Projects per year
Personal profile
Research interests
Innate and adaptive immune responses in vector-borne diseases and Lyme borreliosis in particular.
Ticks require a bloodmeal to reproduce, during which they not only transmit Borrelia burgdorferi - the causative agent of Lyme borreliosis -, but also introduce physiologically active proteins into the host skin. These proteins inhibit blood coagulation and suppress local host immune responses, which facilitates both tick feeding as well as B. burgdorferi infection. Identification of the molecular mechanisms involved in immunosuppression induced by tick salivary proteins contributes to the understanding of the pathogenesis of Lyme borreliosis and could lead to the development of novel anti-inflammatory or immunosuppressive agents. In addition, interfering with tick-host-pathogen interactions, for example by an anti-tick vaccin based on specific tick (salivary) proteins, could prevent transmission of B. burgdorferi from the tick to the host.
Specialisation
Internal Medicine - Infectious Diseases
Founder of the Amsterdam UMC Multidisciplinary Lyme borreliosis Center
Research interests
Director of the Amsterdam institute for Immunology & Infectious diseases
Education/Academic qualification
PhD, Tick-host-pathogen interactions in Lyme borreliosis
Award Date: 13 Mar 2009
External positions
Member of the board of the Dutch Lyme borreliosis center
Program leader Infectious Diseases of the Amsterdam Infection & Immunity Institute
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Vaccinatie tegen Bm86 homologen in konijnen heeft geen effect op Ixodes ricinus voeding of ovipositie
Hovius, J. (Principal investigator)
11/08/2015 → 30/08/2016
Project: Research
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A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
Schuijt, T. J., Coumou, J., Narasimhan, S., Dai, J., Deponte, K., Wouters, D., Brouwer, M., Oei, A., Roelofs, J. J. T. H., van Dam, A. P., van der Poll, T., van't Veer, C., Hovius, J. W. & Fikrig, E., 2011, In: Cell host & microbe. 10, 2, p. 136-146Research output: Contribution to journal › Article › Academic › peer-review
144 Citations (Scopus) -
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe
Hovius, J. W. R., de Wever, B., Sohne, M., Brouwer, M. C., Coumou, J., Wagemakers, A., Oei, A., Knol, H., Narasimhan, S., Hodiamont, C. J., Jahfari, S., Pals, S. T., Horlings, H. M., Fikrig, E., Sprong, H. & van Oers, M. H. J., 2013, In: Lancet. 382, 9892, p. 658Research output: Contribution to journal › Editorial › Academic › peer-review
229 Citations (Scopus) -
Ticking the right boxes: Classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands
Coumou, J., Herkes, E. A., Brouwer, M. C., van de Beek, D., Tas, S. W., Casteelen, G., van Vugt, M., Starink, M. V., de Vries, H. J. C., de Wever, B., Spanjaard, L. & Hovius, J. W. R., 1 Apr 2015, In: Clinical microbiology and infection. 21, 4, p. 368.e11-368.e20Research output: Contribution to journal › Article › Academic › peer-review
Open Access51 Citations (Scopus) -
Probability of Spirochete Borrelia miyamotoi Transmission from Ticks to Humans
Sarksyan, D. S., Platonov, A. E., Karan, L. S., Shipulin, G. A., Sprong, H. & Hovius, J. W. R., 2015, In: Emerging infectious diseases. 21, 12, p. 2273-2274Research output: Contribution to journal › Comment/Letter to the editor › Academic
17 Citations (Scopus) -
Andere tekenbeetziekten
Hoornstra, D., Sprong, H. & Hovius, J. W., 1 Jul 2020, In: Nederlands tijdschrift voor geneeskunde. 164, 28, D4603.Research output: Contribution to journal › Article › Professional
1 Citation (Scopus)
Impacts
Datasets
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Additional file 1 of Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens
Azagi, T. (Creator), Harms, M. (Creator), Swart, A. (Creator), Fonville, M. (Creator), Hoornstra, D. (Creator), Mughini-Gras, L. (Creator), Hovius, J. W. (Creator), Sprong, H. (Creator) & van den Wijngaard, C. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.19386688, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Self-reported_symptoms_and_health_complaints_associated_with_exposure_to_Ixodes_ricinus-borne_pathogens/19386688
Dataset
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Additional file 1 of Self-reported symptoms and health complaints associated with exposure to Ixodes ricinus-borne pathogens
Azagi, T. (Creator), Harms, M. (Creator), Swart, A. (Creator), Fonville, M. (Creator), Hoornstra, D. (Creator), Mughini-Gras, L. (Creator), Hovius, J. W. (Creator), Sprong, H. (Creator) & van den Wijngaard, C. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.19386688.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Self-reported_symptoms_and_health_complaints_associated_with_exposure_to_Ixodes_ricinus-borne_pathogens/19386688/1
Dataset