Personal profile
Research interests
The plasma membrane of hepatocytes harbors several drug extrusion pumps, such as MRP2 (ABCC2), ABCG2 and MDR1 (ABCB1) in the canalicular membrane and MRP3 (ABCC3) and MRP4 (ABCC4) in the basolateral membrane. These ATP-dependent transporters are expressed both in liver and in the intestine; therefore they determine to a large extent the pharmacokinetic behaviour of drugs. In mouse strains with disruptions of the various transporter genes (as well as combined gene disruptions) we determine the role of these transporters in pharmacokinetics of various classes of drugs. These issues will become increasingly important for drug development as well as the elucidation of drug-drug interactions.
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Collaborations and top research areas from the last five years
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The role of bile salts in itch receptor activation
Wolters, F., Tolenaars, D., van Weeghel, M., de Waart, D., van de Graaf, S. F. J., Paulusma, C. C., Verhoeven, A., Beuers, U. & Oude Elferink, R., 1 Nov 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 8, 167972.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1−/− Ldlr−/− mice
Porteiro, B., Roscam Abbing, R. L. P., Panhuis, W. I. H., de Waart, D. R., Duijst, S., Bolt, I., Vogels, E. W., Levels, J. H. M., Bosmans, L. A., Vos, W. G., Oude Elferink, R. P. J., Lutgens, E. & van de Graaf, S. F. J., 1 Aug 2024, In: Journal of lipid research. 65, 8, 100594.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs
Li, W., Sparidans, R. W., Wang, Y., Martins, M. L. F., de Waart, D. R., van Tellingen, O., Song, J.-Y., Lebre, M. C., van Hoppe, S., Wagenaar, E., Beijnen, J. H. & Schinkel, A. H., 1 Jun 2024, In: Biomedicine and Pharmacotherapy. 175, 116644.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs
Li, W., Iusuf, D., Sparidans, R. W., Wagenaar, E., Wang, Y., de Waart, D. R., Martins, M. L. F., van Hoppe, S., Lebre, M. C., van Tellingen, O., Beijnen, J. H. & Schinkel, A. H., 1 Apr 2023, In: Pharmacological research. 190, 106724.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis
van de Wiel, S. M. W., Porteiro, B., Belt, S. C., Vogels, E. W. M., Bolt, I., Vermeulen, J. L. M., de Waart, D. R., Verheij, J., Muncan, V., Oude Elferink, R. P. J. & van de Graaf, S. F. J., 1 May 2022, In: JHEP Reports. 4, 5, p. 100463 100463.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Downloads (Pure)