Personal profile
Specialisation
Pathology/neuro-oncological pathology
Research interests
- Unraveling the molecular underpinnings of primary tumors of the central nervous system (CNS);
- Translation of these findings in improved clinical diagnosis and classification of CNS tumors;
- Elucidation of the role of the tumor microenvironment in the pathobiology and clinical behavior of CNS tumors.
Pieter Wesseling is a (neuro)pathologist and full professor at the department of Pathology at the Amsterdam UMC, and he is additionally affiliated with the Princess Máxima Center for Pediatric Oncology in Utrecht. Wesseling was trained as clinical (neuro)pathologist in the Radboud University Medical Center in Nijmegen (supervised by Prof. Joop L. Slooff), and in Duke University Medical Center in Durham NC, USA (Prof. Peter C. Burger. He has led multiple (inter)national research projects, (co-)authored more than 300 papers in international, peer-reviewed journals on neuro-oncological topics, is member of the editorial board of several international neuro-oncological and neuropathological journals. He is at present chair of the consortium to Improve Molecular and Practical Approaches for CNS tumor Taxonomy (cIMPACT-NOW) Steering Committee, was centrally involved in shaping the revised 4th edition of the WHO CNS tumor classification (2016) and is an expert editor of the 5th (2021) edition of this classification as well as of the WHO classification of Pediatric Tumors (2022).
Activities
- Expert member of the editorial board of the WHO 2021 Classification of CNS tumors
- Chair of the consortium to Improve Molecular and Practical Approaches to CNS Tumor Taxonomy/cIMPACT-NOW (link)
- Chair of the International Collaboration of Cancer Reporting (Neuropathology branch)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors
Wesseling, P., Capper, D., Reifenberger, G., Sarkar, C., Hawkins, C., Perry, A., Kleinschmidt-DeMasters, B., Komori, T., Paulus, W., Santosh, V., van den Bent, M., Weller, M., Pfister, S. M., Tabori, U., Figarella-Branger, D., Orr, B. A. & Louis, D. N., Jan 2026, In: Brain Pathology. 36, 1, e70035.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Downloads (Pure) -
Concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): final and exploratory analyses of a randomised, open-label, phase 3 trial
van den Bent, M. J., Ghisai, S. A., Wick, W., Sanson, M., Brandes, A. A., Clement, P. M., Erridge, S. C., Vogelbaum, M. A., Nowak, A. K., Baurain, J.-F., Mason, W. P., Wheeler, H., Tabouret, E., Gill, S., Griffin, M., Taal, W., Rudà, R., Weller, M., McBain, C. & Reijneveld, J. C. & 21 others, , 1 Jan 2026, In: lancet oncology. 27, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Chromosome 1p Loss and 1q Gain for Grading of Meningioma
Landry, A. P., Wang, J. Z., Patil, V., Liu, J., Gui, C., Ellenbogen, Y., Ajisebutu, A., Yefet, L., Wei, Q., Singh, O., Sosa, J., Mansouri, S., Cohen-Gadol, A. A., Tabatabai, G., Tatagiba, M., Behling, F., Barnholtz-Sloan, J. S., Sloan, A. E., Chotai, S. & Chambless, L. B. & 14 others, , 20 Jun 2025, In: JAMA oncology. 11, 6, p. 644-649 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Downloads (Pure) -
cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification
Hawkins, C., Aldape, K., Capper, D., von Deimling, A., Giannini, C., Gilbert, M. R., Jacques, T. S., Jones, D., Komori, T., Louis, D. N., Mueller, S., Nasrallah, M., Orr, B. A., Perry, A., Pfister, S. M., Sahm, F., Sarkar, C., Snuderl, M., Solomon, D. & Varlet, P. & 2 others, , Nov 2025, In: Brain Pathology. 35, 6, e70018.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open AccessFile10 Downloads (Pure) -
cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas
Sahm, F., Aldape, K. D., Brastianos, P. K., Brat, D. J., Dahiya, S., von Deimling, A., Giannini, C., Gilbert, M. R., Louis, D. N., Raleigh, D. R., Reifenberger, G., Santagata, S., Sarkar, C., Zadeh, G., Wesseling, P. & Perry, A., 1 Feb 2025, In: Neuro-oncology. 27, 2, p. 319-330 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile37 Downloads (Pure)