Personal profile
Research interests
To ultimately cure or prevent rheumatoid arthritis, it is critical to understand the earliest changes in the immune system that cause RA. Starting from a genome-wide expression profiling approach, this research will delineate the role of stromal cells in bone marrow, lymph node and synovial tissue in arthritis development. Results from these studies will provide innovative drug targets for preventive intervention in pre-clinical RA and identify the immunological processes that initiate RA and possibly other related chronic inflammatory diseases. In addition, molecular profiling of biomaterials is used to identify biomarkers for diagnosis, prognosis and treatment response.
Specialisation
Genomics; Immunology; Translational Research; Celbiology; Rheumatology; Stromal cells; Autoimmunity; Tolerance
Related documents
Education/Academic qualification
PhD, Heterogenomics of autoimmunity; Towards personalized medicine, VU University: -
2004 → 2008
Award Date: 1 Oct 2009
Keywords
- Q Science (General)
- R Medicine (General)
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Collaborations and top research areas from the last five years
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Synovial gene signatures associated with the development of rheumatoid arthritis in at risk individuals: A prospective study
de Jong, T. A., de Hair, M. J. H., van de Sande, M. G. H., Semmelink, J. F., Choi, I. Y., Gerlag, D. M., Tak, P. P. & van Baarsen, L. G. M., 1 Dec 2022, In: Journal of autoimmunity. 133, 102923.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis
van Baarsen, L. G. M., de Hair, M. J. H., Ramwadhdoebe, T. H., Zijlstra, I. J. A. J., Maas, M., Gerlag, D. M. & Tak, P. P., 2013, In: Annals of the rheumatic diseases. 72, 8, p. 1420-1424Research output: Contribution to journal › Article › Academic › peer-review
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EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis
Gerlag, D. M., Raza, K., van Baarsen, L. G. M., Brouwer, E., Buckley, C. D., Burmester, G. R., Gabay, C., Catrina, A. I., Cope, A. P., Cornelis, F., Dahlqvist, S. R., Emery, P., Eyre, S., Finckh, A., Gay, S., Hazes, J. M., van der Helm-van Mil, A., Huizinga, T. W. J., Klareskog, L. & Kvien, T. K. & 11 others, , 2012, In: Annals of the rheumatic diseases. 71, 5, p. 638-641Research output: Contribution to journal › Review article › Academic › peer-review
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Altered lipid metabolism in synovial fibroblasts of individuals at risk of developing rheumatoid arthritis
de Jong, T. A., Semmelink, J. F., Denis, S. W., van de Sande, M. G. H., Houtkooper, R. H. L. & van Baarsen, L. G. M., 1 Jan 2023, In: Journal of autoimmunity. 134, 102974.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Downloads (Pure) -
Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis
de Jong, T. A., Semmelink, H. F., Denis, S. W., Bolt, J. W., Maas, M., van de Sande, M. G. H., Houtkooper, R. H. L., van Baarsen, L. G. M. & Semmelink, J. F., 1 Jan 2023, In: Cells. 12, 1, 1.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure)