Personal profile
Research interests
* Contribution of the LXR-IDOL-LDLR axis to cholesterol metabolism
* Identification of novel metabolic genes
* Studying the contribution of the UPS system to metabolism
Specialisation
Transcriptional regulation of metabolism
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Dive into the research topics where Noam Zelcer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein
Sorrentino, V., Fouchier, S. W., Motazacker, M. M., Nelson, J. K., Defesche, J. C., Dallinga-Thie, G. M., Kastelein, J. J. P., Kees Hovingh, G. & Zelcer, N., 2013, In: European heart journal. 34, 17, p. 1292-1297Research output: Contribution to journal › Article › Academic › peer-review
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The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL
Nelson, J. K., Sorrentino, V., Avagliano Trezza, R., Heride, C., Urbe, S., Distel, B. & Zelcer, N., 5 Feb 2016, In: Circulation research. 118, 3, p. 410-9 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile32 Downloads (Pure) -
Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism
Lu, X., Meima, M. E., Nelson, J. K., Sorrentino, V., Loregger, A., Scheij, S., Dekkers, D. H. W., Mulder, M. T., Demmers, J. A. A., M-Dallinga-Thie, G., Zelcer, N. & Danser, A. H. J., 2016, In: Circulation research. 118, 2, p. 222-229Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure) -
The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway
Zelcer, N., Sharpe, L. J., Loregger, A., Kristiana, I., Cook, E. C. L., Phan, L., Stevenson, J. & Brown, A. J., 2014, In: Molecular and cellular biology. 34, 7, p. 1262-1270Research output: Contribution to journal › Article › Academic › peer-review
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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
Zelcer, N., Hong, C., Boyadjian, R. & Tontonoz, P., 2009, In: Science. 325, 5936, p. 100-104Research output: Contribution to journal › Article › Academic › peer-review