Personal profile
Research interests
T-cell based treatment strategies for chronic lymphocytic leukemia
Specialisation
T cell-based therapy in chronic lymphocytic leukemia
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Iris de Weerdt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
Lameris, R., Ruben, J. M., Iglesias-Guimarais, V., de Jong, M., Veth, M., van de Bovenkamp, F. S., de Weerdt, I., Kater, A. P., Zweegman, S., Horbach, S., Riedl, T., Winograd, B., Roovers, R. C., Adang, A. E. P., de Gruijl, T. D., Parren, P. W. H. I. & van der Vliet, H. J., 21 Mar 2023, In: Cell Reports Medicine. 4, 3, p. 100961 100961.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Downloads (Pure) -
A bispecific antibody antagonizes prosurvival CD40 signaling and promotes Vγ9Vδ2 T cell-mediated antitumor responses in human B-cell malignancies
de Weerdt, I., Lameris, R., Scheffer, G. L., Vree, J., de Boer, R., Stam, A. G., van de Ven, R., Levin, M.-D., Pals, S. T., Roovers, R. C., Parren, P. W. H. I., de Gruijl, T. D., Kater, A. P. & van der Vliet, H. J., 1 Jan 2021, In: Cancer immunology research. 9, 1, p. 50-61 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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A bispecific single-domain antibody boosts autologous Vg9Vd2-T cell responses toward CD1d in chronic lymphocytic leukemia
de Weerdt, I., Lameris, R., Ruben, J. M., de Boer, R., Kloosterman, J., King, L. A., Levin, M.-D., Parren, P. W. H. I., de Gruijl, T. D., Kater, A. P. & van der Vliet, H. J., 1 Mar 2021, In: Clinical cancer research. 27, 6, p. 1744-1755 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
NOVEL BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES
de Weerdt, I. (Inventor), Kater, A. P. (Inventor), de Gruijl, T. D. (Inventor), van der Lee, J. (Inventor) & Lameris, R. (Inventor), 13 Aug 2021, IPC No. A61K39/395 A61P35/04 C07K16/28, Patent No. CN113260629A, 26 Mar 2020, Priority date 19 Sept 2018Research output: Patent › Academic
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Functional Differences between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL
Hofland, T., de Weerdt, I., Endstra, S., Jongejan, A., Platenkamp, L., Remmerswaal, E. B. M., Moerland, P. D., ten Berge, I. J. M., Levin, M.-D., Kater, A. P. & Tonino, S. H., 2020, In: HemaSphere. 4, 2Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Downloads (Pure)