Personal profile
Research interests
My PhD project focuses on using PET/CT imaging as a predictive biomarker for response to
immunotherapy, and on evaluating novel therapeutics such as nanoparticles or antibodydrug
conjugates using this technique. PET/CT imaging is a non-invasive tool that produces
qualitative as well as quantitative data on tumor uptake and biodistribution, while
simultaneously allowing for heterogeneity analysis and repetitive measurements.
Applying PET/CT imaging as a potential biomarker for immunotherapy requires a
translational approach and a close collaboration has been achieved within the Cancer Center
Amsterdam to match PET results to pathology and flow cytometry results.
Education/Academic qualification
Master, Master of Oncology, VUmc School of Medical Sciences, Amsterdam.
Award Date: 20 Jun 2018
Master, Geneeskunde, VUmc School of Medical Sciences, Amsterdam.
Award Date: 15 Aug 2017
Bachelor, Geneeskunde, VUmc School of Medical Sciences, Amsterdam.
Award Date: 26 Oct 2013
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Research output
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89Zr-mAb uptake interpretation requires the use of tissue to plasma ratios corrected for antibody catabolism
Huisman, M. C., Pouw, J. E. E., Golla, S. S. V., Huglo, D., Morschhauser, F., Zijlstra, J. M., Wijngaarden, J. E., Stavenga, M., Sebus, H. J., Slebe, M., Thiele, A., Vugts, D., Miedema, I. H. C., Zwezerijnen, G. J. C., Bahce, I., Menke-van der Houven van Oordt, C. W., Shah, D. K., Jauw, Y. W. S. & Boellaard, R., 1 Dec 2025, In: EJNMMI research. 15, 1, 122.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile39 Downloads (Pure) -
A minimal physiologically-based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti-LAG-3 monoclonal antibody
Michelet, R., Petersson, K., Huisman, M. C., Menke-van der Houven van Oordt, C. W., Miedema, I. H. C., Thiele, A., Montaseri, G., Pérez-Pitarch, A. & Busse, D., Mar 2025, In: CPT: Pharmacometrics and Systems Pharmacology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure) -
Drug release from docetaxel-entrapped core-crosslinked polymeric micelles: A population pharmacokinetic modelling approach based on clinical data
Rietveld, P. C. S., Koolen, S. L. W., Zeiser, S., Rijcken, C. J. F., van Noort, M., van Eerden, R. A. G., Atrafi, F., Miedema, I. H. C., van Oordt, C. W.M.-V. D. H., Koch, B. C. P., Mathijssen, R. H. J., Snelder, N. & Sassen, S. D. T., 1 May 2025, In: Biomedicine and Pharmacotherapy. 186, 118028.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile87 Downloads (Pure) -
Circulating T cell status and molecular imaging may predict clinical benefit of neoadjuvant PD-1 blockade in oral cancer
Wondergem, N. E., Miedema, I. H. C., van de Ven -van Balken, R., Zwezerijnen, G. J. C., de Graaf, P., Karagozoglu, K. H., Hendrickx, J. J., Eerenstein, S. E. J., Bun, R., Mulder, D. C., Voortman, J., Boellaard, R., Windhorst, A. D., Hagers, J. P., Peferoen, L. A. N., de Gruijl, T. D., Bloemena, E., Brakenhoff, R. H., Leemans, C. R. & Menke-van der Houven van Oordt, C. W., 22 Jul 2024, In: Journal for immunotherapy of cancer. 12, 7, e009278.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile39 Downloads (Pure) -
Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18F-BMS986192 PET: pooled analysis of data from four solid tumor types.
Miedema, I. H. C., Pouw, J. E. E., Kwakman, A., Zwezerijnen, G. J. C., Huisman, M. C., Timmer, F. E. F., van de Ven, R., de Gruijl, T. D., Hospers, G. A. P., de Langen, A. J. & Menke-van der Houven van Oordt, C. W., 17 Jun 2024, In: Journal for immunotherapy of cancer. 12, 6, e008899.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile33 Downloads (Pure)