Personal profile
Research interests
Research interests include statstical modeling, causal inference, and mediation analysis.
Specialisation
My research focuses on causal inference for intensive care data. In this field, we have methodological questions that are specific to the ICU: how can we account for informative censoring and competing events (patients die or are discharged from the intensive care unit)? How to model complex underlying biological mechanisms? Can we deal with heterogeneous patient populations? And what about the fact that interventions probably do not have one stable effect but their effectiveness varies over time?
Education/Academic qualification
Master, Methodology & Statistics, Utrecht University, Utrecht, Netherlands
Award Date: 1 Jun 2023
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Collaborations and top research areas from the last five years
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Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury
Kramer, L., Calfee, C. S., Mcauley, D. F., O'Kane, C., Aman, J., Duijvelaar, E., Giamarellos-Bourboulis, E. J., Antonakos, N., Heymans, M. W. & Bos, L. D. J., 28 Apr 2026, (E-pub ahead of print) In: American journal of respiratory and critical care medicine.Research output: Contribution to journal › Article › Academic › peer-review
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Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill
Platform of Randomized Adaptive Clinical Trials in Critical Illness (PRACTICAL) investigators, Jun 2025, In: The Lancet. Respiratory medicine. 13, 6, p. 556-568 13 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile150 Downloads (Pure) -
Need for cognition, academic self-efficacy and parental education predict the intention to go to college—evidence from a multigroup study
Kramer, L., Lüdtke, S. & Freund, P. A., 2025, In: Frontiers in psychology. 16, 1487038.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure
MARS consortium, Dec 2025, In: Critical care (London, England). 29, 1, p. 198 198.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure)