Research output per year
Research output per year
Personal profile
Research interests
Research is focused on elucidating the mechanisms underlying cardiac arrhythmias in which the regulation and (mal)function of ion channels, transporters and calcium-handling proteins plays a central role. Insight into arrhythmia mechanisms is achieved by studying electrical activity with the patch-clamp technique in various preparations including: isolated neonatal and adult cardiomyocytes, isolated intracardiac neurons, mammalian cell expression systems etc. Specific projects include:
- The cardiac sodium channel as part of a multi-molecular protein complex
- Differential expression and regulation of the cardiac sodium channels localized to different subcellular micro-domains of the cardiac myocyte
- Biophysical properties of cardiac and neuronal ion channel mutations associated with arrhythmia syndromes
- The role of the cardiac autonomous nervous system in atrial fibrillation: effects of neuropeptides on atrial electrophysiology
- Functional remodeling of intracardiac neurons in heart failure
Specialisation
Cardiac Cellular Electrophysiology
Fingerprint
Dive into the research topics where Marieke Veldkamp is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes
Nasilli, G., De Waal, T. M., Marchal, G. A., Bertoli, G., Veldkamp, M. W., Rothenberg, E., Casini, S. & Remme, C. A., 1 May 2024, In: Cardiovascular research. 120, 7, p. 723-734 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile134 Downloads (Pure) -
Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells
Chen, S., Schumacher, C. A., van Amersfoorth, S. C. M., Fiolet, J. W. T., Baartscheer, A., Veldkamp, M. W., Coronel, R. & Zuurbier, C. J., 2023, In: Frontiers in physiology. 14, 1179131.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure) -
The opioid tramadol blocks the cardiac sodium channel Nav1.5 in HEK293 cells
Jia, L., Veldkamp, M. W., Verkerk, A. O. & Tan, H. L., 1 Sept 2023, In: EP Europace. 25, 9, euad209.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile33 Downloads (Pure) -
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation
Harlaar, N., Dekker, S. O., Zhang, J., Snabel, R. R., Veldkamp, M. W., Verkerk, A. O., Fabres, C. C., Schwach, V., Lerink, L. J. S., Rivaud, M. R., Mulder, A. A., Corver, W. E., Goumans, M. J. T. H., Dobrev, D., Klautz, R. J. M., Schalij, M. J., Veenstra, G. J. C., Passier, R., van Brakel, T. J. & Pijnappels, D. A. & 1 others, , Apr 2022, In: Nature Biomedical Engineering. 6, 4, p. 389-402 14 p.Research output: Contribution to journal › Article › Academic › peer-review
-
Secretome of atrial epicardial adipose tissue facilitates reentrant arrhythmias by myocardial remodeling
Ernault, A. C., Verkerk, A. O., Bayer, J. D., Aras, K., Montañés-Agudo, P., Mohan, R. A., Veldkamp, M., Rivaud, M. R., de Winter, R., Kawasaki, M., van Amersfoorth, S. C. M., Meulendijks, E. R., Driessen, A. H. G., Efimov, I. R., de Groot, J. R. & Coronel, R., Sept 2022, In: Heart rhythm. 19, 9, p. 1461-1470 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure)