Research output per year
Research output per year
Personal profile
Research interests
My research focuses on differences of sex development (DSD) and transgender care for adolescents. Within the field of DSD my interest is gonadal function and pathology. Participation in the international DSD registry (I-DSD) allows collection of data from individuals with rare conditions. For example, we are currently finishing an international study on gonadal outcomes in 17beta-HSD and 5alpha-reductase deficiency. In addition, I have an interest in sex steroid treatment. Through national collaboration we are starting a project to compare pubertal induction with transdermal versus oral estradiol in girls with Turner syndrome.
Within the field of transgender care our clinical studies have focused on treatment trajectories, including continuation/discontinuation of endocrine treatment, and on the efficacy and safety of endocrine treatment for adolescents. Reported treatment outcomes include growth/adult height, development of desired sex characteristics (breast development, voice change), safety data such as changes in bone mineral density. Research is performed in close collaboration with endocrinologists, psychologists, psychiatrists, surgeons and ethicists. In 2021 we started an international multicenter prospective study of endocrine treatment in transgender adolescents, ENIGI adolescents, which is ongoing. In addition, we are starting a project evaluating the long-term safety of GnRH analogue treatment in transgender adolescents.
Specialisation
Differences of Sex development (DSD), transgender care, puberty, gonads, sex steroids
Education/Academic qualification
PhD, The role of the androgen receptor in regulation of Wolffian duct development, University of Cambridge
Award Date: 23 Jul 2005
Keywords
- RJ101 Child Health. Child health services
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Collaborations and top research areas from the last five years
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21-deoxycortisol as a second-tier test in congenital adrenal hyperplasia newborn screening in The Netherlands: two-year evaluation
Olthof, A., Bouva, M. J., Claahsen-van der Grinten, H. L., Westra, D., Dekkers, E., Heijboer, A. C., Hannema, S. E. & Boelen, A., 2025, (E-pub ahead of print) In: Archives of disease in childhood.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure) -
Blood pressure and its associations in 554 children and young people with congenital adrenal hyperplasia
Lawrence, N. R., Bacila, I., Tonge, J., Dawson, J., Collins, G. S., Lang, Z.-Q., Bryce, J., Alimussina, M., Chen, M., Ali, S. R., Adam, S., van den Akker, E. L. T., Bachega, T. A. S. S., Baronio, F., Birkebæk, N. H., Bonfig, W., Claahsen van der Grinten, H., Cools, M., Costa, E. C. & Debono, M. & 30 others, , 1 May 2025, In: European Journal of Endocrinology. 192, 5, p. 529-539 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
Consensus-Based Expert Recommendations for Diagnosis and Clinical Management of Vanishing White Matter
van Voorst, R. J., Schoenmakers, D. H., Bonkowsky, J. L., Vanderver, A., Krägeloh-Mann, I., Bernard, G., Bertini, E., Fatemi, A., Sgobbi, P. V., Wolf, N. I., Groeschel, S., Tonduti, D., Sevin, C., Orthmann-Murphy, J. L., Schöls, L., Salsano, E., Brais, B., Jaffe, N., ter Horst, K. W. & Hannema, S. E. & 18 others, , 9 Dec 2025, In: Neurology. 105, 11, p. e214320Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile4 Downloads (Pure) -
Continuity of care in Klinefelter syndrome: age-adapted modules for standardized clinical data collection (I-KS)
Grasemann, C., Gravholt, C. H., Breen, L., Aksglaede, L., Lucas-Herald, A., Alimussina, M., Boettcher, C., Wernsmann, J., Bauer, J. J., Bryce, J., Carlomagno, F., Hannema, S. E., Isidori, A., Mazen, I., Nordenstroem, A. & Ahmed, S. F., 1 Oct 2025, In: Endocr. Connect.. 14, 10, e250196.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
EndoCompass project: research roadmap for reproductive and developmental endocrinology
Cools, M., Krausz, C., Juul, A., Macut, D., Andersen, M. S., Andersson, A. M., Andoniadou, C. L., Ahmed, S. F., Bakker, J., Bashamboo, A., Behre, H. M., Bonomi, M., Busch, A. S., De Roo, C., Dessens, A., Fakhar-I-Adil, M., Fanelli, F., Fisher, A. D., Flück, C. & Gambineri, A. & 32 others, , 1 Oct 2025, In: European Journal of Endocrinology. 193, p. ii97-ii116Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile2 Downloads (Pure)