Sean Jurgens

Sean Jurgens

DR.

 https://orcid.org/0000-0002-1605-9782
20192025

Research activity per year

Personal profile

Research interests

My research focuses on leveraging large-scale genetic and multi-omic data to understand cardiovascular diseases. Engrained within the Experimental Cardiology Department and the extended group of prof. Connie Bezzina, I study the genetic mechanisms of cardiomyopathies, atrial fibrillation, and various other cardiovascular disorders.

Our group creates and applies advanced statistical approaches to i) perform genetic association analyses to discover risk variants and genes, ii) to create multi-omic risk prediction models, and iii) to dissect the biological mechanisms underlying cardiovascular disorders. 

External positions

Visiting Scientist, Broad Institute of MIT and Harvard

25 Oct 2024 → …

PhD Candidate, Broad Institute of MIT and Harvard

11 Jul 2022 → 24 Oct 2024

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Collaborations and top research areas from the last five years

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  • Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation

    Wijdeveld, L. F. J. M., Ajufo, E., Challa, S. P., Rämö, J. T., Wang, X., Kany, S., Halford, J. L., Weng, L.-C., Choi, S. H., Aragam, K. G., van Tintelen, J. P., Brundel, B. J. J. M., Jurgens, S. J. & Ellinor, P. T., 2025, (E-pub ahead of print) In: JAMA cardiology.

    Research output: Contribution to journal › Article › Academic › peer-review

    1 Citation (Scopus)

  • Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings

    Zheng, S. L., Jurgens, S. J., McGurk, K. A., Xu, X., Grace, C., Theotokis, P. I., Buchan, R. J., Francis, C., de Marvao, A., Curran, L., Bai, W., Pua, C. J., Tang, H. C., Jorda, P., van Slegtenhorst, M. A., Verhagen, J. M. A., Harper, A. R., Ormondroyd, E., Chin, C. W. L. & Ware, J. S. & 20 others, de Marvao, A., Pantazis, A., Baksi, J., Halliday, B. P., Matthews, P., Pinto, Y. M., Walsh, R., Amin, A. S., Wilde, A. A. M., Cook, S. A., Prasad, S. K., Barton, P. J. R., O’Regan, D. P., Lumbers, R. T., Goel, A., Tadros, R., Michels, M., Watkins, H., Bezzina, C. R. & HCM GWAS Collaborators, Mar 2025, In: Nat. Genet.. 57, 3, p. 563-571 9 p., 3328.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    3 Citations (Scopus)

  • Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

    Roselli, C., Surakka, I., Olesen, M. S., Sveinbjornsson, G., Marston, N. A., Choi, S. H., Holm, H., Chaffin, M., Gudbjartsson, D., Hill, M. C., Aegisdottir, H., Albert, C. M., Alonso, A., Anderson, C. D., Arking, D. E., Arnar, D. O., Barnard, J., Benjamin, E. J., Braunwald, E. & Brumpton, B. & 133 others, Campbell, A., Chami, N., Chasman, D. I., Cho, K., Choi, E.-K., Christophersen, I. E., Chung, M. K., Conen, D., Crijns, H. J., Cutler, M. J., Czuba, T., Damrauer, S. M., Dichgans, M., Dörr, M., Dudink, E., Duong, T., Erikstrup, C., Esko, T. N., Fatkin, D., Faul, J. D., Ferreira, M., Freitag, D. F., Ganesh, S. K., Gaziano, J. M., Geelhoed, B., Ghouse, J., Gieger, C., Giulianini, F., Graham, S. E., Gudnason, V., Guo, X., Haggerty, C., Hayward, C., Heckbert, S. R., Hveem, K., Ito, K., Johnson, R., Jukema, J. W., Jurgens, S. J., Kääb, S., Kane, J. P., Kany, S., Kardia, S. L. R., Kavousi, M., Khurshid, S., Kamanu, F. K., Kirchhof, P., Kleber, M. E., Knight, S., Komuro, I., Krieger, J. E., Launer, L. J., Li, D., Lin, H., Lin, H. J., Loos, R. J. F., Lotta, L., Lubitz, S. A., Lunetta, K. L., Macfarlane, P. W., Magnusson, P. K. E., Malik, R., Mantineo, H., Marcus, G. M., März, W., McManus, D. D., Melander, O., Melloni, G. E. M., Meyre, P. B., Miyazawa, K., Mohanty, S., Monfort, L. M., Müller-Nurasyid, M., Nafissi, N. A., Natale, A., Nazarian, S., Ostrowski, S. R., Pak, H.-N., Pang, S., Pedersen, O. B., Pedersen, N. L., Pereira, A. C., Pirruccello, J. P., Preuss, M., Psaty, B. M., Pullinger, C. R., Rader, D. J., Rämö, J. T., Ridker, P. M., Rienstra, M., Risch, L., Roden, D. M., Rotter, J. I., Sabatine, M. S., Schunkert, H., Shah, S. H., Shim, J., Shoemaker, M. B., Simonson, B., Sinner, M. F., Smit, R. A. J., Smith, J. A., Smith, N. L., Smith, J. G., Soliman, E. Z., Sørensen, E., Sotoodehnia, N., Strbian, D., Stricker, B. H., Teder-Laving, M., Sun, Y. V., Thériault, S. B., Thorolfsdottir, R. B., Thorsteinsdottir, U., Tveit, A., van der Harst, P., van Meurs, J., Wang, B., Weiss, S., Wells, Q. S., Weng, L.-C., Wilson, P. W., Xiao, L., Yang, P.-S., Yao, J., Yoneda, Z. T., Zeller, T., Zeng, L., Zhao, W., Zhou, X., The BioBank Japan Project, Regeneron Genetics Center & DBDS Genomic Consortium, 1 Mar 2025, In: Nat. Genet.. 57, 3, p. 539-547 9 p., 11303.

    Research output: Contribution to journal › Article › Academic › peer-review

    3 Citations (Scopus)

  • Polygenic Risk Scores in Dilated Cardiomyopathy: Towards the Future

    Kramarenko, D. R., Jurgens, S. J., Pinto, Y. M., Bezzina, C. R. & Amin, A. S., 1 Dec 2025, In: Current cardiology reports. 27, 1, 87.

    Research output: Contribution to journal › Review article › Academic › peer-review

  • Predicting Atrial Fibrillation After Stroke by Combining Polygenic Risk Scores and Clinical Features

    Tack, R. W. P., Tan, B. Y. Q., Senff, J. R., Prapiadou, S., Kimball, T. N., Khurshid, S., Ashburner, J. M., Jurgens, S. J., Singh, S. D., Weng, L.-C., Gunn, S., Roselli, C., Lunetta, K. L., Benjamin, E. J., Ellinor, P. T., Rosand, J., Mayerhofer, E., Lubitz, S. A. & Anderson, C. D., 1 Apr 2025, In: Stroke. 56, 4, p. 878-886 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

View all 43 research outputs