Personal profile
Research interests
Main activities (50/50)
• Tytgat Institute Research Quality management
The Tytgat Institute(TI) has an ISO15189 international accreditation for its research activities (Dutch Board of Accreditation, #M304) and is compliant with GcLP. For this I:
* design, implement and manage the TI quality system (QS)for research and preclinical studies
* am internal auditor and external auditor host
* perform Process analyses & Risk management
* validate processes, and coordinate equipment and assay validation
* perform Management Review of quality and general policy
* coordinate all aspects of TI Standard Operating Procedures (SOPs)
* train and inform TI staff on TI QS, auditing and risk management
* am SMART advisor for general management (Annual Plan, Action Plan, QPI’s)
* am Quality manual author
• (Pre)clinical Project Management:
The Tytgat Institute performs research and services for fee for external partners (pharma & CRO). For this I
* Manage all aspects of Tytgat Institute "external" preclinical studies (Set-up, Deliverables, Budget, Staff planning, Sample logistics, Data storage, Contracts and Invoicing)
* am Tytgat institute’s intermediair/contact for CRO and pharmaceutical companies
Contact:
www.tytgatresearchservices.com
Tel: +31205668832
Specialisation
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Safety and pharmacokinetics of SOR102, an oral bispecific inhibitor of TNF and interleukin-23 in healthy participants and patients with ulcerative colitis: a first-in-human, double-blind, randomised, placebo-controlled, phase 1 trial
Jairath, V., Danese, S., D'Haens, G. R., Feagan, B. G., Peyrin-Biroulet, L., Sands, B. E., Gaemers, I., Westfall, M., Terry, A. Q., Roberts, K. J., Barbat, S., Wedel, P., Benson, J. M. & Sattler, C., 1 Jan 2026, In: lancet. Gastroenterology & hepatology. 11, 1, p. 34-45 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn’s disease
Novak, G., Stevens, T., van Viegen, T., Bossuyt, P., Štabuc, B., Jeyarajah, J., Zou, G., Gaemers, I. C., McKee, T. D., Fu, F., Shackelton, L. M., Khanna, R., van den Brink, G. R., Sandborn, W. J., Feagan, B. G., Pai, R. K., Jairath, V., Vande Casteele, N. & D’Haens, G., Jun 2019, In: Alimentary pharmacology & therapeutics. 49, 11, p. 1401-1409Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Downloads (Pure) -
Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice
Gasparin, F. R. S., Carreño, F. O., Mewes, J. M., Gilglioni, E. H., Pagadigorria, C. L. S., Natali, M. R. M., Utsunomiya, K. S., Constantin, R. P., Ouchida, A. T., Curti, C., Gaemers, I. C., Elferink, R. P. J. O., Constantin, J. & Ishii-Iwamoto, E. L., 2018, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1864, 7, p. 2495-2509Research output: Contribution to journal › Article › Academic › peer-review
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Bile acid receptor agonists. INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice
de Oliveira, M. C., Gilglioni, E. H., de Boer, B. A., Runge, J. H., de Waart, D. R., Salgueiro, C. L., Ishii-Iwamoto, E. L., Oude Elferink, R. P. J. & Gaemers, I. C., 2016, In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1862, 11, p. 2054-2062Research output: Contribution to journal › Article › Academic › peer-review
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Erratum to "Quantitative Determination of Liver Triglyceride Levels with 3T 1H-MR Spectroscopy in Mice with Moderately Elevated Liver Fat Content" [Acad Radiol 21 (2014) 1446-1454]
Runge, J. H., Bakker, P. J., Gaemers, I. C., Verheij, J., Hakvoort, T. B. M., Ottenhoff, R. O., Stoker, J. & Nederveen, A. J., 1 Feb 2016, In: Academic radiology. 23, 2, p. 264 1 p.Research output: Contribution to journal › Erratum/Corrigendum › Academic