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Laura Han

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Laura Han

DR.

 https://orcid.org/0000-0001-9647-3723
  • 1984
    Citations
20152026

Research activity per year

Personal profile

Research interests

My research is focused on the complex links between major depression and age-related biology. Using a wide range of neuroscientific methods, my work aims to:

  • identify determinants of age-related biology and mental ill-health,
  • study their longitudinal dynamics, and
  • evaluate prognostic potential and reversibility following treatment.

With a background in neuroscience and specific training in biomarkers of mental ill-health, I completed my PhD in Psychiatry awarded with a cum laude distinction. My thesis revealed that adults with depression appear biologically older than non-depressed peers, and I have extended this work to early-intervention in young people aged 15-25 years (NWO Rubicon). I am currently aggregating high-quality diverse datasets from around the world to assess the consistency of findings across cohorts with the aim to promote the clinical application of age-related biomarkers in major depression (NWO Veni).

Specialisation

Biological aging • Brain age • Epigenetics • Depression & Anxiety • Neuroimaging • Predictive modeling • Longitudinal Cohorts • Personalized Psychiatry • Biomarkers for treatment • ENIGMA Consortium

Related documents

Education/Academic qualification

Master, MSc Brain and Cognitive Sciences (cum laude)

Award Date: 24 Jul 2015

BSc Psychobiology

Award Date: 31 Aug 2012

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  • Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group: results from the ENIGMA major depressive disorder working group

    Han, L. K. M., Dinga, R., Hahn, T., Ching, C. R. K., Eyler, L. T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B. T., Berger, K., Brak, I., Filho, G. B., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C. G., Dima, D. & Duran, F. L. S. & 126 others, Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C. H. Y., Godlewska, B. R., Gotlib, I. H., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Ho, T. C., Hosten, N., Jansen, A., Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F. P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K. L., Medland, S. E., Mueller, B. A., Mwangi, B., Osipov, E., Portella, M. J., Pozzi, E., Reneman, L., Repple, J., Rosa, P. G. P., Sacchet, M. D., Sämann, P. G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J. C., Sommer, J., Stein, D. J., Steinsträter, O., Strike, L. T., Thomopoulos, S. I., van Tol, M.-J., Veer, I. M., Vermeiren, R. R. J. M., Walter, H., van der Wee, N. J. A., van der Werff, S. J. A., Whalley, H., Winter, N. R., Wittfeld, K., Wright, M. J., Wu, M.-J., Völzke, H., Yang, T. T., Zannias, V., de Zubicaray, G. I., Zunta-Soares, G. B., Abé, C., Alda, M., Andreassen, O. A., Bøen, E., Bonnin, C. M., Canales-Rodriguez, E. J., Cannon, D., Caseras, X., Chaim-Avancini, T. M., Elvsåshagen, T., Favre, P., Foley, S. F., Fullerton, J. M., Goikolea, J. M., Haarman, B. C. M., Hajek, T., Henry, C., Houenou, J., Howells, F. M., Ingvar, M., Kuplicki, R., Lafer, B., Landén, M., Machado-Vieira, R., Malt, U. F., McDonald, C., Mitchell, P. B., Nabulsi, L., Otaduy, M. C. G., Overs, B. J., Polosan, M., Pomarol-Clotet, E., Radua, J., Rive, M. M., Roberts, G., Ruhe, H. G., Salvador, R., Sarró, S., Satterthwaite, T. D., Savitz, J., Schene, A. H., Schofield, P. R., Serpa, M. H., Sim, K., Soeiro-de-Souza, M. G., Sutherland, A. N., Temmingh, H. S., Timmons, G. M., Uhlmann, A., Vieta, E., Wolf, D. H., Zanetti, M. V., Jahanshad, N., Thompson, P. M., Veltman, D. J., Penninx, B. W. J. H., Marquand, A. F., Cole, J. H. & Schmaal, L., Sept 2021, In: Molecular psychiatry. 26, 9, p. 5124-5139 16 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    46 Downloads (Pure)

  • Lagged effects of childhood depressive symptoms on adult epigenetic aging

    Han, L. K. M., Aghajani, M., Penninx, B. W. J. H., Copeland, W. E., Aberg, K. A. & van den Oord, E. J. C. G., 2024, In: Psychological medicine. 54, 12, p. 3398-3406 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    47 Downloads (Pure)

  • Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine

    Han, L. K. M., Dehestani, N., Suo, C., Daglas-Georgiou, R., Hasty, M., Kader, L., Murphy, B. P., Pantelis, C., Yücel, M., Berk, M. & Schmaal, L., 1 Jun 2025, In: European neuropsychopharmacology. 95, p. 40-48 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    34 Downloads (Pure)

  • The researcher's guide to selecting biomarkers in mental health studies

    Verhoeven, J. E., Wolkowitz, O. M., Barr Satz, I., Conklin, Q., Lamers, F., Lavebratt, C., Lin, J., Lindqvist, D., Mayer, S. E., Melas, P. A., Milaneschi, Y., Picard, M., Rampersaud, R., Rasgon, N., Ridout, K., Söderberg Veibäck, G., Trumpff, C., Tyrka, A. R., Watson, K. & Wu, G. W. Y. & 4 others, Yang, R., Zannas, A. S., Han, L. K. M. & Månsson, K. N. T., 1 Oct 2024, In: BioEssays. 46, 10, 2300246.

    Research output: Contribution to journal › Review article › Academic › peer-review

    Open Access
    File
    18 Downloads (Pure)

  • An integrative study of five biological clocks in somatic and mental health

    Jansen, R., Han, L. K. M., Verhoeven, J. E., Aberg, K. A., van den Oord, E. C. G. J., Milaneschi, Y. & Penninx, B. W. J. H., Feb 2021, In: eLife. 10, p. 1-20 20 p., e59479.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    10 Downloads (Pure)
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