Projects per year
Personal profile
Research interests
My clinical and research interests lie within diabetes around large hormonal transitions (pregnancy, menopause) and diabetes technology as well as in-hospital glucose regulation.
My goal is to improve the health of women with diabetes during pregnancy and menopause through top clinical care, conducting clinical research with a focus on technology and training the empathic physician of the future.
Currently, I set up a nationwide registry for pregnant women with pregestational diabetes and map the current care paths for these women in the Netherlands (funded by Diabetesfonds). The goal is to be able to benchmark care and implement a national best care protocol.
Also I am workpackage leader of the diabetes research line within the MenoPause consortium (funded by NWO) looking at the effect of (peri)menopause on diabetes development and regulation within the HELIUS cohort as well as the type 1 and type 2 population through interventional studies.
Further, to improve in-hospital care we perform the GUIDE study (funded by ZonMw) comparing a basal-bolus to a sliding-scale insuline regimen in postoperative surgical patients with type 2 diabetes in the hospital and look at the effect on postoperative wound infections.
Specialisation
diabetes
External positions
member of the board, Diabeteskamer
1 Dec 2024 → …
member (NIV), Platform Diabeteshulpmiddelen (NDF)
1 Jan 2020 → …
sounding board group for the update of diabetes guidelines, Dutch Association of Internal Medicine (NIV)
1 Jan 2019 → …
member, Programme Organising Committee of the Dutch Endocrine Meeting
1 Jan 2018 → 1 Mar 2025
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Collaborations and top research areas from the last five years
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Projects
- 5 Active
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DiaPregNL: Close the gap for women with diabetes: monitoring perinatal outcomes of pregnant women with pre-pregnancy diabetes and their children in the Netherlands
Bisschop, P. (Principal investigator) & Siegelaar, S. (Project Leader)
01/07/2024 → 30/06/2028
Project: Research
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MenoPause WP 2.1 klinisch: MenoPause: More healthy and productive years for Peri-menopausal women
Bisschop, P. (Principal investigator) & Siegelaar, S. (Project Leader)
01/02/2024 → 31/01/2032
Project: Research
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The Guide trial: Improvement of postoperative glucose control to lower surgical site infections 30 days after surgery in patients with diabetes mellitus type 2: a basal-bolus insulin regimen versus a sliding-scale ...
Bisschop, P. (Principal investigator) & Siegelaar, S. (Project Leader)
01/01/2024 → 31/12/2027
Project: Research
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DARE: Dual Hormone fully closed loop in type 1 diabetes mellitus: a randomized trial
Bisschop, P. (Principal investigator) & Siegelaar, S. (Project Leader)
02/11/2023 → 31/10/2025
Project: Research
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Cagrilintide/Semaglutide: Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity U1111-1261-1912
Bisschop, P. (Principal investigator) & Siegelaar, S. (Project Leader)
04/08/2022 → 19/01/2027
Project: Research
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Cost-effectiveness of advanced hybrid closed loop therapy compared to standard insulin therapy for type 1 diabetes in pregnancy: an economic evaluation of the CRISTAL trial
Azahaf, S., Beunen, K., Van Wilder, N., Ballaux, D., Vanhaverbeke, G., Taes, Y., Aers, X. P., Nobels, F., Van Huffel, L., Marlier, J., Lee, D., Cuypers, J., Preumont, V., Siegelaar, S. E., Painter, R. C., Laenen, A., Gillard, P., Mathieu, C., Luyten, J. & Benhalima, K., Mar 2025, In: EClinicalMedicine. 81, 103106.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial
Rademaker, D., de Wit, L., Duijnhoven, R. G., Voormolen, D. N., Mol, B. W., Franx, A., Devries, J. H., Painter, R. C., van Rijn, B. B., Siegelaar, S. E., Akerboom, B. M. C., Kiewiet-Kemper, R. M., Verwij-Didden, M. A. L., Assouiki, F., Kuppens, S. M., Oosterwerff, M. M., Stekkinger, E., Diekman, M. J. M., Vogelvang, T. E. & Belle-van Meerkerk, G. & 43 others, , 11 Feb 2025, In: JAMA. 333, 6, p. 470-478 9 p.Research output: Contribution to journal › Article › Academic › peer-review
4 Citations (Scopus) -
Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome
Kleinendorst, L., Siegelaar, S. E., Roessler, H. I., Meiwand, L., van den Boogaard, M., de Bruin-Bon, R. H. A. C. M., van Duinen, K. F., Planken, R. N., Jaspars, E. H., Kemperman, P. M. J. H., Bouma, B. J., Nichols, C. G., Bekkenk, M. W., van Haaften, G. W. & van Haelst, M. M., 1 Dec 2025, In: Scientific reports. 15, 1, 17704.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Advanced Hybrid Closed-Loop Therapy Compared With Standard Insulin Therapy Intrapartum and Early Postpartum in Women With Type 1 Diabetes: A Secondary Observational Analysis From the CRISTAL Randomized Controlled Trial
Beunen, K., Gillard, P., van Wilder, N., Ballaux, D., Vanhaverbeke, G., Taes, Y., Aers, X.-P., Nobels, F., van Huffel, L., Marlier, J., Lee, D., Cuypers, J., Preumont, V., Siegelaar, S. E., Painter, R. C., Laenen, A., Mathieu, C. & Benhalima, K., 1 Nov 2024, In: Diabetes care. 47, 11, p. 2002-2011 10 p.Research output: Contribution to journal › Article › Academic › peer-review
6 Citations (Scopus) -
Basal cortisol in relation to metyrapone confirmation in predicting adrenal insufficiency after pituitary surgery
Huisman, P. E., Siegelaar, S. E., Hoogmoed, J., Post, R., Peters, S., Houben, M., Hillebrand, J. J., Bisschop, P. H., Pereira, A. M. & Bruinstroop, E., Apr 2024, In: Pituitary. 27, 2, p. 151-159 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access