Projects per year
Personal profile
Specialisation
Immunotherapy ,
Research interests
My research interests revolve around immunotherapy of NSCLC patients; how can we improve treatment outcome for this patient group. I try to understand why immunotherapy (combinatorial strategies) are effective in some NSCLC patients and not at all in others, and use this knowledge to stratify patients or improve treatment design. In order to achieve this, I make use of multi-color flowcytometry, ELISA, cell-culture, cytokine assays and histology to evaluate blood, tumor-draining lymph nodes and tumor from NSCLC patients.
Specialisation
Immunotherapy, Lymph Node, NSCLC, Biomarkers, Intratumoral
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Fingerprint
Dive into the research topics where Marieke Fransen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
SPACETIME 3 van 7 (AMC): SPatial Analysis of Cancer Evolution in the Tumour Immune MicroEnvironment
Fransen, M. (Principal investigator)
01/08/2024 → 31/07/2029
Project: Research
-
PP 31464 KWF TargetNL 14102: Targeting the local lymphoid tissues to enhance the efficacy of immunotherapy fo non-small cell lung cancer
Fransen, M. (Principal investigator)
01/01/2022 → 31/12/2025
Project: Research
-
KWF 14466 M. Fransen: PP 2011444 KWF 14466 MF
Fransen, M. (Principal investigator)
01/01/2025 → 31/01/2025
Project: Research
-
PP 31539 KWF 14466 M. Fransen: Spontaneous tumor-specific antibodies as predictive biomarkers and enhancers of therapy efficacy in patients with non-small cell lung cancer te financieren
Fransen, M. (Principal investigator)
01/04/2023 → 31/01/2025
Project: Research
-
RadioLN: CCA 20-36 M. Fransen
Fransen, M. (Principal investigator)
Stichting Cancer Center Amsterdam
15/02/2021 → 28/02/2022
Project: Research
-
Comparison of the tumor microenvironments of squamous cell carcinoma at different anatomical locations within the upper aerodigestive tract in relation to response to ICI therapy
van Duijvenvoorde, M., Derks, S., Bahce, I., Leemans, C. R., van de Ven, R. & Fransen, M. F., 2022, In: Clinical & translational immunology. 11, 1, p. e1363 e1363.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Immunological Responses to Cancer Therapy
Fransen, M. F., 1 Jul 2022, In: International journal of molecular sciences. 23, 13, 6989.Research output: Contribution to journal › Editorial › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy
Fransen, M. F., Schoonderwoerd, M., Knopf, P., Camps, M. G., Hawinkels, L. J., Kneilling, M., van Hall, T. & Ossendorp, F., 2018, In: JCI insight. 3, 23Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy
Kleinovink, J. W., Marijt, K. A., Schoonderwoerd, M. J. A., van Hall, T., Ossendorp, F. & Fransen, M. F., 2017, In: Oncoimmunology. 6, 4, e1294299.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy
Schoonderwoerd, M. J. A., Koops, M. F. M., Angela, R. A., Koolmoes, B., Toitou, M., Paauwe, M., Barnhoorn, M. C., Liu, Y., Sier, C. F. M., Hardwick, J. C. H., Nixon, A. B., Theuer, C. P., Fransen, M. F. & Hawinkels, L. J. A. C., 15 Jul 2020, In: Clinical cancer research. 26, 14, p. 3831-3842 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Activities
- 1 organising
-
Dutch Tumor Immunology Meeting
Fransen, M. (Organiser)
1 Jan 2018 → 1 Jan 4000Activity: Participating in or organising an event › organising