Within my research group we explore cellular components that are involved in maintenance of vascular homeostasis. Our research on “Cellular Haemostasis” aims to integrate biochemical and clinical research in the area of thrombosis and hemostasis, vascular biology as well as molecular and cellular immunology. Through this approach we aim to increase our current knowledge on the interactions of hemostatic proteins with the vessel wall as well as the immune system. We expect that studies in this area will result in novel therapeutic approaches for patients with vascular or haematological disorders. Our current focus of research comprises the auto-immune disorder thrombotic thrombocytopenic purpura (TTP). Within the context of an EU funded consortium we are exploring the mechanisms contributing to the onset of autoimmunity in patients with TTP. In parallel we are designing gene therapy and gene correction based strategies for bleeding disorders that include Von Willebrand disease, hemophilia A as well as rare bleeding disorders.