Dementia,Polygenic Risk Scores,Genetic epidemiology,Clinical genetics,Genome-wide assiciation studies (GWAS)

As a researcher at Amsterdam UMC, my work focuses on understanding the molecular and cellular mechanisms underlying neurodegenerative diseases. Specifically, I am investigating the role of genetic and environmental factors in the onset and progression of Alzheimer's disease and other related dementias in families. More recently, I have focused on translating our current knowledge to clinically relevant outcomes for patients. This includes participating and leading genome-wide association studies, facilitating the use of genetic data by other researchers, create and implement novel criteria for genetic testing in dementia and starting a National Biobank to facilitate translational studies and clinical trials. This aligns precisely with the ‘Vision and Mission’ of Amsterdam Neuroscience, the mission of the human genetics department and the mission of the Amsterdam Alzheimer center. All of which I work closely with.