Research output per year
Research output per year
Personal profile
Specialisation
human immunology, innate immunology, mucosal immunology, epithelial immunology
Research interests
Jochem Bernink – Human Mucosal Immunology
In my lab we aim to contribute to a better understanding how mucosal homeostasis is established, maintained and restored following mechanic damage, irradiation damage or infectious insults in humans.
Towards this aim we develop molecular and cellular tools to dissect interactions between microbiome, mucus, epithelium, and (tissue-resident) immune cells, such as innate lymphoid cells (ILCs).
We will employ humanized immune system mouse models to functionally test our discoveries in vivo, and the physiological relevance of our discoveries is tested in a translational manner through our close collaboration with the department of gastroenterology.
Techniques involved are 2D and 3D organoid cultures, ex vivo cultures, Crispr/cas9 techniques, Flow cytometry, microscopy, etc.
Fingerprint
Dive into the research topics where Jochem Bernink is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Identification of human cytotoxic ILC3s
Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Spits, H. & Bernink, J. H., Apr 2021, In: European journal of immunology. 51, 4, p. 811-823 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile45 Downloads (Pure) -
CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease
Krabbendam, L., Heesters, B. A., Kradolfer, C. M. A., Haverkate, N. J. E., Becker, M. A. J., Buskens, C. J., Bemelman, W. A., Bernink, J. H. & Spits, H., 1 Dec 2021, In: Nature communications. 12, 1, 5841.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile28 Downloads (Pure) -
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
Bernink, J. H., Ohne, Y., Teunissen, M. B. M., Wang, J., Wu, J., Krabbendam, L., Guntermann, C., Volckmann, R., Koster, J., van Tol, S., Ramirez, I., Shrestha, Y., de Rie, M. A., Spits, H., Romero Ros, X. & Humbles, A. A., 1 Aug 2019, In: Nature immunology. 20, 8, p. 992-1003 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile87 Downloads (Pure) -
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
Bernink, J. H., Peters, C. P., Munneke, M., te Velde, A. A., Meijer, S. L., Weijer, K., Hreggvidsdottir, H. S., Heinsbroek, S. E., Legrand, N., Buskens, C. J., Bemelman, W. A., Mjösberg, J. M. & Spits, H., 2013, In: Nature immunology. 14, 3, p. 221-229Research output: Contribution to journal › Article › Academic › peer-review
-
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria
Bernink, J. H., Krabbendam, L., Germar, K., de Jong, E., Gronke, K., Kofoed-Nielsen, M., Munneke, J. M., Hazenberg, M. D., Villaudy, J., Buskens, C. J., Bemelman, W. A., Diefenbach, A., Blom, B. & Spits, H., 2015, In: Immunity. 43, 1, p. 146-160Research output: Contribution to journal › Article › Academic › peer-review