Projects per year
Personal profile
Research interests
My lab studies human genome aiming to dissect molecular mechanisms of susceptibility to infections and translate these findings into novel therapies. We have two programmes that focus on (1) primary immunodeficiencies and (2) mechanisms of host-pathogen interaction in tuberculosis.
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Collaborations and top research areas from the last five years
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PP 31471 PIPgen: PP 31471 PI3K/PTEN-related monogenic disease to understand cancer
Nezhentsev, S. (Principal investigator)
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS (IJC)
01/07/2021 → 30/09/2025
Project: Research
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PP 31436 Host - TB: PP 31436 Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis
Nezhentsev, S. (Principal investigator)
01/06/2019 → 31/08/2025
Project: Research
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PI3Kd-SLE: Activated Phosphoinositide 3-kinase delta in patients with Systemic Lupus Erythematosus
Nezhentsev, S. (Principal investigator)
24/01/2022 → 31/01/2024
Project: Research
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Co-fund S. Nezhentsev ARCAID: Amsterdam Rheumatology Center for AutoImmune Diseases
Nezhentsev, S. (Principal investigator)
01/01/2020 → 31/12/2024
Project: Research
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Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Cuchet-Lourenço, D., Eletto, D., Wu, C., Plagnol, V., Papapietro, O., Curtis, J., Ceron-Gutierrez, L., Bacon, C. M., Hackett, S., Alsaleem, B., Maes, M., Gaspar, M., Alisaac, A., Goss, E., AlIdrissi, E., Siegmund, D., Wajant, H., Kumararatne, D., AlZahrani, M. S. & Arkwright, P. D. & 3 others, , 24 Aug 2018, In: Science. 361, 6404, p. 810-813 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access196 Citations (Scopus) -
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T., Curtis, J., Wu, C., Blake-Palmer, K., Perisic, O., Smyth, D., Maes, M., Fiddler, C., Juss, J., Cilliers, D., Markelj, G., Chandra, A. & Farmer, G. & 24 others, , 15 Nov 2013, In: Science. 342, 6160, p. 866-71 6 p.Research output: Contribution to journal › Article › Academic › peer-review
526 Citations (Scopus) -
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu, C., Lo, K., Maes, M., Alisaac, A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y., Nikolayevskyy, V., Baessmann, I., Thye, T., Meyer, C. G., Nürnberg, P., Horstmann, R. D. & Drobniewski, F. & 3 others, , May 2015, In: Nature genetics. 47, 5, p. 523-527 5 p.Research output: Contribution to journal › Article › Academic › peer-review
137 Citations (Scopus) -
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection
Eletto, D., Burns, S. O., Angulo, I., Plagnol, V., Gilmour, K. C., Henriquez, F., Curtis, J., Gaspar, M., Nowak, K., Daza-Cajigal, V., Kumararatne, D., Doffinger, R., Thrasher, A. J. & Nejentsev, S., 23 Dec 2016, In: Nature communications. 7, p. 13992Research output: Contribution to journal › Article › Academic › peer-review
106 Citations (Scopus) -
Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ
Burns, S. O., Plagnol, V., Gutierrez, B. M., Al Zahrani, D., Curtis, J., Gaspar, M., Hassan, A., Jones, A. M., Malone, M., Rampling, D., McLatchie, A., Doffinger, R., Gilmour, K. C., Henriquez, F., Thrasher, A. J., Gaspar, H. B. & Nejentsev, S., Jul 2014, In: Journal of allergy and clinical immunology. 134, 1, p. 215-8 4 p.Research output: Contribution to journal › Article › Academic › peer-review
39 Citations (Scopus)
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Biomarkers of chronically hyperactivated PI3Kδ in patients with APDS
Nezhentsev, S. (Speaker)
16 Sept 2021Activity: Talk or presentation › Oral presentation › Academic
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Studying the Role of Activated Phosphoinositide-3 Kinase Delta in Systemic Lupus Erythematosus
Nezhentsev, S. (Examiner)
20 Jul 2021Activity: Examination › Educational
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Activated PI3 kinase Delta Syndrome (APDS): from genetics to therapy and beyond...
Nezhentsev, S. (Speaker)
15 Jul 2021Activity: Talk or presentation › Invited talk › Academic
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Topoisomerase 2β and its role in the immune system
Nezhentsev, S. (Examiner)
14 Feb 2021Activity: Examination › Educational
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The mycosins of pathogenic mycobacteria: digesting the role of conserved proteases in type VII secretion
Nezhentsev, S. (Examiner)
29 Jan 2021Activity: Examination › Educational
Press/Media
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Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
21/07/2018
1 item of Media coverage
Press/Media: research