Personal profile
Research interests
My research concerns lymphoproliferative malignancies, especially indolent lymphoma (including CLL) and Hodgkin's lymphoma. I am head of the national indolent lymphoma working group (HOVON) and act as a principal investigator for international trials and projects in indolent lymphoma and Hodgkin's lymphoma. In addition, I participate in clinical trials of the HOVON Lunenburg phase I / II consortium, the European Hematology assoociation EHA lymphoma group; and I am a member of the executive committee of the EORTC lymphoma group. Related to these projects I perform translational research into the interactions of lymphoma cells with the immune system; the research focuses mainly on how the immune system can best be used in the treatment of these diseases and the identification of biomarkers for response to immunotherapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Functional Differences between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL
Hofland, T., de Weerdt, I., Endstra, S., Jongejan, A., Platenkamp, L., Remmerswaal, E. B. M., Moerland, P. D., ten Berge, I. J. M., Levin, M.-D., Kater, A. P. & Tonino, S. H., 2020, In: HemaSphere. 4, 2Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
Human CXCR5+PD-1+ CD8 T cells in healthy individuals and patients with hematologic malignancies
Hofland, T., Martens, A. W. J., van Bruggen, J. A. C., de Boer, R., Schetters, S., Remmerswaal, E. B. M., Bemelman, F. J., Levin, M.-D., Bins, A. D., Eldering, E., Kater, A. P. & Tonino, S. H., Mar 2021, In: European journal of immunology. 51, 3, p. 703-713 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented in Vitro by Adequate Activating Signaling
Hofland, T., Endstra, S., Gomes, C. K. P., de Boer, R., de Weerdt, I., Bobkov, V., Riedl, J. A., Heukers, R., Smit, M. J., Eldering, E., Levin, M.-D., Kater, A. P. & Tonino, S. H., 1 Dec 2019, In: HemaSphere. 3, 6, e308.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
de Weerdt, I., Hofland, T., de Boer, R., Dobber, J. A., Dubois, J., van Nieuwenhuize, D., Mobasher, M., de Boer, F., Hoogendoorn, M., Velders, G. A., van der Klift, M., Remmerswaal, E. B. M., Bemelman, F. J., Niemann, C. U., Kersting, S., Levin, M.-D., Eldering, E., Tonino, S. H. & Kater, A. P., 10 Sept 2019, In: Blood advances. 3, 17, p. 2642-2652 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Downloads (Pure) -
Reinvigorating T and NK cells in chronic lymphocytic leukemia
Hofland, T., 2020, 208 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal