Personal profile
Research interests
Immunology, glycosylation, dendritic cells, glycan-binding receptors, anti-tumor immunity
Specialisation
Cellular glycosylation is a highly dynamic process that alters upon activation, inflammation, and oncogenic transformation. Although it has been known for decades that cell surface glycans are highly diverse, it is still unclear how glycan heterogeneity is established and how this impacts tumor cell biology and immune cell recognition.
During my cum laude PhD and postdoctoral years I studied the impact of glycosylation and glycan-binding receptors on dendritic cell biology and specialized in the field of glyco-immunology. I obtained a prestigious NWO-VENI grant in 2010 that allowed me to dissect the signaling properties of glycan-binding receptors. With grants from the Dutch Cancer Society, Cancer Center Amsterdam and European Marie Curie ITN network and NWO-ASPASIA, I have established my own independent research group that aims to unravel how tumor glycans affect tumor progression, metastasis and anti-tumor immunity.
Related documents
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Presentation Is Essential for Glycan-Lectin Recognition at the Molecular and Cellular Levels: The Interaction of Tumor-Associated O-Glycans with the Macrophage Galactose-Type Lectin
Grosso, A. S., Diniz, A., Soares, C. O., Goerdeler, F., Gimeno, A., Coelho, P., Coelho, H., Lima, C. D. L., Pinheiro, B., Lete, M. G., Garcia-Martin, F., Jaroentomeechai, T., Gomes, J., Reis, C. A., Westerlind, U., Corzana, F., Palma, A. S., Clausen, H., Jiménez-Barbero, J. & van Vliet, S. J. & 2 others, , 26 Jan 2026, In: JACS Au. 6, 1, p. 82-94 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Downloads (Pure) -
Ligand-specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc-containing glycan structures
van der Meijs, N. L., Hatinguais, R., de Kok, M., Li, R. J. E., Godefa, T. M., Thijssen, V. L. J. L., van Kooyk, Y. & van Vliet, S. J., 2025, (E-pub ahead of print) In: FEBS journal.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Sialic acids in cancer biology and immunity—recent advancements
van Vliet, S. J. & van Kooyk, Y., 1 Oct 2025, In: Journal of biological chemistry. 301, 10, 110641.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
Tumor desialylation surpasses anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer
van der Haar Àvila, I., Zhang, T., Lorrain, V., Keuning, E., Ali, L. A., Chadick, C., García-García, S., Boon, L., de Haan, N., García-Vallejo, J. J., van Kooyk, Y. & van Vliet, S. J., 1 Nov 2025, In: International Journal of Cancer. 157, 9, p. 1948-1962 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Downloads (Pure) -
Integration of Stromal Cells and Hydrogel Below Epithelium Results in Optimal Barrier Properties of Small Intestine Organoid Models
Asal, M., Thon, M., Waaijman, T., Bontkes, H. J., van Vliet, S. J., Mebius, R. E. & Gibbs, S., 1 Dec 2024, In: Biomedicines. 12, 12, 2913.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile68 Downloads (Pure)
Activities
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Nature Communications (Journal)
van Vliet, S. (Reviewer)
2025Activity: Publication peer-review and editorial work › Publication peer-review
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ACS Central Science (Journal)
van Vliet, S. (Reviewer)
2025Activity: Publication peer-review and editorial work › Publication peer-review
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Cell Reports (Journal)
van Vliet, S. (Reviewer)
2025Activity: Publication peer-review and editorial work › Publication peer-review
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RSC Carbohydrate Chemistry – Chemical and Biological Approaches (Journal)
van Vliet, S. (Reviewer)
2025Activity: Publication peer-review and editorial work › Publication peer-review
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Frontiers in Immunology (Journal)
van Vliet, S. (Member of editorial board)
2025Activity: Publication peer-review and editorial work › Editorial activity
Prizes
Press/Media
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Lecture for Frineds & Family day Biomedical Sciences
16/11/2024
1 Media contribution
Press/Media: publicengagement
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Journal club for "Antibuddies - Science communication & immunology"
18/09/2021
1 Media contribution
Press/Media: publicengagement