Personal profile
Research interests
- Pigment cell disorders of the skin.
Pigment cell disorders, such as vitiligo, are characterized by changes in skin pigmentation. Vitiligo is a depigmenting skin condition, mediated by autoimmunity against skin melanocytes. The visibility of white skin lesions in vitiligo patients and patients’ uncertainty on the disease course can have a major impact on the quality of life.
We aim to understand the pathogenesis of vitiligo in order to improve treatment options for patients. Moreover, we found that vitiligo patients have less risk of getting melanoma and other skin cancers. Conversely, melanoma patients who develop vitiligo have an improved survival. We are exploring the relationship of vitiligo and melanoma, to develop new types of immunotherapy for melanoma by the induction of vitiligo-associated immunity. In addition, we study vitiligo as a potential biomarker for immunotherapy response of melanoma patients.
We perform a wide range of research methodologies, including experimental and translational research on immunological, biochemical, molecular and cell biological mechanisms, as well as preclinical research in disease models and clinical or epidemiological research in patients.
- Read more (in Dutch) at www.pigmentfonds.nl and (in English) at www.rosalieluiten.nl
Specialisation
immunology, oncology, pigment cell research, dermatology, autoimmunity, cancer immunotherapy, immunomonitoring, vitiligo, skin cancer, melanoma, basal cell carcinoma
Related documents
Education/Academic qualification
PhD, Chimeric antibodies against carcinoma: IgE and bispecific antibodies, Leiden University
1 May 1993 → 1 May 1997
Award Date: 15 Jan 1998
External positions
Associate Editor, Pigment Cell Melanoma Research, Publisher Wiley
1 Mar 2024 → …
Committe member, Stichting Catharina van Tussenbroek
2022 → …
Council Member, European Society for Pigment Cell Research (ESPCR)
… → 2017
Chair, Stichting Pigmentfonds Nederland
Vice Chair, Vereniging voor VernieuwingsImpuls Onderzoekers (VVViO)
… → 2014
Vice Chair Veni Committee, ZonMw
… → 1 Jan 2023
Member Veni Committee, ZonMw
… → 1 Jan 2023
Member Rubicon committee, ZonMw
… → 2014
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis
Teulings, H.-E., Limpens, J., Jansen, S. N., Zwinderman, A. H., Reitsma, J. B., Spuls, P. I. & Luiten, R. M., 2015, In: Journal of clinical oncology. 33, 7, p. 773-781Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile47 Downloads (Pure) -
Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy
van den Boorn, J. G., Picavet, D. I., van Swieten, P. F., van Veen, H. A., Konijnenberg, D., van Veelen, P. A., van Capel, T., Jong, E. C. D., Reits, E. A., Drijfhout, J. W., Bos, J. D., Melief, C. J. M. & Luiten, R. M., 2011, In: Journal of investigative dermatology. 131, 6, p. 1240-1251Research output: Contribution to journal › Article › Academic › peer-review
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Oxidation events and skin aging
Kammeyer, A. & Luiten, R. M., 2015, In: Ageing research reviews. 21, p. 16-29Research output: Contribution to journal › Review article › Academic › peer-review
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Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy
Tjin, E. P. M., Krebbers, G., Meijlink, K. J., van de Kasteele, W., Rosenberg, E. H., Sanders, J., Nederlof, P. M., van de Wiel, B. A., Haanen, J. B. A. G., Melief, C. J. M., Vyth-Dreese, F. A. & Luiten, R. M., 2014, In: Cancer immunology research. 2, 6, p. 538-546Research output: Contribution to journal › Article › Academic › peer-review
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Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial
Teulings, H.-E., Tjin, E. P. M., Willemsen, K. J., van der Kleij, S., Meulen, S. T., Kemp, E. H., Krebbers, G., van Noesel, C. J. M., Franken, C. L. M. C., Drijfhout, J. W., Melief, C. J. M., Nieuweboer-Krobotova, L., Nieweg, O. E., van der Hage, J. A., van der Veen, J. P. W., Relyveld, G. N. & Luiten, R. M., 2018, In: Oncoimmunology. 7, 4, e1419113.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Downloads (Pure)
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Pigment cell & melanoma research (Journal)
Luiten, R. (Member of editorial board)
1 Apr 2024 → 1 Apr 2026Activity: Publication peer-review and editorial work › Publication peer-review
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Nederlandse Vereniging voor Experimentele Dermatologie (Event)
Luiten, R. (Member)
26 Jan 2024 → 26 Jan 2027Activity: Membership › Membership of board › Academic
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Amsterdam Valorisation Board (External organisation)
Luiten, R. (Member)
2022Activity: Membership › Membership of board › Academic
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Stichting Fonds Doctor Catharine van Tussenbroek (External organisation)
Luiten, R. (Member)
1 Mar 2020Activity: Membership › Membership of committee › Academic
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AII - Cancer immunology (Organisational unit)
Luiten, R. (Member)
2017 → 2023Activity: Membership › Membership of board › Academic