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Martin Klein

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Martin Klein

PROF.DR., Principal Investigator

 https://orcid.org/0000-0003-4160-5746
  • 10081
    Citations
1996 …2026

Research activity per year

Personal profile

Specialisation

Medical Neuropsychology

Research interests

Martin Klein is a clinical neuropsychologist and professor in medical neuropsychology at the Amsterdam UMC and Vrije Universiteit Amsterdam in the Netherlands. His research, in close cooperation with the departments of neurology, neurosurgery, and radiation oncology, focuses on several aspects:

Neurocognitive Functioning and Quality of Life in high-grade glioma patients

Initially research focused on determining neurocognitive functioning and health-related quality of life of patients with brain tumors. This resulted in influential papers on neurocognitive functioning and health-related quality of life of high-grade glioma patients at the time of diagnosis, at follow-up, at the time of recurrence, and on the prognostic value of neurocognitive functioning.

Impact of Treatment on Low-Grade Glioma and Neurological Patients

Regarding low-grade glioma patients, and other neurological patients, studies on the impact of surgery, radiotherapy, and on epilepsy and antiepileptic drugs on neurocognitive functioning and health-related quality of life are ongoing. The effectiveness of cognitive rehabilitation in patients with focal seizures has been addressed in a number of studies.

Understanding Brain Mechanisms Underlying Neurological Symptoms

Currently research aims at determining the brain mechanisms underlying frequent symptoms (e.g., neurocognitive deficits, epilepsy, fatigue, depression), the prevention of treatment effects on neurocognitive functioning, and on behavioral or pharmaceutical symptom treatment in primary and metastatic brain tumor patients and in oncological patients undergoing neurotoxic treatments affecting brain functioning.

Activities

Within the European Organization for the Research and Treatment of Cancer (EORTC), Martin Klein is entrusted with the scientific management of cognitive assessments across approximately 90 participating centers in Europe, contributing significantly to the clinical trials initiated by the EORTC Brain Tumor Group.

In 2023, Martin Klein extended his expertise to the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), contributing to the global assessment and reporting of radiation exposure levels and their effects, and helping to establish protective measures based on these evaluations.

Awards

  • Received the Tim & Tom Gullikson Foundation and Society for Neuro-Oncology Award for Excellence in Quality of Life Research in 2001
  • Honored with the National Brain Tumor Foundation/Tug McGraw Foundation Caregiver Research Award in 2008
  • Awarded the Excellence of Applied Neuro-Oncology in 2017



 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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  • Bayesian adaptive randomized trial of blended cognitive behavioral therapy for severe fatigue in stable diffuse glioma

    Gorter, M., Röttgering, J. G., Belgers, V., Blom, M. E. C., Thomassen, B., De Witt Hamer, P. C., Niers, J. M., Kouwenhoven, M. C. M., Bienfait, H. P., Gathier, C. S., Compter, A., Geurts, M., Snijders, T. J., van de Ven, P. M., Douw, L., Knoop, H. & Klein, M., Mar 2026, In: Neuro-oncology. 28, 3, p. 693-703 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    7 Downloads (Pure)

  • Improving fatigue and neurocognitive impairment in progressive neurological disorders: a systematic and narrative review

    Röttgering, J. G., Choi, E., Douw, L., de Vries, R., Brie, M., Taylor, J. W., Klein, M. & Weyer-Jamora, C., 1 Jan 2026, In: Heliyon. 12, 1, e44183.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    36 Downloads (Pure)

  • Influence of Age in End-of-Life Practices in Worldwide ICUs (ETHICUS-2): A Prospective Observational Study

    Nagata, I., Sprung, C. L., Lautrette, A., Jaschinski, U., Mullick, S., Aggarwal, A., Pantazopoulos, I., Anstey, M. H., Jensen, H. I., Karlis, G., Marliere, M. H., Tsagkaris, I., Montiel, B. E., Barrachina, L. G., Weiss, M., Romain, M., Nunnally, M. E., Cerny, V., Piras, C. & Miskolci, O. & 341 others, Barth, E., Ricou, B., Avidan, A., ETHICUS-2 Study Group, Sprung, C., Bernstein, R., Avidan, A., Baras, M., Gruber, A., Posch, M., de la Guardia, V., Sprung, C. L., Anstey, M., Avidan, A., Azoulay, E., Benbenishty, J., Bin, D., Cook, D., Randall Curtis, J., Feldman, C., Hartog, C., Joynt, G., Kainuma, M., Levy, M., Mani, R. K., Michalsen, A., Ricou, B., Soares, M., Truog, R., Juliarena, A., Philpot, S., Sarode, V., Barrett, J., Hanlon, G., Botha, J., Green, C., Blackwell, N., Lavana, J., Sharrock, J., Anstey, M., Roberts, B., Santamaria, J., Azad, R., Smith, R., Garrett, P., Brailsford, J., Buckley, A., Forbes, L., Murray, L., Wilson, A., Ledoux, D., Ingels, C., Ferreira, R., Lobo, S., Dias, F. S., Formolo, F., Zerman, L., Knibel, M., Piras, C., Caser, E., Damasceno, S., Huanzhang, S., Bin, D., Ming, H., Chuanyun, Q., Haiying, W., Yuanyuan, L., Xuejuan, W., Zhengxuan, L., Baldimir, G., Ruz, A., Atehortua, A. M., Kakoullis, S., Loizou, A., Mixides, G., Novy, J., Cerna Parizkova, R., Cerny, V., Benes, J., Jobanek, J., Parizek, T., Tyll, T., Goldinger, M. P., Gjedsted, J., Kristensen, S. S., Jensen, H. I., Christensen, L., Bülow, H. H., Marliere, M. H., Yunen, J., Ramos, J., Henriquez, C., Rigaud, J. P., Lautrette, A., Lesieur, O., Reignier, J., Darmon, M., Demoule, A., Delahaye, A., Azoulay, E., Souppart, V., Garrouste-Orgeas, M., Eon, B., Bourenne, J., Dey, K., Buchholzer, K., Markoff, S., Schmidt, K., Falk, E., Sonnemann, S., Spies, C., Goldmann, A., Laetsch, B., Michalsen, A., Frommlett, B., Jaschinski, U., Kreuzer, I., Ortmann, J., Bone, H. G., Briegel, J., Strupp, E., Bercker, S., Ragaller, M., Gottschlich, B., Reisbach, L., Reising, A., Schlegel, C., Simon, P., Ulbricht, U., Hartog, C., Anca, I. A., Bloos, P., Haucke, A., Kharel, S., Kolanos, S., Kunsch, H., Schwarzkopf, S., Weiss, M., Barth, S., Barth, E., Bracht, H., Riessen, R., Haap, M., Heigl, A., Ragaller, M., Gottschlich, B., Reisbach, L., Ulbricht, A., Mathas, C., Armaganidis, A., Mavrou, I., Tsagkaris, I., Zakynthinos, S., Mentzelopoulos, S., Kotanidou, A., Kokkoris, S., Pantazopoulos, I., Karlis, G., Papanikolaou, M., Karaouli, V., Karatzas, S., Antonakis, V., Nakos, G., Koulouras, V., Ntalouka, M., Papathanakos, G., Pneumatikos, I., Kouliatsis, G., Petala, A., Zakinthinos, E., Koutsothymiou, K., Chow, F. L., Wong, M., Sy, L., Chang, L., Joynt, G., Mac, W. K., So, D., Chan, W. M., Leung, E., Ling Kin Ho, S., Chan, K. C., Kwan, W. M. G., Csomós, A., Domján, A., Elo, G., Szűcs, O., Zubek, L., Bobek, I., Filipe, M., Hragyil, K., Perecz, Z., Rudenko, V., Mullick, S., Walshe, C., Isaac, E., Reidy, B., Collins, N., Condon, E., Maguire, S., Tierney, A., Seigne, P., Connolly, L., Aguiar, F., Collins, D., Martin-Loeches, I., Naylor, E., Miskolci, O., O’Loughlin, C., Motherway, C., Mundinaite, A., Jakobson, D., Michal, N., Singer, P., Kagan, I., Eden, A., Erport, A., Sprung, C., Sviri, S., Avidan, A., Bernstein, R., de la Guardia, V., Farran, A., Romain, M., van Heerden, V., Finkelstein, R., Paz, E., Levin, P., Alon, N., Haviv, Y., Klein, M., Brotfain, E., de Blasio, E., Galzerano, A., Malacarne, P., David, A., Noto, A., Marzi, U., Protti, A., Russo, R., Palo, A., Cortesi, S., Guarisco, S., Lusito, F., Flocco, R., Pozone, T., Martani, L., Geat, E., Panozzo, M., Lago, S., Zanardo, G., Livigni, S., Vergano, M., Bocci, M. G., Antonelli, M., Gori, F., Gando, S., Ohshimo, S., Yamaga, S., Hashimoto, K., Kainuma, M., Sawamura, T., Norisue, Y., Fujiwara, S., Nagata, I., Sierra Unzueta, A. F., Vazquez Mathieu, J. P., Gomez, J. M., Miranda-Ackerman, R. C., Gerritsen, R., Koopmans, M., Enschede, B., Soliman, I., van Dijk, D., Girbes, A., Alberts, E., Kazemi, A., Tilsley, A., Browne, T., Goodson, J., Osinaike, B., Akinyemi, O. A., Idowu, O. K., Sanusi, A., Unal, N., Ozcelik, M., Peker, T., Esen, F., Ozcan, P. E., Yenigun, O., Dikmen, Y., Cinel, I., Kahveci, F., Cizmeci, E. A., Cosgrove, J., O’Neill, S., McKechnie, S., Armstrong, E., Hutton, P., Smythe, J., Kapoor, R., Cullinane, J., Plowright, C., Box, R., Coetzee, S., Pegg, C., Alegria, A., Whitney, S., Danbury, C., Bryden, D. C., Cruikshanks, A., Wimbush, S., Attwood, B., Mason, S., Parsons, P., Smith, A., Webb, K., Webb, K., Lakhani, S., Brealey, D., Stoyanova, R., Tam, K., Standley, T., Sreedharan, R., Roberts, L., Perez-Protto, S., Khanna, A. K., Aggarwal, A., Hough, T., Dean, S., Katsandres, S., Ungar, A., Chen, E., Doyle, A., Nates, J., Ovu, S., Nunnally, M., Healy, E., Simpson, S., Riegel, E. & Homan, M., Apr 2026, In: Critical care medicine. 54, 4, p. 701-714 14 p., 10.1097/CCM.0000000000007091.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
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  • The impact of Information processing speed on visuospatial memory encoding and retrieval in multiple sclerosis

    Waskowiak, P. T., de Jong, S. R., van Dam, M., Uitdehaag, B. M. J., Schoonheim, M. M., Hulst, H. E., Klein, M. & de Jong, B. A., 2026, In: Journal of clinical and experimental neuropsychology. 48, 4, p. 340-350 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Antiseizure medication in patients with meningioma: a retrospective cohort study on the long-term impact on depression, anxiety and neurocognitive functioning

    Dutch Meningioma Consortium, 1 Aug 2025, In: Journal of Neuro-Oncology. 174, 1, p. 227-234 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    22 Downloads (Pure)
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