Personal profile
Research interests
The focus of my research lies on the Second European Carotid Surgery Trial (ECST-2). The ECST-2 is a study in which we randomize between using only optimized medical treatment (OMT) or OMT combined with carotid revascularization (CEA) in patients who suffered stroke due to a plaque in the internal carotid artery. My field of interest will be the clinical outcome in Dutch patients, but with a focus on the cost-effectiveness of the CEA.
Furthermore I am interested in the role of inflammation in carotid plaques and in new MRI techniques that might be better in predicting future stroke in patients with an internal carotid artery plaque.
Specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial
Donners, S. J. A., van Velzen, T. J., Cheng, S. F., Gregson, J., Hazewinkel, A.-D., Pizzini, F. B., Emmer, B. J., Simister, R., Richards, T., Lyrer, P. A., Maurer, M., Smith, G., Tervit, G., van der Steen, L., Pickett, G. E., Gubitz, G., Roozenbeek, B., Scheele, M., Bamford, J. M. & Kooi, M. E. & 5 others, , 1 May 2025, In: Lancet Neurol.. 24, 5, p. 389-399 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile50 Downloads (Pure) -
Carotid stenosis: Novel insights in treatment, pathophysiology and costs
van Velzen, T. J., 2024, 195 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
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Application of mask images of contrast-enhanced MR angiography to detect carotid intraplaque hemorrhage in patients with moderate to severe symptomatic and asymptomatic carotid stenosis
Kassem, M., de Kam, S. S., van Velzen, T. J., van der Geest, R., Wagner, B., Sokolska, M., Pizzini, F. B., Nederkoorn, P. J., Rolf Jäger, H., Brown, M. M., van Oostenbrugge, R. J., Bonati, L. H. & Eline Kooi, M., 1 Nov 2023, In: European journal of radiology. 168, 111145.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study
de Vries, J. J., Autar, A. S. A., van Dam-Nolen, D. H. K., Donkel, S. J., Kassem, M., van der Kolk, A. G., van Velzen, T. J., Kooi, M. E., Hendrikse, J., Nederkoorn, P. J., Bos, D., van der Lugt, A., de Maat, M. P. M. & van Beusekom, H. M. M., 1 Jun 2022, In: PLoS ONE. 17, 6 June, e0269805.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Leukocyte Count Predicts Carotid Artery Stenosis in Men with Ischemic Stroke: Sub Study of the Preventive Antibiotics in Stroke Study (PASS)
van Velzen, T. J., Stolp, J., Westendorp, W. F., Roos, Y. B. W. E. M., van de Beek, D. & Nederkoorn, P. J., 8 Dec 2022, In: Journal of clinical medicine. 11, 24, 7286.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure)