentrum Amsterdam
01/11/2023 → 31/12/2025
Project: Research
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PP 32706 a tACS-MEG study: PP 32706 Improving memory function in early Alzheimer's disease a tACS-MEG study - WE.03-2022-08
Pijnenburg, Y. (Principal investigator) & de Haan, W. (Project Leader)
01/06/2023 → 30/11/2025
Project: Research
Research output
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Network Hyperexcitability in Early-Stage Alzheimer's Disease: Evaluation of Functional Connectivity Biomarkers in a Computational Disease Model
Stam, C. J. & de Haan, W., 2024, In: Journal of Alzheimer s disease. 99, 4, p. 1333-1348 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing
van Nifterick, A. M., Gouw, A. A., van Kesteren, R. E., Scheltens, P., Stam, C. J. & de Haan, W., 1 Dec 2022, In: Alzheimer's Research and Therapy. 14, 1, 101.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Virtual neural network-guided optimization of non-invasive brain stimulation in Alzheimer's disease
Luppi, J. J., Stam, C. J., Scheltens, P. & de Haan, W., 1 Jan 2024, In: PLoS computational biology. 20, 1, e1011164.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Amyloid-β deposition predicts oscillatory slowing of magnetoencephalography signals and a reduction of functional connectivity over time in cognitively unimpaired adults
Scheijbeler, E. P., de Haan, W., Coomans, E. M., den Braber, A., Tomassen, J., ten Kate, M., Konijnenberg, E., Collij, L. E., van de Giessen, E., Barkhof, F., Visser, P. J., Stam, C. J. & Gouw, A. A., 2025, In: Brain Communications. 7, 1, fcaf018.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer's disease drug candidate CT1812
di Caro, V., Cho, E., North, H. A., Caldwell, J., Pandey, K., Duong, D., Grundman, M., de Haan, W., Vijverberg, E. G., Teunissen, C. E., Caggiano, A. O., Seyfried, N. T. & Hamby, M. E., 1 Apr 2025, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 11, 2, e70119.Research output: Contribution to journal › Article › Academic › peer-review
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Translational Computational Modelling Relates AD Pathophysiology to Large-Scale Brain Dynamics
de Haan, W. (Invited speaker)
6 Sept 2022Activity: Talk or presentation › Invited talk › Academic
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NGN webinar - Geheugenpoli in tijden van Corona
Bakker, E. (Speaker) & de Haan, W. (Speaker)
4 Mar 2021Activity: Talk or presentation › Oral presentation › Academic
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Newcastle University, Newcastle upon Tyne, United Kingdom (External organisation)
de Haan, W. (Chair)
Nov 2020 → …Activity: Membership › Membership of committee › Academic
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Dutch Chapter of the Network Science Society (External organisation)
de Haan, W. (Chair)
2018 → 2021Activity: Membership › Membership of network › Professional
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Alzheimer Center (External organisation)
de Haan, W. (Member)
1 Aug 2008 → …Activity: Membership › Membership of network › Academic
Prizes
Press/Media
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Philip Scheltens and Willem de Haan on Plaques, Tangles Throw Off the Brain’s Rhythms
13/03/2020
1 Media contribution
Press/Media: exportcomment