Rik Ossenkoppele

2025

Amyloid-β and tau deposition in traumatic brain injury: a study of Vietnam War veterans

de Bruin, H., Groot, C., Kamps, S., Vijverberg, E. G. B., Steward, A., Dehsarvi, A., Pijnenburg, Y. A. L., Ossenkoppele, R. & Franzmeier, N., 10 Jan 2025, In: Brain Communications. 7, 1, fcaf009.

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Assessing social cognition and risk-taking behaviour in patients with young-onset dementia: Study protocol for the YOD-RiSoCo observational prospective cohort study

Gelmers, F., Huitema, R. B., Scheenen, M. E., van Munster, B. C., Spikman, J. M., Koopmans, R., de Heus, R., Salazar, A., Duits, F., Groeneveld, J., van den Berg, L., Vanneste, P., Ossenkoppele, R., van der Lee, S., Pijnenburg, Y., Blom, M., de Vries, H., de Vijlder, L., Muller, L. & Oyebode, J. & 40 others, de Bruin, A., Gooskens, E., Gerritsen, A., van Vliet, C., van de Wouw, H., Hosseinion-Schilder, N., Bakx, P., van den Berg, E., Bodde, H., Seelaar, H., Poos, J., Papma, J., de Boer, L., Jiskoot, L., van Munster, B., Gelmers, F., Spikman, J., van Daele, L., van de Glind, M.-C., van Eersel, M., Scheenen, M., Huitema, R., Appelhof, B., Bakker, C., Vermazeren, J., Donkers, J., Mellendijk, J., Mortier, M., van Westendorp, S., Hibbs, C., David, C., de Vugt, M., Ritzen, M., Bartels, S., Hendriks, S., van der Waal, H.-J., Danen, S., Renders, C., Wallner, C. & YOD-INCLUDED Consortium, 1 May 2025, In: PLoS ONE. 20, 5 May, e0324517.

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Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study

Oomens, J. E., van Gils, V., Vos, S. J. B., Freeze, W. M., Maserejian, N. N., Curiale, G., Gillis, C., Boada, M., van der Flier, W. M., Hort, J., Johnson, S. C., Lleó, A., Ramakers, I. H., Rodrigue, K. M., Sánchez-Juan, P., Sarazin, M., Scarmeas, N., Zetterberg, H., Alcolea, D. & Barkhof, F. & 24 others, Blennow, K., Bottlaender, M., den Braber, A., Cerman, J., Drake-Perez, M., Fortea, J., Handels, R., Ingala, S., Jiménez-Bonilla, J. F., Karavasilis, S., Lagarde, J., Legdeur, N., Lorenzini, L., Marquié, M., Moonen, J. E. F., Olivieri, P., Orellana, A., Ossenkoppele, R., Rivera-Rivera, L. A., Rodríguez-Rodriguez, E., Ruiz Laza, A., European Prevention of Alzheimer’s Dementia (EPAD) Consortium, Fundació ACE Healthy Brain Initiative (FACEHBI) Study Group & BIOFACE Study Group, 22 Jan 2025, In: JAMA network open. 8, 1, p. e2455571 e2455571.

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Characterizing visual read tau-PET-negative participants with Alzheimer's disease dementia

Rikken, R. M., Coomans, E. M., de Koning, L. A., Visser, D., Neutelings, E., den Braber, A., Collij, L. E., Golla, S. S. V., Barkhof, F., Alzheimer's Disease Neuroimaging Initiative & for ADNI, 1 Apr 2025, In: Alzheimer s & dementia. 21, 4, e14423.

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Depressive Symptoms and Amyloid Pathology

Wiels, W. A., Oomens, J. E., Engelborghs, S., Baeken, C., von Arnim, C. A. F., Boada, M., Didic, M., Dubois, B., Fladby, T., van der Flier, W. M., Frisoni, G. B., Fröhlich, L., Gill, K. D., Grimmer, T., Hildebrandt, H., Hort, J., Itoh, Y., Iwatsubo, T., Klimkowicz-Mrowiec, A. & Lee, D. Y. & 95 others, Lleó, A., Martinez-Lage, P., de Mendonça, A., Meyer, P. T., Kapaki, E. N., Parchi, P., Pardini, M., Parnetti, L., Popp, J., Rami, L., Reiman, E. M., Rinne, J. O., Rodrigue, K. M., Sánchez-Juan, P., Santana, I., Sarazin, M., Scarmeas, N., Skoog, I., Snyder, P. J., Sperling, R. A., Villeneuve, S., Wallin, A., Wiltfang, J., Zetterberg, H., Ossenkoppele, R., Verhey, F. R. J., Vos, S. J. B., Visser, P. J., Jansen, W. J., Alcolea, D., Altomare, D., Baiardi, S., Baldeiras, I., Bateman, R. J., Blennow, K., Bottlaender, M., den Braber, A., van Buchem, M. A., Byun, M. S., Cerman, J., Chen, K., Chipi, E., Day, G. S., Drzezga, A., Eckerström, M., Ekblad, L. L., Epelbaum, S., Förster, S., Fortea, J., Freund-Levi, Y., Frings, L., Guedj, E., Hausner, L., Hellwig, S., Huey, E. D., Jiménez-Bonilla, J. F., Johnson, K. A., Juaristi, A. I., Kandimalla, R., Paraskevas, G., Kern, S., Kirsebom, B.-E. S., Kornhuber, J., Lagarde, J., Landau, S. M., Legdeur, N., Llibre Guerra, J. J., Maserejian, N. N., Marquié, M., Minatani, S., Morbelli, S. D., Mroczko, B., Ntanasi, E., de Oliveira, C. R., Olivieri, P., Orellana, A., Perrin, R. J., Peters, O., Prabhakar, S., Ramakers, I. H., Rodríguez-Rodriguez, E., Ruiz, A., Rüther, E., Selnes, P., Silva, D., Soininen, H., Spiru, L., Takeda, A., Teichmann, M., Tijms, B. M., Teunissen, C. E., Thompson, L. I., Vogelgsangs, J., Vöglein, J. & The Amyloid Biomarker Study group; for the Alzheimer's Disease Neuroimaging Initiative (ADNI), the A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Harvard Aging Brain Study (HABS), Japanese ADNI, Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group, 5 Mar 2025, In: JAMA psychiatry. 82, 3, p. 296-310 15 p.

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Enlarged cavum septum pellucidum as a neuroimaging signature of head impact exposure

Kamps, S., Hempel, H. L., van Amerongen, S., de Bruin, H., van der Linden, F. H. C., Venkatraghavan, V., van der Flier, W. M., Pijnenburg, Y. A. L., Barkhof, F., Scheltens, P. & Alzheimer's Disease Neuroimaging Initiative (ADNI), 2025, In: Brain Communications. 7, 2, fcaf085.

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Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease

Pichet Binette, A., Smith, R., Salvadó, G., Tideman, P., Glans, I., van Westen, D., Groot, C., Ossenkoppele, R., Stomrud, E., Parchi, P., Zetterberg, H., Blennow, K., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., Hansson, O., Adegoke, O., Hussen, K. A., Aisen, P. & Ajayi, A. & 15 others, Amaza, H., Apostolova, L. G., Ashford, M., Ayo, O., Barnes, L., Beckett, L., Bernard, M., Bernhardt, H., Boatwright, V., Borowski, B., Brylska, M., Buckholtz, N., Cabrera, Y., Cairns, N. J. & Alzheimers Disease Neuroimaging Initiative, 2025, (E-pub ahead of print) In: JAMA Neurology.

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Frequency and Clinical Outcomes Associated with Tau Positron Emission Tomography Positivity

Moscoso, A., Heeman, F., Raghavan, S., Costoya-Sánchez, A., van Essen, M., Mainta, I., Camacho, V., Rodríguez-Fonseca, O., Silva-Rodríguez, J., Perissinotti, A., Gu, Y., Yun, J., Peretti, D., Ribaldi, F., Coomans, E. M., Brum, W. S., Grothe, M. J., Aguiar, P., Bischof, G. R. N. & Drzezga, A. & 27 others, Seo, S. W., Villeneuve, S., Malpetti, M., O'Brien, J. T., Rowe, J. B., van de Giessen, E. M., Ossenkoppele, R., Jagust, W. J., Smith, R., Hansson, O., Frisoni, G. B., Garibotto, V., Soleimani-Meigooni, D. N., Carrillo, M., Dickerson, B. C., la Joie, R., Rabinovici, G. D., Apostolova, L. G., Lamontagne, P. J., Pontecorvo, M. J., Johnson, K. A., Sperling, R. A., Weiner, M. W., Petersen, R. C., Jack, C. R., Vemuri, P. & Schöll, M., 2025, (E-pub ahead of print) In: JAMA.

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Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data

Karlsson, L., Vogel, J., Arvidsson, I., Åström, K., Strandberg, O., Seidlitz, J., Bethlehem, R. A. I., Stomrud, E., Ossenkoppele, R., Ashton, N. J., Zetterberg, H., Blennow, K., Palmqvist, S., Smith, R., Janelidze, S., la Joie, R., Rabinovici, G. D., Binette, A. P., Mattsson-Carlgren, N. & Hansson, O., 1 Feb 2025, In: Alzheimer s & dementia. 21, 2, p. e14600 e14600.

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No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population

Lamé, A., Thomas, E. G., van de Schraaf, S. A. J., Groot, C., Sudre, C. H., Barkhof, F., Muller, M., Ossenkoppele, R. & Rhodius-Meester, H. F. M., 1 Jan 2025, In: Aging Brain. 7, 100137.

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Plasma and MRI biomarkers capture neuronal damage in former professional boxers

Kamps, S., van Amerongen, S., Blujdea, E. R., Hoppen, M. I., Bongers, B., Schelvis, K. H., Caton, D. K., Königs, M., Teunissen, C. E., Scheltens, P., Ossenkoppele, R. & Vijverberg, E. G. B., 1 Dec 2025, In: Scientific reports. 15, 1, 20005.

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Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease

Horie, K., Salvadó, G., Koppisetti, R. K., Janelidze, S., Barthélemy, N. R., He, Y., Sato, C., Gordon, B. A., Jiang, H., Benzinger, T. L. S., Stomrud, E., Holtzman, D. M., Mattsson-Carlgren, N., Morris, J. C., Palmqvist, S., Ossenkoppele, R., Schindler, S. E., Hansson, O. & Bateman, R. J., Jun 2025, In: Nature medicine. 31, 6, p. 2044-2053 10 p., e76494.

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Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform

Palmqvist, S., Warmenhoven, N., Anastasi, F., Pilotto, A., Janelidze, S., Tideman, P., Stomrud, E., Mattsson-Carlgren, N., Smith, R., Ossenkoppele, R., Tan, K. B., Dittrich, A., Skoog, I., Zetterberg, H., Quaresima, V., Tolassi, C., Höglund, K., Brugnoni, D., Puig-Pijoan, A. & Fernández-Lebrero, A. & 10 others, Contador, J., Padovani, A., Monane, M., Verghese, P. B., Braunstein, J. B., Kern, S., Blennow, K., Ashton, N. J., Suárez-Calvet, M. & Hansson, O., Jun 2025, In: Nature medicine. 31, 6, p. 2036-2043 8 p.

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Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials

Ossenkoppele, R., Salvadó, G., Janelidze, S., Pichet Binette, A., Bali, D., Karlsson, L., Palmqvist, S., Mattsson-Carlgren, N., Stomrud, E., Therriault, J., Rahmouni, N., Rosa-Neto, P., Coomans, E. M., van de Giessen, E., van der Flier, W. M., Teunissen, C. E., Jonaitis, E. M., Johnson, S. C., Villeneuve, S. & Benzinger, T. L. S. & 10 others, Schindler, S. E., Bateman, R. J., Doecke, J. D., Doré, V., Feizpour, A., Masters, C. L., Rowe, C., Wiste, H. J., Petersen, R. C. & PREVENT-AD Research Group, May 2025, In: Nature Aging. 5, 5, p. 883-896 14 p., 2311.

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Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study

Janelidze, S., Collij, L. E., Mattsson-Carlgren, N., Antill, A., Laymon, C. M., Lott, I., Rosas, H. D., Minhas, D. S., Luo, W., Zaman, S., Mapstone, M., Head, E., Lai, F., Hartley, S. L., Ances, B. M., Krinsky-McHale, S. J., Lee, J. H. & Alzheimer's Biomarker Consortium–Down Syndrome investigators, 1 Jul 2025, In: Lancet Neurol.. 24, 7, p. 591-600 10 p.

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Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [18F]flortaucipir imaging: TAU-SPEX

Coomans, E. M., van Tol, B., Groot, C., Smith, R., Palmqvist, S., Stomrud, E., Pontecorvo, M. J., Shcherbinin, S., Kennedy, I., Kotari, V., van der Flier, W. M., Pijnenburg, Y. A. L., Mattsson-Carlgren, N., Hansson, O., van de Giessen, E. & Ossenkoppele, R., 2025, (E-pub ahead of print) In: European journal of nuclear medicine and molecular imaging.

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Survival Differences Between Individuals With Typical and Atypical Phenotypes of Alzheimer Disease

Bader, I., Groot, C., van der Flier, W. M., Pijnenburg, Y. A. L. & Ossenkoppele, R., 28 Apr 2025, In: Neurology. 104, 10, p. e213603 e213603.

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TREM2 risk variants and associated endophenotypes in alzheimer’s disease

Dijkstra, J. I. R., Vermunt, L., Venkatraghavan, V., Ozhegov, G., Coomans, E. M., Ossenkoppele, R., van de Giessen, E., Hulsman, M., de Geus, C. M., van der Flier, W. M., Sikkes, S. A. M., Barkhof, F., Tijms, B., Gouw, A. A., de Haan, W., Vijverberg, E. G. B., Pijnenburg, Y. A. L., Holstege, H., Teunissen, C. E. & van der Lee, S. J., 1 Dec 2025, In: Alzheimer's Research and Therapy. 17, 1, 57.

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2024

Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions

Freiburghaus, T., Pawlik, D., Oliveira Hauer, K., Ossenkoppele, R., Strandberg, O., Leuzy, A., Rittmo, J., Tremblay, C. C., Serrano, G. E., Pontecorvo, M. J., Beach, T. G., Smith, R. & Hansson, O., 1 Dec 2024, In: Acta neuropathologica. 148, 1, 44.

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Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder

Ho, N. C. W. & Lifespan Brain Chart Consortium, Aug 2024, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 9, 8, p. 786-799 14 p.

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Biological mechanisms of resilience to tau pathology in Alzheimer’s disease

Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O. & Ossenkoppele, R., 1 Dec 2024, In: Alzheimer's Research and Therapy. 16, 1, 221.

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Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care

Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G. & Hansson, O., 15 Oct 2024, In: JAMA. 332, 15, p. 1245-1257 13 p.

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Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study

Ulugut, H., Bertoux, M., Younes, K., Montembeault, M., Fumagalli, G. G., Samanci, B., Illán-Gala, I., Kuchcinski, G., Leroy, M., Thompson, J. C., Kobylecki, C., Santillo, A. F., Englund, E., Waldö, M. L., Riedl, L., van den Stock, J., Vandenbulcke, M., Vandenberghe, R., Laforce Jr, R. & Ducharme, S. & 21 others, Pressman, P. S., Caramelli, P., de Souza, L. C., Takada, L. T., Gurvit, H., Hansson, O., Diehl-Schmid, J., Galimberti, D., Pasquier, F., Miller, B. L., Scheltens, P., Ossenkoppele, R., van der Flier, W. M., Barkhof, F., Fox, N. C., Sturm, V. E., Miyagawa, T., Whitwell, J. L., Boeve, B., Rohrer, J. D. & International rtvFTD Working Group, Aug 2024, In: Alzheimer's and Dementia. 20, 8, p. 5647-5661 15 p.

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Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns

Crane, P. K., Groot, C., Ossenkoppele, R., Mukherjee, S., Choi, S.-E., Lee, M., Scollard, P., Gibbons, L. E., Sanders, R. E., Trittschuh, E., Saykin, A. J., Mez, J., Nakano, C., Donald, C. M., Sohi, H. & Risacher, S., 1 Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 1739-1752 14 p.

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Continuous β-Amyloid CSF/PET Imbalance Model to Capture Alzheimer Disease Heterogeneity

Alzheimer's Disease Neuroimaging Initiative on behalf of the AMYPAD consortium, 11 Jun 2024, In: Neurology. 103, 1, p. e209419 e209419.

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Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Chapleau, M., la Joie, R., Yong, K., Agosta, F., Allen, I. E., Apostolova, L., Best, J., Boon, B. D. C., Crutch, S., Filippi, M., Fumagalli, G. G., Galimberti, D., Graff-Radford, J., Grinberg, L. T., Irwin, D. J., Josephs, K. A., Mendez, M. F., Mendez, P. C., Migliaccio, R. & Miller, Z. A. & 19 others, Montembeault, M., Murray, M. E., Nemes, S. R., Pelak, V., Perani, D., Phillips, J., Pijnenburg, Y., Rogalski, E., Schott, J. M., Seeley, W., Sullivan, A. C., Spina, S., Tanner, J., Walker, J., Whitwell, J. L., Wolk, D. A., Ossenkoppele, R., Rabinovici, G. D. & PCA International Work Group, 1 Feb 2024, In: The Lancet Neurology. 23, 2, p. 168-177 10 p.

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Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Mastenbroek, S. E., Vogel, J. W., Collij, L. E., Serrano, G. E., Tremblay, C. C., Young, A. L., Arce, R. A., Shill, H. A., Driver-Dunckley, E. D., Mehta, S. H., Belden, C. M., Atri, A., Choudhury, P., Barkhof, F., Adler, C. H., Ossenkoppele, R., Beach, T. G. & Hansson, O., 1 Dec 2024, In: Nature communications. 15, 1, 5133.

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Disease staging of Alzheimer’s disease using a CSF-based biomarker model

Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J. & Hansson, O., May 2024, In: Nature Aging. 4, 5, p. 694-708 15 p.

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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model

Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., Olafson, E., Baker, S., Saad, Z. S., Bullich, S., Lopresti, B., Bohorquez, S. S., Boada, M., Betthauser, T. J., Charil, A., Collins, E. C., Collins, J. A., Cullen, N., Gunn, R. N., Higuchi, M. & Hostetler, E. & 30 others, Hutchison, R. M., Iaccarino, L., Insel, P. S., Irizarry, M. C., Jack, C. R., Jagust, W. J., Johnson, K. A., Johnson, S. C., Karten, Y., Marquié, M., Mathotaarachchi, S., Mintun, M. A., Ossenkoppele, R., Pappas, I., Petersen, R. C., Rabinovici, G. D., Rosa-Neto, P., Schwarz, C. G., Smith, R., Stephens, A. W., Whittington, A., Carrillo, M. C., Pontecorvo, M. J., Haeberlein, S. B., Dunn, B., Kolb, H. C., Sivakumaran, S., Rowe, C. C., Hansson, O. & Doré, V., Sept 2024, In: Alzheimer s & dementia. 20, 9, p. 5833-5848 16 p.

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Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study

Soleimani-Meigooni, D. N., Smith, R., Provost, K., Lesman-Segev, O. H., Allen, I. E., Chen, M. K., Cho, H., Edwards, L., Janelidze, S., la Joie, R., Mundada, N., Ossenkoppele, R., Stomrud, E., Strandberg, O., Strom, A., Boxer, A. L., Dage, J. L., Gorno-Tempini, M. L., Kramer, J. H. & Miller, B. L. & 5 others, Rojas, J. C., Rosen, H. J., Lyoo, C. H., Hansson, O. & Rabinovici, G. D., 1 Sept 2024, In: Annals of neurology. 96, 3, p. 476-487 12 p.

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Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests

Barthélemy, N. R., Salvadó, G., Schindler, S. E., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., la Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E. & Bateman, R. J. & 1 others, Hansson, O., Apr 2024, In: Nature medicine. 30, 4, p. 1085-1095 11 p.

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Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease

Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R. & Hansson, O., 1 Dec 2024, In: Nature communications. 15, 1, 8061.

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Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer's disease

Baril, A.-A., Picard, C., Labonté, A., Sanchez, E., Duclos, C., Mohammediyan, B. R., Breitner, J. C. S., Villeneuve, S., Poirier, J., Dadar, M., Chakravarty, M., Spreng, N., Bohbot, V. R., Collins, L., Evans, A., Hoge, R., Near, J., Rajah, N., Soucy, J.-P. & Baillet, S. & 30 others, Poirier, J., Auld, D., Multhaup, G., Cuello, C., Morgan, D. G., Arbour, N., Breitner, J., Geddes, M., Ducharme, S., Meyer, P.-F., Rosa-Neto, P., Das, S., Madjar, C. C., Kat, J., Tremblay-Mercier, J., Dyke, S., Iturria Medina, Y., Leoutsakos, J.-M., Blennow, K., Zetterberg, H., Mielke, M. M., Ossenkoppele, R., Amouyel, P., Tullo, S., Vachon-Presseau, É., Tardif, C., Münter, L.-M., Orban, P., Fonov, V. & Newbold, H., 1 Jun 2024, In: Sleep. 47, 6, zsae081.

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Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline

Calandri, I. L., Ardohain, C. A., Elgani, S. A., Seminara, E., Hernandez, M. A., Ossenkoppele, R. & Allegri, R. F., 1 Oct 2024, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 16, 4, e12538.

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Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies

Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S. & Hansson, O., 8 Jan 2024, In: JAMA Neurology. 81, 1, p. 69-78 10 p.

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Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Bader, I., Groot, C., Tan, H. S., Milongo, J. M. A., Haan, J. D., Verberk, I. M. W., Yong, K., Orellina, J., Campbell, S., Wilson, D., van Harten, A. C., Kok, P. H. B., van der Flier, W. M., Pijnenburg, Y. A. L., Barkhof, F., van de Giessen, E., Teunissen, C. E., Bouwman, F. H. & Ossenkoppele, R., Dec 2024, In: Alzheimer's Research and Therapy. 16, 1, 190.

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Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina

Calandri, I. L., Livingston, G., Paradela, R., Ossenkoppele, R., Crivelli, L., Allegri, R. F. & Suemoto, C. K., 1 Aug 2024, In: Neuroepidemiology. 58, 4, p. 264-275 12 p.

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Survey among experts on the future role of tau-PET in clinical practice and trials

Vermeiren, M. R., Calandri, I. L., van der Flier, W. M., van de Giessen, E. & Ossenkoppele, R., 1 Oct 2024, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 16, 4, e70033.

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Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment

Groot, C., Smith, R., Collij, L. E., Mastenbroek, S. E., Stomrud, E., Binette, A. P., Leuzy, A., Palmqvist, S., Mattsson-Carlgren, N., Strandberg, O., Cho, H., Lyoo, C. H., Frisoni, G. B., Peretti, D. E., Garibotto, V., la Joie, R., Soleimani-Meigooni, D. N., Rabinovici, G., Ossenkoppele, R. & Hansson, O., 12 Aug 2024, In: JAMA Neurology. 81, 8, p. 845-856 12 p.

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The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study

Vermeiren, M. R., Somsen, J., Luurtsema, G., Reesink, F. E., Verwey, N. A., Hempenius, L., Tolboom, N., Biessels, G. J., Biesbroek, J. M., Vernooij, M. W., Veldhuijzen van Zanten, S. E. M., Seelaar, H., Coomans, E. M., Teunissen, C. E., Lemstra, A. W., van Harten, A. C., Visser, L. N. C., van der Flier, W. M., van de Giessen, E. & Ossenkoppele, R., 1 Dec 2024, In: Alzheimer's Research and Therapy. 16, 1, 230.

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The implications of amyloid-β pathology: only time will tell

Coomans, E. M. & Ossenkoppele, R., 1 Jun 2024, In: Brain. 147, 6, p. 1934-1936 3 p.

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2023

A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum

Coomans, E. M., Verberk, I. M. W., Ossenkoppele, R., Verfaillie, S. C. J., Visser, D., Gouda, M., Tuncel, H., Wolters, E. E., Timmers, T., Windhorst, A. D., Golla, S. S. V., Scheltens, P., van, W. M., Flier, D., van Berckel, B. N. M. & Teunissen, C. E., 1 Mar 2023, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 64, 3, p. 437-443 7 p.

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Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex

van Engelen, M.-P. E., Verfaillie, S. C. J., Dols, A., Oudega, M. L., Boellaard, R., Golla, S. S. V., den Hollander, M., Ossenkoppele, R., Scheltens, P., van Berckel, B. N. M., Pijnenburg, Y. A. L. & Vijverberg, E. G. B., 2023, In: EJNMMI research. 13, 1, 71.

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Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population

Collij, L. E., Farrar, G., Zwan, M., van de Giessen, E., Ossenkoppele, R., Barkhof, F., Rozemuller, A. J. M., Pijnenburg, Y. A. L., van der Flier, W. M. & Bouwman, F., 1 Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 207.

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Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease

Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N. & Ewers, M., 2023, (E-pub ahead of print) In: Annals of neurology.

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Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease

Leuzy, A., Binette, A. P., Vogel, J. W., Klein, G., Borroni, E., Tonietto, M., Strandberg, O., Mattsson-Carlgren, N., Palmqvist, S., Pontecorvo, M. J., Iaccarino, L., Stomrud, E., Ossenkoppele, R., Smith, R. & Hansson, O., 12 Jun 2023, In: JAMA Neurology. 80, 6, p. 614-623 10 p.

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CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C. & Mattsson-Carlgren, N. & 5 others, Stomrud, E., Ossenkoppele, R., Schindler, S. E., Hansson, O. & Bateman, R. J., Aug 2023, In: Nature medicine. 29, 8, p. 1954-1963 10 p.

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Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M.-Y., Lee, E. B. & Hansson, O., 1 Jul 2023, In: Brain. 146, 7, p. 2975-2988 14 p.

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Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis

Alzheimer’s Disease Neuroimaging Initiative, 1 Sept 2023, In: Brain. 146, 9, p. 3719-3734 16 p.

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Effects of the DICE Method to Improve Timely Recognition and Treatment of Neuropsychiatric Symptoms in Early Alzheimer's Disease at the Memory Clinic: The BEAT-IT Study

Eikelboom, W. S., van den Berg, E., Coesmans, M., Goudzwaard, J. A., Koopmanschap, M., Lazaar, N., van Bruchem-Visser, R. L., Driesen, J. J. M., den Heijer, T., Hoogers, S., de Jong, F. J., Mattace-Raso, F., Thomeer, E. C., Vrenken, S., Vroegindeweij, L. J. H. M., Zuidema, S. U., Singleton, E. H., van Swieten, J. C., Ossenkoppele, R. & Papma, J. M., 13 Jun 2023, In: Journal of Alzheimer's Disease. 93, 4, p. 1407-1423 17 p.

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Rik Ossenkoppele

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