Research output per year
Research output per year
Personal profile
Research interests
My research focuses on the identification of signaling pathways induced by C-type lectins on dendritic cells and how these signaling pathways lead to pathogen-specific T cell polarization, neutrophil activation as well as anti-viral responses, which could be targeted therapeutically to either enhance immunity or deter aberrant immunity.
Specialisation
Molecular biology, signal transduction, innate immunology
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Collaborations and top research areas from the last five years
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Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome
Gringhuis, S. I., Kaptein, T. M., Wevers, B. A., Theelen, B., van der Vlist, M., Boekhout, T. & Geijtenbeek, T. B. H., 2012, In: Nature immunology. 13, 3, p. 246-U63Research output: Contribution to journal › Article › Academic › peer-review
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C-type lectin receptors in the control of T helper cell differentiation
Geijtenbeek, T. B. H. & Gringhuis, S. I., 2016, In: Nature reviews. Immunology. 16, 7, p. 433-448Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile124 Downloads (Pure) -
Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity
Wevers, B. A., Kaptein, T. M., Zijlstra-Willems, E. M., Theelen, B., Boekhout, T., Geijtenbeek, T. B. H. & Gringhuis, S. I., 2014, In: Cell host & microbe. 15, 4, p. 494-505Research output: Contribution to journal › Article › Academic › peer-review
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Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases
Mesman, A. W., Zijlstra-Willems, E. M., Kaptein, T. M., de Swart, R. L., Davis, M. E., Ludlow, M., Duprex, W. P., Gack, M. U., Gringhuis, S. I. & Geijtenbeek, T. B. H., 2014, In: Cell host & microbe. 16, 1, p. 31-42Research output: Contribution to journal › Article › Academic › peer-review
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HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3
Gringhuis, S. I., Hertoghs, N., Kaptein, T. M., Zijlstra-Willems, E. M., Sarrami-Fooroshani, R., Sprokholt, J. K., van Teijlingen, N. H., Kootstra, N. A., Booiman, T., van Dort, K. A., Ribeiro, C. M. S., Drewniak, A. & Geijtenbeek, T. B. H., 2017, In: Nature immunology. 18, 2, p. 225-235Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure)