Projects per year
Personal profile
Research interests
- Cancer stem cells
- Colorectal cancer
- Cancer subtypes
- Tumor evolution
specialisation
Cancer research
External positions
Vice President, Head of Discovery Oncology, Genentech Inc.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Using Molecular Subtypes to predict anti-EGFR Responses in metastatic Colorectal Cancer
Vermeulen, L. (Principal investigator)
01/01/2016 → …
Project: Research
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Colon cancer heterogeneity: stem cells, signals and subtypes
Vermeulen, L. (Principal investigator)
European Molecular Biology Organization
01/01/2018 → 31/12/2022
Project: Research
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Developing Rationale Colon Cancer Prevention Strategies by Targeting Oncogenic Stem Cells Dynamics
Vermeulen, L. (Principal investigator)
01/08/2014 → 31/07/2017
Project: Research
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Wnt-gereguleerde lange niet-coderende RNA’s als de achilleshiel van colorectale kanker
Cornejo Parriego, R. R. (Principal investigator), Leveille, N. (Principal investigator), Vermeulen, L. (CoPI), Murre, C. C. (CoPI) & Ltd, S.-A. A. P. (Staff)
01/01/2011 → 28/02/2018
Project: Research
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Lumina Foundation Award
Roffman, J. L. (Principal investigator) & Vermeulen, L. (Principal investigator)
01/01/2007 → 30/04/2020
Project: Research
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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
de Sousa E Melo, F., Wang, X., Jansen, M., Fessler, E., Trinh, A., de Rooij, L. P. M. H., de Jong, J. H., de Boer, O. J., van Leersum, R., Bijlsma, M. F., Rodermond, H., van der Heijden, M., van Noesel, C. J. M., Tuynman, J. B., Dekker, E., Markowetz, F., Medema, J. P. & Vermeulen, L., 2013, In: Nature medicine. 19, 5, p. 614-618Research output: Contribution to journal › Article › Academic › peer-review
622 Citations (Scopus) -
The consensus molecular subtypes of colorectal cancer
Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., Bot, B. M., Morris, J. S., Simon, I. M., Gerster, S., Fessler, E., de Sousa E Melo, F., Missiaglia, E., Ramay, H., Barras, D. & Homicsko, K. & 20 others, , 2015, In: Nature medicine. 21, 11, p. 1350-1356Research output: Contribution to journal › Article › Academic › peer-review
3657 Citations (Scopus) -
Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation
Vermeulen, L., Morrissey, E., van der Heijden, M., Nicholson, A. M., Sottoriva, A., Buczacki, S., Kemp, R., Tavaré, S. & Winton, D. J., 2013, In: Science. 342, 6161, p. 995-998Research output: Contribution to journal › Article › Academic › peer-review
329 Citations (Scopus) -
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
Medema, J. P. & Vermeulen, L., 2011, In: Nature. 474, 7351, p. 318-326Research output: Contribution to journal › Review article › Academic › peer-review
401 Citations (Scopus) -
From tumour heterogeneity to advances in precision treatment of colorectal cancer
Punt, C. J. A., Koopman, M. & Vermeulen, L., 2017, In: Nature reviews. Clinical oncology. 14, 4, p. 235-246Research output: Contribution to journal › Review article › Academic › peer-review
486 Citations (Scopus)
Datasets
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Additional file 8 of Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Buikhuisen, J. Y. (Creator), Gomez Barila, P. M. (Creator), Cameron, K. (Creator), Suijkerbuijk, S. J. E. (Creator), Lieftink, C. (Creator), di Franco, S. (Creator), Krotenberg Garcia, A. (Creator), Uceda Castro, R. (Creator), Lenos, K. J. (Creator), Nijman, L. E. (Creator), Torang, A. (Creator), Longobardi, C. (Creator), de Jong, J. H. (Creator), Dekker, D. (Creator), Stassi, G. (Creator), Vermeulen, L. (Creator), Beijersbergen, R. L. (Creator), van Rheenen, J. (Creator), Huveneers, S. (Creator) & Medema, J. P. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22626329.v1, https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Subtype-specific_kinase_dependency_regulates_growth_and_metastasis_of_poor-prognosis_mesenchymal_colorectal_cancer/22626329/1
Dataset
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Additional file 9 of Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Buikhuisen, J. Y. (Creator), Gomez Barila, P. M. (Creator), Cameron, K. (Creator), Suijkerbuijk, S. J. E. (Creator), Lieftink, C. (Creator), di Franco, S. (Creator), Krotenberg Garcia, A. (Creator), Uceda Castro, R. (Creator), Lenos, K. J. (Creator), Nijman, L. E. (Creator), Torang, A. (Creator), Longobardi, C. (Creator), de Jong, J. H. (Creator), Dekker, D. (Creator), Stassi, G. (Creator), Vermeulen, L. (Creator), Beijersbergen, R. L. (Creator), van Rheenen, J. (Creator), Huveneers, S. (Creator) & Medema, J. P. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22626332, https://springernature.figshare.com/articles/dataset/Additional_file_9_of_Subtype-specific_kinase_dependency_regulates_growth_and_metastasis_of_poor-prognosis_mesenchymal_colorectal_cancer/22626332
Dataset
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Additional file 9 of Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Buikhuisen, J. Y. (Creator), Gomez Barila, P. M. (Creator), Cameron, K. (Creator), Suijkerbuijk, S. J. E. (Creator), Lieftink, C. (Creator), di Franco, S. (Creator), Krotenberg Garcia, A. (Creator), Uceda Castro, R. (Creator), Lenos, K. J. (Creator), Nijman, L. E. (Creator), Torang, A. (Creator), Longobardi, C. (Creator), de Jong, J. H. (Creator), Dekker, D. (Creator), Stassi, G. (Creator), Vermeulen, L. (Creator), Beijersbergen, R. L. (Creator), van Rheenen, J. (Creator), Huveneers, S. (Creator) & Medema, J. P. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22626332.v1, https://springernature.figshare.com/articles/dataset/Additional_file_9_of_Subtype-specific_kinase_dependency_regulates_growth_and_metastasis_of_poor-prognosis_mesenchymal_colorectal_cancer/22626332/1
Dataset
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Additional file 8 of Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
Buikhuisen, J. Y. (Creator), Gomez Barila, P. M. (Creator), Cameron, K. (Creator), Suijkerbuijk, S. J. E. (Creator), Lieftink, C. (Creator), di Franco, S. (Creator), Krotenberg Garcia, A. (Creator), Uceda Castro, R. (Creator), Lenos, K. J. (Creator), Nijman, L. E. (Creator), Torang, A. (Creator), Longobardi, C. (Creator), de Jong, J. H. (Creator), Dekker, D. (Creator), Stassi, G. (Creator), Vermeulen, L. (Creator), Beijersbergen, R. L. (Creator), van Rheenen, J. (Creator), Huveneers, S. (Creator) & Medema, J. P. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.22626329, https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Subtype-specific_kinase_dependency_regulates_growth_and_metastasis_of_poor-prognosis_mesenchymal_colorectal_cancer/22626329
Dataset
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Additional file 2 of Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development
Adam, R. S. (Creator), van Neerven, S. M. (Contributor), Pleguezuelos-Manzano, C. (Creator), Simmini, S. (Creator), Léveillé, N. (Creator), de Groot, N. E. (Contributor), Holding, A. N. (Creator), Markowetz, F. (Creator) & Vermeulen, L. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.13331696.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Intestinal_region-specific_Wnt_signalling_profiles_reveal_interrelation_between_cell_identity_and_oncogenic_pathway_activity_in_cancer_development/13331696/1
Dataset