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Brain white matter integrity is crucial for motor coordination and cognitive functioning, and its disruption is strongly implicated in neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders. We need better understanding of how cellular interactions in white matter regions contribute to brain network dysfunctions. My lab advanced induced pluripotent stem cell (iPSC) tools to develop human iPSC-based model system for several neurological disorders to address basic and translational research questions in collaboration with on- and off-site partners. Our goal is to identify and describe glial defects in neurodevelopmental disorders, and to perform proof-of-concept studies for glial-targeted therapy strategies using advanced stem cell technologies.