Amsterdam UMC Department of Neurology

The Department of Neurology performs clinical and translational research within multiple research themes: neurologic infections & inflammatory disorders, cerebrovasculair disease, dementia, multiple sclerosis , neuro-oncology, neuromuscular disorders and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

Infection & Inflammation

We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.

Prof. Dr. Matthijs C. Brouwer

The focus of Prof. Brouwer’s research is on neurological infectious diseases, including clinical characteristics, genetics, diagnostics, treatment and outcome of bacterial meningitis, viral meningitis, chronic meningitis and neuroborreliosis. To this aim he has set up a nation-wide genetic association study on community-acquired bacterial meningitis (MeninGene study) and a study on suspected meningitis and encephalitis patients (I-PACE study). Prof. Brouwer is national coordinator for the  international randomized controlled trial on brain abscess treatment with oral antibiotics (ORAL trial), led by Dr. Bodilsen, Aalborg, DK.

In addition to infections of the CNS, prof. Brouwer also leads or participates in research projects on CSF circulation disorders such as the spontaneous intracranial hypotension syndrome, and inflammatory diseases of the nervous system such as neurosarcoidosis and cerebral vasculitis. 

Spontaneous intracranial hypotension syndrome