Projects per year
Personal profile
Research interests
Intestinal homeostasis. Stem cell biology, tumor genetics, Translational control in the intestine. infections in immunocompromised patients.
specialisation
internal medicine with subspecialisations acute medicine and hematology.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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ER-stress and Grp78 during intestinal carcinogenesis
Heijmans, J. (Principal investigator) & Packham, G. G. (Principal investigator)
15/02/2012 → 15/05/2014
Project: Research
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Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity
Smit, W. L., Spaan, C. N., de Boer, R. J., Ramesh, P., Garcia, T. N. M., Meijer, B. J., Vermeulen, J. L. M., Lezzerini, M., MacInnes, A. W., Koster, J., Medema, J. P., van den Brink, G. R., Muncan, V. & Heijmans, J., 13 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 41, p. 25560-25570 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access52 Citations (Scopus) -
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
Heijmans, J., van Lidth de Jeude, J. F., Koo, B.-K., Rosekrans, S. L., Wielenga, M. C. B., van de Wetering, M., Ferrante, M., Lee, A. S., Onderwater, J. J. M., Paton, J. C., Paton, A. W., Mommaas, A. M., Kodach, L. L., Hardwick, J. C., Hommes, D. W., Clevers, H., Muncan, V. & van den Brink, G. R., 2013, In: Cell reports. 3, 4, p. 1128-1139Research output: Contribution to journal › Article › Academic › peer-review
228 Citations (Scopus) -
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
Spaan, C. N., Smit, W. L., van Lidth de Jeude, J. F., Meijer, B. J., Muncan, V., van den Brink, G. R. & Heijmans, J., 2019, In: Cell death & disease. 10, 7, 490.Research output: Contribution to journal › Article › Academic › peer-review
Open Access80 Citations (Scopus) -
Heterozygosity of chaperone GRP78 reduces intestinal stem cell regeneration potential and protects against adenoma formation
van Lidth de Jeude, J. F., Spaan, C. N., Meijer, B. J., Smit, W. L., Soeratram, T. T. D., Wielenga, M. C. B., Florien Westendorp, B., Lee, A. S., Meisner, S., Vermeulen, J. L. M., Wildenberg, M. E., van den Brink, G. R., Muncan, V. & Heijmans, J., 2018, In: Cancer research. 78, 21, p. 6098-6106Research output: Contribution to journal › Article › Academic › peer-review
14 Citations (Scopus) -
Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells
van Lidth de Jeude, J. F., Meijer, B. J., Wielenga, M. C. B., Spaan, C. N., Baan, B., Rosekrans, S. L., Meisner, S., Shen, Y. H., Lee, A. S., Paton, J. C., Paton, A. W., Muncan, V., van den Brink, G. R. & Heijmans, J., 2017, In: Oncogene. 36, 24, p. 3397-3405Research output: Contribution to journal › Article › Academic › peer-review
29 Citations (Scopus)