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  • 8207
    Citations
1996 …2025

Research activity per year

Personal profile

Research interests

Driven by a strong commitment to innovation in Reproductive Medicine, my ambition is to develop lasting solutions and to provide meaningful  information on effectiveness of therapies and prognostic information —ultimately helping couples achieve their goal: an onging pregnancy and healthy child.

My research focuses on advancing the field of assisted reproductive technologies (ART) such as fertility preservation, and recurrent pregnancy loss. I supervised multiple (inter) national clinical trials in women with breastcancer who opt for oocyte freezing, women with recurrent pregnancy loss, and women undergoing embryotransfer (in IVF/ICSI cycles). 

A major part of my work has brought the clinical problem of recurrent miscarriage to the forefront, both nationally and internationally. I introduced selective karyotyping and contributed critical evidence regarding the effectiveness of commonly used treatments such as progesterone, aspirin, heparin, levothyroxine, helping to refine clinical practice. e.g. Progesterone reduces miscarriage rates in women with three earlier miscarriages and bloodloss in a subsequent pregnancy. 

In the domain of ART, my team and I were among the first to introduce cryo-embryo transfer in the natural cycle, following extensive research demonstrating that it yields pregnancy rates comparable to artificial cycles while reducing complications in pregnancy. 

I am actively involved in large-scale international trials and cohort studies, including the OMEGA cohort, which aims to generate comprehensive insights into the long-term health outcomes of ART for both women and children. We are currently working on research into the addition of Tamoxifen or Letrozole in women with breast cancer who wish to undergo oocyte cryopreservation.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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Collaborations and top research areas from the last five years

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  • Heparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial

    ALIFE2 Block Writing Committee & ALIFE2 Investigators, 1 Jul 2023, In: The Lancet. 402, 10395, p. 54-61 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
    77 Downloads (Pure)
  • Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study)

    Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A. M., van Wely, M., Bloemenkamp, K. W. M., Hoek, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C. J., Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O., Post, M., Papatsonis, D. N. M., Verberg, M. F. G. & Sikkema, J. & 3 others, Mol, B. W., Bisschop, P. H. & Goddijn, M., 2015, In: Contemporary clinical trials. 44, p. 134-138

    Research output: Contribution to journalArticleAcademicpeer-review

  • Sporadic miscarriage: evidence to provide effective care: co author Lancet series

    Coomarasamy, A., Gallos, I. D., Papadopoulou, A., Dhillon-Smith, R. K., Al-Memar, M., Brewin, J., Christiansen, O. B., Stephenson, M. D., Oladapo, O. T., Wijeyaratne, C. N., Small, R., Bennett, P. R., Regan, L., Goddijn, M., Devall, A. J., Bourne, T., Brosens, J. J. & Quenby, S., 1 May 2021, In: The Lancet. 397, 10285, p. 1668-1674 7 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
  • Recurrent miscarriage: evidence to accelerate action: co-author Lancet series

    Coomarasamy, A., Dhillon-Smith, R. K., Papadopoulou, A., Al-Memar, M., Brewin, J., Abrahams, V. M., Maheshwari, A., Christiansen, O. B., Stephenson, M. D., Goddijn, M., Oladapo, O. T., Wijeyaratne, C. N., Bick, D., Shehata, H., Small, R., Bennett, P. R., Regan, L., Rai, R., Bourne, T. & Kaur, R. & 5 others, Pickering, O., Brosens, J. J., Devall, A. J., Gallos, I. D. & Quenby, S., 1 May 2021, In: The Lancet. 397, 10285, p. 1675-1682 8 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
  • A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

    Coomarasamy, A., Williams, H., Truchanowicz, E., Seed, P. T., Small, R., Quenby, S., Gupta, P., Dawood, F., Koot, Y. E. M., Bender Atik, R., Bloemenkamp, K. W. M., Brady, R., Briley, A. L., Cavallaro, R., Cheong, Y. C., Chu, J. J., Eapen, A., Ewies, A., Hoek, A. & Kaaijk, E. M. & 15 others, Koks, C. A. M., Li, T.-C., MacLean, M., Mol, B. W., Moore, J., Ross, J. A., Sharpe, L., Stewart, J., Vaithilingam, N., Farquharson, R. G., Kilby, M. D., Khalaf, Y., Goddijn, M., Regan, L. & Rai, R., 2015, In: New England journal of medicine. 373, 22, p. 2141-2148

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
    22 Downloads (Pure)