Unexplained subfertility

The research programme focuses on the evaluation of therapy of couples with Unexplained subfertility and male factor subfertility. A distinction is made between women younger than 38 years of age and older, since age is a predominate factor in the changes to become pregnant. The research will be performed  in multicenter national setting (Dutch Fertility Consortium) Unexplained subfertility will be investigated with regard to diagnostic strategies and expectant management. The applicant is the principal investigator of a current randomised study comparing different ovarian hyperstimulation medication for the first line treatment of these couples i.e. Intra uterine insemination. In 2015 two more multicentre studies will be started comparing the standard treatment IUI for younger women, IVF for older women to expectant management. Next to efficacy, patients preferences and implementing expectant management will be the focus of these studies.

Male factor subfertility

The second research line focuses on male factor subfertility a distinction is made in mild male factor and severe male factor. In couples in whom the man suffers from azoospermia, surgically removed sperm is used for ICSI treatment. In case this treatment fails, treatment with donor semen can be an alternative. The applicant is principal investigator of a randomised study comparing intra-cervical insemination of donor sperm to intra uterine insemination.

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