Projects per year
Personal profile
Specialisation
Cerebral glucose metabolism, perioperative neurocognitive disorders, circadian rhythm
Research interests
My research interests are centered around three primary pillars: cerebral glucose metabolism, circadian rhythm, and perioperative neurocognitive disorders (PNCD).
In the realm of cerebral glucose metabolism, I investigate alterations in glucose transport and alternative glycolysis pathways post-traumatic brain injury, and the implications of elevated cerebrospinal fluid (CSF) glucose levels and diabetes mellitus on the neurotoxic polyol pathway.
Additionally, my work on circadian rhythms focuses on the effects of surgery and anesthesia on sleep-wake timing (both in children and adults), exploring the physiological and metabolic impacts on postoperative recovery.
My research on perioperative neurocognitive disorders aims to enhance prediction and diagnosis methods for PNCD in older adults undergoing surgery. This includes the prospective comparison of detection methods for perioperative neurocognitive disorders and the exploration of perioperative brain functioning, including the influence of intraoperative hypotension and anesthesia on cognition.
Education/Academic qualification
PhD, Perioperative brain functioning: effects of anesthesia on neurometabolism, cognition and sleep-wake timing, University of Amsterdam
Award Date: 15 Dec 2022
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Projects
- 1 Active
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NVA YIG: NVA Young Investigator Grant 2023
Hermanides, J. (Principal investigator) & van Zuylen, M. (Project Leader)
Nederlandse Ver. voor Anesthesiologie
01/10/2023 → 30/08/2025
Project: Research
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Development of a brief test protocol for assessing cognitive change in the peri-operative period in older adults undergoing elective surgery
Gribnau, A., Geurtsen, G. J., Willems, H. C., Hermanides, J. & van Zuylen, M. L., Jun 2025, In: Anaesthesia. 80, 6, p. 713-715 3 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open AccessFile -
Effects of morning versus afternoon surgery on peri-operative disturbance of sleep–wake timing: An observational study
Meewisse, A. J. G., van Huizen, E. C., Choi, K. F., Kok-de Goede, E. N., Turgman, O., Schenk, J., Hermanides, J. & van Zuylen, M. L., 1 Jan 2025, In: Acta anaesthesiologica Scandinavica. 69, 1, e14543.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
The effects of sleep improving interventions in medical hospital wards: the WEsleep study - A randomized clinical trial
de Gans, C. J., Meewisse, A. J. G., van den Ende, E. S., van Zuylen, M. L., Nanayakkara, P. W. B., Hermanides, J. & Stenvers, D. J., 2025, (E-pub ahead of print) In: European journal of internal medicine.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Cerebral Glucose Metabolism following TBI: Changes in Plasma Glucose, Glucose Transport and Alternative Pathways of Glycolysis—A Translational Narrative Review
Gribnau, A., van Zuylen, M. L., Coles, J. P., Plummer, M. P., Hermanns, H. & Hermanides, J., 1 Mar 2024, In: International journal of molecular sciences. 25, 5, 2513.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile9 Citations (Scopus) -
Comparison between adjusted Montreal Cognitive Assessment and neuropsychological assessment for diagnosing postoperative neurocognitive disorders
Gribnau, A., Geurtsen, G. J., Willems, H. C., Hermanides, J. & van Zuylen, M. L., 1 Nov 2024, In: Anaesthesia. 79, 11, p. 1250-1252 3 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access