Personal profile
Research interests
Development of patient specific treatment planning to enhance and optimize clinical effectiveness of HIPEC in colorectal cancer patients.
Specialisation
Radiobiology, Molecular Biology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Roxan Helderman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer
Wouters, V. M., Helderman, R. F. C. P. A., Cameron, K., van der Hooff, S. R., Torang, A., van den Bergh, S., Jackstadt, R., Sansom, O. J., van Neerven, S. M. & Medema, J. P., 7 Jul 2025, In: Oncogene. 44, 25, p. 2091-2102 12 p., 4443.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile32 Downloads (Pure) -
GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells
Zhang, L., Atencia Taboada, L., Baglamis, S., de Kroon, M., Elshout, C., Ramesh, P., Helderman, R. F. C. P. A., Torang, A., Cameron, K., van Driel, M. S., Wouters, V. M., van Neerven, S. M. & Medema, J. P., 1 Dec 2025, In: Oncogenesis. 14, 1, 25.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile36 Downloads (Pure) -
Application of HIPEC simulations for optimizing treatment delivery strategies
Löke, D. R., Kok, H. P., Helderman, R. F. C. P. A., Bokan, B., Franken, N. A. P., Oei, A. L., Tuynman, J. B., Tanis, P. J. & Crezee, J., 2023, In: International journal of hyperthermia. 40, 1, 2218627.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure) -
Elevated temperatures and longer durations improve the efficacy of oxaliplatin- and mitomycin C-based hyperthermic intraperitoneal chemotherapy in a confirmed rat model for peritoneal metastasis of colorectal cancer origin
Helderman, R. F. C. P. A., Bokan, B., van Bochove, G. G. W., Rodermond, H. M., Thijssen, E., Marchal, W., Torang, A., Löke, D. R., Franken, N. A. P., Kok, H. P., Tanis, P. J., Crezee, J. & Oei, A. L., 2023, In: Frontiers in oncology. 13, 1122755.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile40 Downloads (Pure) -
Improving the HIPEC treatment delivery for colorectal cancer patients with peritoneal metastasis: The heat and time is on
Helderman, R. F. C. P. A., 14 Apr 2023, 253 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal