Projects per year
Personal profile
Research interests
The focus of our research is to understand the molecular mechanisms that drive commitment of the hematopoietic stem cell (HSC) to a megakaryocytic-erythroid progenitor (MEP), and that stimulate subsequent expansion and differentiation of the erythroid and megakaryocytic compartments.
The aim of our research is to restore healthy numbers of erythrocytes and platelets in patients with congenital anemia or thrombocytopenia. Thereto we study (i) the requirements for large scale production of erythrocytes and platelets to generate personalized transfusion products, and (ii) in mechanisms that are affected in congenital anemia or thrombocytopenia with the aim to find other solutions than erythrocyte or platelet transfusion.
specialisation
Hematopoiesis, erythropoiesis
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The European Diamond-Blackfan Anemia Consortium Global Bridges Meeting
von Lindern, M. (Principal investigator)
01/06/2019 → …
Project: Research
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Selective mRNA translation controls erythropoiesis; Regulation and function of the RNA-binding protein Csde1
Dann, S. L. S. L. (Principal investigator), von Lindern, M. (Principal investigator), Ikeda, T. T. (Principal investigator), Imazawa, T. T. (CoPI), Nakanishi, Y. Y. (CoPI), Nakamura, H. H. (CoPI) & Kurose, M. M. (CoPI)
Landsteiner Foundation for Blood Transfusion Research
01/01/2010 → 31/12/2014
Project: Research
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Christensen Fund award
von Lindern, M. (Principal investigator), Ishikawa, K. K. (Principal investigator) & Services, C. P. (Staff)
Landsteiner Foundation for Blood Transfusion Research
02/02/2009 → 31/12/2015
Project: Research
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FOAM
Zorn, T. T. (Principal investigator), Van Der Reijden, B. B. (Principal investigator), von Lindern, M. (CoPI), Ohya, S. S. (Principal investigator), Kito, H. H. (CoPI), Cox, M. M. (Principal investigator) & Dreher, B. B. (Principal investigator)
Landsteiner Foundation for Blood Transfusion Research
01/01/2000 → 31/12/2018
Project: Research
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Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Horos, R., Ijspeert, H., Pospisilova, D., Sendtner, R., Andrieu-Soler, C., Taskesen, E., Nieradka, A., Cmejla, R., Sendtner, M., Touw, I. P. & von Lindern, M., 2012, In: Blood. 119, 1, p. 262-272Research output: Contribution to journal › Article › Academic › peer-review
148 Citations (Scopus) -
Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia
Horos, R. & von Lindern, M., 2012, In: British journal of haematology. 159, 5, p. 514-527Research output: Contribution to journal › Review article › Academic › peer-review
54 Citations (Scopus) -
Assessing the translational landscape of myogenic differentiation by ribosome profiling
de Klerk, E., Fokkema, I. F. A. C., Thiadens, K. A. M. H., Goeman, J. J., Palmblad, M., den Dunnen, J. T., von Lindern, M. & 't Hoen, P. A. C., 2015, In: Nucleic acids research. 43, 9, p. 4408-4428Research output: Contribution to journal › Article › Academic › peer-review
45 Citations (Scopus) -
A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Paolini, N. A., Attwood, M., Sondalle, S. B., Vieira, C. M. D. S., van Adrichem, A. M., di Summa, F. M., O'Donohue, M.-F., Gleizes, P.-E., Rachuri, S., Briggs, J. W., Fischer, R., Ratcliffe, P. J., Wlodarski, M. W., Houtkooper, R. H., von Lindern, M., Kuijpers, T. W., Dinman, J. D., Baserga, S. J., Cockman, M. E. & MacInnes, A. W., 2017, In: American journal of human genetics. 100, 3, p. 506-522Research output: Contribution to journal › Article › Academic › peer-review
67 Citations (Scopus) -
Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment
Nieradka, A., Ufer, C., Thiadens, K., Grech, G., Horos, R., van Coevorden-Hameete, M., van den Akker, E., Sofi, S., Kuhn, H. & von Lindern, M., 2014, In: PLoS ONE. 9, 9, p. e104631Research output: Contribution to journal › Article › Academic › peer-review
21 Citations (Scopus)