Research output per year
Research output per year
Personal profile
Specialisation
Macrophages, regulation of gene expression, enhancer function, atherosclerosis.
Research interests
My research focusses on the transcriptional and epigenetic regulation of macrophages in health and (inflammatory or cardiovascular) disease. In particular, I am interested how gene enhancers function: which transcriptional regulators activate enhancers when macrophages are exposed to disease-associated signals, what genetic variants affect enhancer activity and how does this in turn result in differential gene expression?
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Postdoctoral Fellow, University of California, San Diego (UCSD), Department of Cellular and Molecular Medicine, La Jolla, CA, USA
… → 1 Sept 2021
Keywords
- QR180 Immunology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4
Hoeksema, M. A., Shen, Z., Holtman, I. R., Zheng, A., Spann, N. J., Cobo, I., Gymrek, M. & Glass, C. K., 1 Jun 2021, In: Science advances. 7, 25, abf9808.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Downloads (Pure) -
Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function
Link, V. M., Duttke, S. H., Chun, H. B., Holtman, I. R., Westin, E., Hoeksema, M. A., Abe, Y., Skola, D., Romanoski, C. E., Tao, J., Fonseca, G. J., Troutman, T. D., Spann, N. J., Strid, T., Sakai, M., Yu, M., Hu, R., Fang, R., Metzler, D. & Ren, B. & 1 others, , 14 Jun 2018, In: Cell. 173, 7, p. 1796-1809.e17Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Maggie: Leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function
Shen, Z., Hoeksema, M. A., Ouyang, Z., Benner, C. & Glass, C. K., 2021, In: Bioinformatics. 36, p. I84-I92Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses
Willemsen, L., Chen, H.-J., van Roomen, C. P. A. A., Griffith, G. R., Siebeler, R., Neele, A. E., Kroon, J., Hoeksema, M. A. & de Winther, M. P. J., 10 Feb 2022, In: Frontiers in cardiovascular medicine. 9, p. 829877 829877.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
The regulatory landscape of macrophage interferon signaling in inflammation
Siebeler, R., de Winther, M. P. J. & Hoeksema, M. A., 1 Aug 2023, In: Journal of allergy and clinical immunology. 152, 2, p. 326-337 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access
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SSAR 2024 invited talk
Hoeksema, M. (Speaker)
14 Mar 2024Activity: Talk or presentation › Invited talk › Academic
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ACS - Atherosclerosis and Aortic Disease (Organisational unit)
Hoeksema, M. (Chair)
1 Jan 2023 → …Activity: Membership › Membership of committee › Academic
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AII - Inflammatory diseases (Organisational unit)
Hoeksema, M. (Chair)
1 Jul 2022 → …Activity: Membership › Membership of committee › Academic