Personal profile
Research interests
Tanja de Gruijl heads the Immunotherapy and Immune monitoring Lab of the Department of Medical Oncology at the Cancer Center of the Amsterdam university medical centers, where she has been appointed Professor of Translational Tumour Immunology and holds a Fenna Diemer Lindeboom Chair. She has over 25 years of experience in the field of tumour immunology and over 250 publications to her name. Her research ranges from preclinical topics to immune monitoring of Phase I-III clinical trials and includes topics like the immune potentiation of tumour-draining lymph nodes and the tumour microenvironment, immunological arming of oncolytic adenoviruses, and nanobody-mediated targeting of (NK)T-cell subsets. Her research has been supported by fellowships and grants from the EU-Horizon2020 program, the Netherlands Organization for Scientific Research (NWO), and the Royal Dutch Cancer Society (KWF) and she is a recipient of a competitive research award of the Prostate Cancer Foundation. She has supervised the initial research that has led to the vaccination platform of DCPrime BV (now Immunicum) and is co-founder of LAVA Therapeutics. She serves as associate editor for Cancer Immunology Research, the Journal for ImmunoTherapy of Cancer, and Clinical and Experimental Immunology. She has been and is a member of the grant review committees of the Royal Dutch Cancer Society (KWF) and the Melanoma Research Alliance, has chaired the Dutch Tumour Immunology Working Party, and is an elected member of the board of directors of the Society for the Immunotherapy of Cancer (SITC).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation
Clayton, G., Toffoli, E. C., de Gruijl, T. D. & van Kooyk, Y., 18 Nov 2025, In: Cell Rep. Med.. 6, 11, p. 102412 1 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile33 Downloads (Pure) -
Exploring the effects of exercise on immune cell function and tumour infiltration in patients with breast cancer receiving neoadjuvant chemotherapy – a feasibility trial
Ubink, A., ten Tusscher, M. R., van der Vliet, H. J., Douma, J. A. J., de Gruijl, T. D., Bontkes, H., Bonnet, P., van Ens, D., Hobo, W., Dolstra, H., Barbé, E., van der Velde, S., Menke-van der Houven van Oordt, C. W., Havenith, S. H. C., Conijn-Mensink, A., van Zweeden, A. A., Westdorp, H., Jacobs, J. F. M. & Buffart, L. M., 1 Jul 2025, In: Brain, Behavior, and Immunity - Health. 46, 101021.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile21 Downloads (Pure) -
Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC
Dudziak, D., Heger, L., Agace, W. W., Bakker, J., de Gruijl, T. D., Dress, R. J., Dutertre, C.-A., Fenton, T. M., Fransen, M. F., Ginhoux, F., Heyman, O., Horev, Y., Hornsteiner, F., Kandiah, V., Kles, P., Lubin, R., Mizraji, G., Prokopi, A., Saar, O. & Sopper, S. & 10 others, , Jan 2025, In: European journal of immunology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile67 Downloads (Pure) -
Immune-modulating effects on tumor-draining lymph nodes of neoadjuvant chemoradiotherapy combined with dual immunotherapy in patients with T3-4N0-2 NSCLC
Ulas, E. B., Koomen, S. J. I., Vrijmoet, A., Houda, I., Korkmaz, H. I., Dickhoff, C., Bahce, I., Senan, S., de Gruijl, T. D., Fransen, M. F., Radonic, T., van Maldegem, F. & Schneiders, F. L., 28 Nov 2025, In: Journal for immunotherapy of cancer. 13, 11, e013237.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis
Ezdoglian, A., Tsang-A-Sjoe, M., Khodadust, F., Burchell, G., Jansen, G., de Gruijl, T., Labots, M. & van der Laken, C. J., 1 Mar 2025, In: Cancer metastasis reviews. 44, 1, 35.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile26 Downloads (Pure)
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Journal for Immunotherapy of Cancer (Journal)
de Gruijl, T. (Reviewer)
1 Jan 2020Activity: Publication peer-review and editorial work › editorial_work
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Cancers (Basel) (Journal)
de Gruijl, T. (Reviewer)
1 Jan 2020Activity: Publication peer-review and editorial work › editorial_work
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Society for Immunotherapy of Cancer (External organisation)
de Gruijl, T. (Member)
2019Activity: Membership › Membership of board › Academic