Projects per year
Personal profile
Specialisation
MRI, pathology, neurodegeneration
Research interests
My main research aim is to translate post mortem MRI signatures of neuropathology and neurodegeneration to the clinical setting in order to facilitate a better interpretation of MRI datasets, contributing to a better diagnosis, prognosis and patient stratification.
For this, we set up a standardized pipeline including Alzheimer’s disease and other dementia, Parkinson’s disease, and non-neurological control donors, all undergoing the same 3T in-situ MRI and autopsy protocol with subsequent pathological assessment.
With this approach, my research line is threefold: studying the influence of pathological and neuronal markers on (i) cortical alterations, (ii) specific nuclei and their projections, and (ii) the integrating and segregating brain network.
Related documents
Education/Academic qualification
PhD, Visualizing and Characterizing Tissue Abnormalities in Multiple Sclerosis, VUmc, Amsterdam, Netherlands
Award Date: 17 Feb 2016
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Collaborations and top research areas from the last five years
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Projects
- 2 Active
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Impact of Interneurons on Brain Networks in Alzheimer's Disease
Jonkman, L. (Principal investigator)
01/01/2022 → …
Project: Research
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Impact of (p-)Tau and amyloid-ß on brain networks in Alzheimer patients
Jonkman, L. (Principal investigator)
01/01/2018 → …
Project: Research
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Structural (dys)connectivity associates with cholinergic cell density in Alzheimer's disease
Lin, C. P., Frigerio, I., Boon, B. D. C., Zhou, Z., Rozemuller, A. J. M., Bouwman, F. H., Schoonheim, M. M., van de Berg, W. D. J. & Jonkman, L. E., 1 Aug 2022, In: Brain. 145, 8, p. 2869-2881 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access18 Citations (Scopus) -
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson?s disease dementia
Frigerio, I., Laansma, M. A., Lin, C.-P., Hermans, E. J. M., Bouwman, M. M. A., Bol, J. G. J. M., Galis-de Graaf, Y., Hepp, D. H., Rozemuller, A. J. M., Barkhof, F., van de Berg, W. D. J. & Jonkman, L. E., 1 Dec 2023, In: Translational Neurodegeneration. 12, 1, 3.Research output: Contribution to journal › Article › Academic › peer-review
Open Access15 Citations (Scopus) -
Diffuse Amyloid-β relates to lower structural degree and higher local efficiency in the posterior cingulate cortex: a post-mortem MRI and histology study.
Jonkman, L., Steenwijk, M., Galis-de Graaf, Y., Rozemuller, A., Geurts, J., Barkhof, F. & van de Berg, W., 2020, (Accepted/In press) In: Neurology.Research output: Contribution to journal › Article › Academic › peer-review
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Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease
Lin, C.-P., Knoop, L. E. J., Frigerio, I., Bol, J. G. J. M., Rozemuller, A. J. M., Berendse, H. W., Pouwels, P. J. W., van de Berg, W. D. J. & Jonkman, L. E., Sept 2023, In: Movement disorders. 38, 9, p. 1655-1667 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access5 Citations (Scopus) -
Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls
Jonkman, L. E., Graaf, Y.G.-D., Bulk, M., Kaaij, E., Pouwels, P. J. W., Barkhof, F., Rozemuller, A. J. M., van der Weerd, L., Geurts, J. J. G. & van de Berg, W. D. J., 1 Jan 2019, In: NeuroImage: Clinical. 22, 101698.Research output: Contribution to journal › Article › Academic › peer-review
Open Access26 Citations (Scopus)
Activities
- 1 Membership of board
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Anatomy and Neurosciences (Organisational unit)
van de Berg, W. (Chair), Jonkman, L. (Member) & Geurts, J. (Member)
1 Jan 2014 → …Activity: Membership › Membership of board › Academic
Prizes
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A picture is worth a thousand words: telling the tale of the Parkinson brain with correlative postmortem MRI and microscopy.
van de Berg, W. (Recipient), Jonkman, L. (Recipient), Berendse, H. (Recipient) & van der Werf, Y. (Recipient), 2019
Prize: Honorary award › Academic