Research output per year
Research output per year
Personal profile
Research interests
The Grootjans Lab studies the interplay between the immune system and gastrointestinal cancers.
The lab has three major research lines:
1. Understanding how immune cell alterations in the background of chronic intestinal inflammation (inflammatory bowel disease) favor the development of colorectal cancer;
2. Finding novel immunomodulatory treatment targets for difficult-to-treat cancers such as peritoneal metastasized disease, by better understanding the tumor immune environment;
3. Uncovering the mechanisms driving immune-related adverse events of currently used immune-activating therapies (immune checkpoint inhibitors).
Specialisation
cancer immunology, peritoneal metastases, tumor immune environment, inflammatory bowel disease, colorectal cancer, gastric cancer
Related documents
Education/Academic qualification
PhD, PhD Life and death at the mucosal luminal interface: a new perspective on human intestinal ischemia-reperfusion, Maastricht University
2007 → 2011
Award Date: 2 Nov 2012
Master, Medical Doctor degree, Maastricht University
2001 → 2007
External positions
Junior PI, Oncode Institute
… → 31 Dec 2027
Keywords
- R Medicine (General)
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases
Lartey, D. A., Schilder, L. A., Zwezerijnen, G. J. C., D’Haens, G. R. A. M., Grootjans, J. & Löwenberg, M., 1 Apr 2025, In: Biomedicines. 13, 4, 775.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile125 Downloads (Pure) -
Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer
Saris, J., Li Yim, A. Y. F., Bootsma, S., Lenos, K. J., Franco Fernandez, R., Khan, H. N., Verhoeff, J., Poel, D., Mrzlikar, N. M., Xiong, L., Schijven, M. P., van Grieken, N. C. T., Kranenburg, O., Wildenberg, M. E., Logiantara, A., Jongerius, C., Garcia Vallejo, J. J., Gisbertz, S. S., Derks, S. & Tuynman, J. B. & 3 others, , 1 Dec 2025, In: Nat. Commun.. 16, 1, 3669.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile36 Downloads (Pure) -
The effect of Sphingosine-1-phosphate receptor modulator treatment on leukocyte subsets across different clinical indications: A systematic review
Nikolakis, D., Teichert, C., Grootjans, J., van de Sande, M. G. H. & D’Haens, G. R., 18 Dec 2025, In: Autoimmunity reviews. 24, 12, 103934.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile9 Downloads (Pure) -
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
Groen-Van Schooten, T. S., Franco Fernandez, R., Van Grieken, N. C. T., Bos, E. N., Seidel, J., Saris, J., Martínez-Ciarpaglini, C., Fleitas, T. C., Thommen, D. S., De Gruijl, T. D., Grootjans, J. & Derks, S., 2024, In: J. Immunother. Cancer. 12, 7Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile95 Downloads (Pure) -
Polyp size measurement during colonoscopy using a virtual scale: variability and systematic differences
van Bokhorst, Q. N. E., Houwen, B. B. S. L., Hazewinkel, Y., van der Vlugt, M., Beaumont, H., Grootjans, J., van Tilburg, A., Fockens, P., Bossuyt, P. M. M., Dekker, E., Adriaanse, M. P. M., Bastiaansen, B. A. J., van Beurden, Y. H., Bronzwaer, M. E. S., Hens, B. W. E., Hubers, L. M., Kramer, G. M., Lekkerkerker, S. J. & The SCALE EYE study group, 23 Jul 2024, (E-pub ahead of print) In: Endoscopy.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile43 Downloads (Pure)
Activities
- 1 Editorial activity
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Frontiers in immunology (Journal)
Grootjans, J. (Member of editorial board)
1 Jan 2024 → …Activity: Publication peer-review and editorial work › Editorial activity
Prizes
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Amsterdam Gastroenterology & Metabolism Talent development award
Grootjans, J. (Recipient), 2019
Prize: Other distinction
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