Personal profile
Research interests
Dirk Michiel Pegtel PhD. While an undergraduate student Michiel (University of Groningen, The Netherlands) conducted practical training at the National Cancer Institute (Bethesda, USA) with Dr John J. Letterio and obtained a PhD in Immunology at Tufts University Medical School (Boston, USA) with Prof David Thorley Lawson working on Epstein Barr Virus induced cancers in collaboration with members of the MIT/Harvard Broad Institute (Cambridge, USA). After postdoctoral training at the Netherlands Cancer Institute with Dr John Collard working on tumorcell biology behaviour and relationship with Epstein Barr virus in Lymphomas and autoimmune disease with Prof J. Middeldorp (VUmc, The Netherlands), Michiel started the "Exosomes Research Group" at the Amsterdam UMC/Cancer Center Amsterdam. Current members of the ERG study i) the molecular dynamics of exosome biogenesis and release ii) small RNA sorting into exosomes with the purpose of developing liquid biopsy strategies and iii) exploiting exosomes and EVs for therapeutic delivery. For his early discovery of functional transfer of exosome-bound miRNAs, Michiel was awarded the Beijerinck Premium by the Royal Dutch Academy of Sciences (KNAW). Michiel is an inventor of multiple patents and co-founder of ExBiome B.V. a molecular small RNA diagnostics start-up that aims to develop liquid biopsy tests to predict response to therapy early such that clinicians are better informed on the efficacy of treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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Collaborations and top research areas from the last five years
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Cell-Free DNA Based Next-Generation Sequencing Does Not Differentiate Between Oligoprogression and Systemic Progression in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors—An Explorative Study
Rozendal, P., Kievit, H., van der Leest, P., Bahce, I., Pegtel, M., Groen, H. J. M., van Kempen, L. O. C., Hiltermann, T. J. N. & Schuuring, E., 1 Aug 2025, In: International journal of molecular sciences. 26, 16, 8087.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Downloads (Pure) -
Circulating extracellular vesicle isomiR signatures predict therapy response in patients with multiple myeloma
Gómez-Martín, C., Drees, E. E. E., van Eijndhoven, M. A. J., Groenewegen, N. J., Wang, S., Verkuijlen, S. A. W. M., van Weering, J. R. T., Aparicio-Puerta, E., Bosch, L., Frerichs, K. A., Verkleij, C. P. M., Kersten, M. J., Zijlstra, J. M., de Jong, D., Groothuis-Oudshoorn, C. G. M., Hackenberg, M., de Rooij, J. R., van de Donk, N. W. C. J. & Pegtel, D. M., 21 Oct 2025, In: Cell Rep. Med.. 6, 10, 102358.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure) -
Extracellular Vesicle-Derived miRNA Signatures in Peritoneal Dialysis Effluent as Biomarkers of Peritoneal Health in Patients Treated with Peritoneal Dialysis
Karsten, M., Gómez Martín, C., Groenewegen, N. J., de Rooij, J., Vervloet, M., Pegtel, D. M. & L, J., 20 Dec 2025, (Submitted) In: Journal of Extracellular Vesicles.Research output: Contribution to journal › Article › Academic › peer-review
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Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome
Schwarzmueller, L. J., Adam, R. S., Moreno, L. F., Nijman, L. E., Logiantara, A., Eleonora, S., Bril, O., Vromans, S., De Groot, N. E., Giugliano, F. P., Stepanova, E., Muncan, V., Elbers, C. C., Lenos, K. J., Zwijnenburg, D. A., Van Eijndhoven, M. A. J., Pegtel, D. M., Van Neerven, S. M., Loayza-Puch, F. & Dadali, T. & 5 others, , 1 Apr 2025, In: Gut. 74, 4, p. 571-585 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used for Liquid Biopsy Based Diagnostics
Asif, P. J., Borghuis, L. H., van Hooff, S. R., Grootemaat, A. E., van Eijndhoven, M. A. J., de Rooij, J., Groenewegen, N. J., Boza, J. P., Kranenburg, O., Rinkes, I. H. M. B., Gómez-Martín, C., Pruijt, H. F. M., van der Wel, N. N., Torang, A., Buffart, T. E., Pegtel, D. M. & Medema, J. P., 1 Nov 2025, In: Journal of extracellular vesicles. 14, 11, e70171.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Downloads (Pure)
Activities
- 2 Oral presentation
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Peritoneal Dialysis (PD) Effluent Derived Extracellular Vesicles to Establish PD-Induced Peritoneal Alterations’
Karsten, M. (Speaker), Vervloet, M. (Speaker), Pegtel, M. (Speaker) & Jakulj, L. (Speaker)
28 Nov 2023Activity: Talk or presentation › Oral presentation › Academic
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Peritoneal Dialysis (PD) Effluent Derived Extracellular Vesicles to Establish PD-Induced Peritoneal Alterations’
Karsten, M. (Speaker), Vervloet, M. (Speaker), Pegtel, M. (Speaker) & Jakulj, L. (Speaker)
17 Jun 2023Activity: Talk or presentation › Oral presentation › Academic
Prizes
Press/Media
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Onderzoek naar kanker kan niet zonder patiënten: 'Als iedereen "nee" zegt, komen we niet verder'
15/03/2018
1 Media contribution
Press/Media: exportcomment
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