Projects per year
Personal profile
Research interests
Dirk Michiel Pegtel PhD. While an undergraduate student Michiel (University of Groningen, The Netherlands) conducted practical training at the National Cancer Institute (Bethesda, USA) with Dr John J. Letterio and obtained a PhD in Immunology at Tufts University Medical School (Boston, USA) with Prof David Thorley Lawson working on Epstein Barr Virus induced cancers in collaboration with members of the MIT/Harvard Broad Institute (Cambridge, USA). After postdoctoral training at the Netherlands Cancer Institute with Dr John Collard working on tumorcell biology behaviour and relationship with Epstein Barr virus in Lymphomas and autoimmune disease with Prof J. Middeldorp (VUmc, The Netherlands), Michiel started the "Exosomes Research Group" at the Amsterdam UMC/Cancer Center Amsterdam. Current members of the ERG study i) the molecular dynamics of exosome biogenesis and release ii) small RNA sorting into exosomes with the purpose of developing liquid biopsy strategies and iii) exploiting exosomes and EVs for therapeutic delivery. For his early discovery of functional transfer of exosome-bound miRNAs, Michiel was awarded the Beijerinck Premium by the Royal Dutch Academy of Sciences (KNAW). Michiel is an inventor of multiple patents and co-founder of ExBiome B.V. a molecular small RNA diagnostics start-up that aims to develop liquid biopsy tests to predict response to therapy early such that clinicians are better informed on the efficacy of treatment.
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Collaborations and top research areas from the last five years
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Exploring the potential of tRNA molecules: Exploring the potential of tRNA molecules in urine and self-swabs as non-invasive markers for cervical cancer detection
Pegtel, M. (Principal investigator) & Scheepbouwer, C. (Project Leader)
NWO: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
01/04/2025 → 31/03/2026
Project: Research
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CCA2023-9-93: An exploratory extracellutar vesicle based immuno-monitoring method to detect signals from tissue-resident immune cells
Pegtel, M. (Principal investigator) & Gómez Martín, C. (Project Leader)
Stichting Cancer Center Amsterdam
01/08/2024 → 31/07/2026
Project: Research
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PP 32502 CCA2023-9-93: An exploratory extracellutar vesicle based immuno-monitoring method to detect signals from tissue-resident immune cells
Pegtel, M. (Principal investigator) & Gómez Martín, C. (Project Leader)
Stichting Cancer Center Amsterdam
01/08/2024 → 31/07/2026
Project: Research
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MRD-assay sensitivity: Increasing MRD-assay sensitivity
Pegtel, M. (Principal investigator)
01/06/2024 → 31/12/2026
Project: Research
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KWF 14976: KWF 14976
Pegtel, M. (Principal investigator) & Moulière, F. (Project Leader)
01/10/2023 → 30/09/2027
Project: Research
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Choice of size-exclusion chromatography column affects recovery, purity, and miRNA cargo analysis of extracellular vesicles from human plasma
Bracht, J. W. P., Los, M., van der Pol, E., Verkuijlen, S. A. W. M., van Eijndhoven, M. A. J., Pegtel, D. M. & Nieuwland, R., 1 Sept 2024, In: Extracellular Vesicles and Circulating Nucleic Acids. 5, 3, p. 597-608 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Comparison of cell-free and small extracellular-vesicle-associated DNA by sequencing plasma of lung cancer patients
Moldovan, N., Verkuijlen, S., van der Pol, Y., Bosch, L., van Weering, J. R. T., Bahce, I., Pegtel, D. M. & Mouliere, F., 20 Sept 2024, In: iScience. 27, 9, 110742.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles
Scheepbouwer, C., Aparicio-Puerta, E., Gómez-Martin, C., van Eijndhoven, M. A. J., Drees, E. E. E., Bosch, L., de Jong, D., Wurdinger, T., Zijlstra, J. M., Hackenberg, M., Gerber, A. & Pegtel, D. M., 12 May 2024, In: bioRxiv.Research output: Contribution to journal › Article › Academic
Open AccessFile1 Downloads (Pure) -
G protein-coupled receptors: a gateway to targeting oncogenic EVs?
di Niro, L., Linders, A. C., Glynn, T., Pegtel, D. M., Siderius, M., Crudden, C. & Smit, M. J., 2024, In: Extracellular Vesicles and Circulating Nucleic Acids. 5, 2, p. 233-248 16 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure) -
Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes
Viola, M., Bebelman, M. P., Maas, R. G. C., de Voogt, W. S., Verweij, F. J., Seinen, C. S., de Jager, S. C. A., Vader, P., Pegtel, D. M. & Petrus Gerardus Sluijter, J., 1 Nov 2024, In: Journal of extracellular vesicles. 13, 11, e70000.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure)
Prizes
Press/Media
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Onderzoek naar kanker kan niet zonder patiënten: 'Als iedereen "nee" zegt, komen we niet verder'
15/03/2018
1 Media contribution
Press/Media: exportcomment
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