Projects per year
Personal profile
Research interests
Designing hepatitis C virus (HCV) E1E2 glycoproteins for structural studies and vaccine studies.
Producing and designing novel HIV-1 envelope glycoproteins.
Specialisation
hepatitis C virus (HCV), HIV-1, envelope glycoproteins, vaccines, nanoparticles
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Dive into the research topics where Kwinten Sliepen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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TKI Call 2024 - VHHV: high-affinity VHH-antibodies for a Hepatitis C Virus (HCV) lateral-flow E1E2-antigen test
Schinkel, J. (Principal investigator) & Sliepen, K. (Project Member)
01/07/2024 → 30/06/2027
Project: Research
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Open Philantropy JS/KS/RS/: Native-like E1E2 glycoprotein immunogens to induce hepatitis C virus broadly neutralizing antibodies
Sanders, R. (Principal investigator) & Sliepen, K. (Project Leader)
19/12/2023 → 01/01/2027
Project: Research
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Vidi Janke Schinkel: Finding hepatitis C virus Achilles' heel: understanding protective immunity to guide vaccine design
Schinkel, J. (Principal investigator) & Sliepen, K. (Project Member)
01/11/2019 → 12/02/2027
Project: Research
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Vici NWO: Training B cells to generate broadly neutralizing HIV antibodies
Sanders, R. (Principal investigator) & Sliepen, K. (Project Member)
01/09/2018 → 31/08/2025
Project: Research
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TKI Call 2022 - SPIKE V: Spike virosome SARS-CoV-2 vaccine to induce durable and broad immunity
Sanders, R. (Principal investigator), Sliepen, K. (Project Member) & van Gils, M. (Project Member)
15/10/2021 → 14/10/2023
Project: Research
Research output
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Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein
Radić, L., Offersgaard, A., Kadavá, T., Zon, I., Capella-Pujol, J., Mulder, F., Koekkoek, S., Spek, V., Chumbe, A., Bukh, J., van Gils, M. J., Sanders, R. W., Yin, V. C., Heck, A. J. R., Gottwein, J. M., Sliepen, K. & Schinkel, J., 15 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 15, e2420402122.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
A panel of hepatitis C virus glycoproteins for the characterization of antibody responses using antibodies with diverse recognition and neutralization patterns
Chumbe, A., Grobben, M., Capella-Pujol, J., Koekkoek, S. M., Zon, I., Slamanig, S., Merat, S. J., Beaumont, T., Sliepen, K., Schinkel, J. & van Gils, M. J., 1 Mar 2024, In: Virus research. 341, 199308.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
A spike virosome vaccine induces pan-sarbecovirus antibody responses in mice
Brinkkemper, M., Poniman, M., Siteur-van Rijnstra, E., Iddouch, W. A., Bijl, T. P. L., Guerra, D., Tejjani, K., Grobben, M., Bhoelan, F., Bemelman, D., Kempers, R., van Gils, M. J., Sliepen, K., Stegmann, T., van der Velden, Y. U. & Sanders, R. W., 17 May 2024, In: iScience. 27, 5, 109719.Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain
Guerra, D., Radić, L., Brinkkemper, M., Poniman, M., van der Maas, L., Torres, J. L., Ward, A. B., Sliepen, K., Schinkel, J., Sanders, R. W., van Gils, M. J. & Beaumont, T., 2024, In: Human vaccines & immunotherapeutics. 20, 1, 2388344.Research output: Contribution to journal › Article › Academic › peer-review
Open Access1 Citation (Scopus) -
Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes
Brinkkemper, M., Kerster, G., Brouwer, P. J. M., Tran, A. S., Torres, J. L., Ettema, R. A., Nijhuis, H., Allen, J. D., Zhu, W., Gao, H., Lee, W.-H., Bijl, T. P. L., Snitselaar, J. L., Burger, J. A., Bontjer, I., Olijhoek, W., Ravichandran, R., van Breemen, M. J., del Moral-Sánchez, I. & Derking, R. & 9 others, , 1 Oct 2024, In: PLoS pathogens. 20, 10 October, e1012558.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Datasets
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BG505 SOSIP-I53-50NP
Brouwer, P. J. M. (Contributor), Antanasijevic, A. (Contributor), Berndsen, Z. (Contributor), Yasmeen, A. (Contributor), Fiala, B. (Contributor), Bijl, T. P. L. (Contributor), Bontjer, I. (Contributor), Bale, J. B. (Contributor), Sheffler, W. (Contributor), Allen, J. D. (Contributor), Schorcht, A. (Contributor), Burger, J. A. (Contributor), Camacho, M. (Contributor), Ellis, D. (Contributor), Cottrell, C. A. (Contributor), Behrens, A.-J. (Contributor), Catalano, M. (Contributor), del Moral-Sánchez, I. (Contributor), Ketas, T. J. (Contributor), LaBranche, C. (Contributor), van Gils, M. J. (Contributor), Sliepen, K. (Contributor), Stewart, L. J. (Contributor), Crispin, M. (Contributor), Montefiori, D. C. (Contributor), Baker, D. (Contributor), Moore, J. P. (Contributor), Klasse, P. J. (Contributor), Ward, A. B. (Contributor), King, N. P. (Contributor) & Sanders, R. W. (Contributor), Protein Data Bank (PDB), 19 Jun 2019
DOI: 10.2210/pdb6P6F/pdb, https://www.wwpdb.org/pdb?id=pdb_00006p6f
Dataset