Personal profile
Research interests
Patients with severe hemophilia A can be effectively treated by intravenous administration of the deficient coagulation factor VIII (FVIII). However, in about 25-35% of patients, treatment is complicated by the development of neutralizing alloantibodies, called inhibitors. Eradication of inhibitors can be achieved by repeated administration of high-dose therapeutic FVIII, called immune tollerance induction (ITI). Unfortunately, this approach is only effective in about 70% of patients.
GO ITI Study Genetic determinants of the Outcome of Immune Tolerance Induction therapy in patients with severe hemophilia A and inhibitors.
The aim of this study is to identify genetic determinants that are associated with successful immune tolerance induction in patients with hemophilia A and inhibitors.
GRIP Study The role of Fc Gamma Receptors in Immune tolerance to factor VIII Protein.
This project aims to determine how the interaction of FVIII immune complexes with FcyRs directs the response of dendritic cells.
Specialisation
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Large deletions in the F8 gene predict immune tolerance induction failure in people with severe hemophilia A
Oomen, I., Abdi, A., Broer, L., Camelo, R. M., Callado, F. B. M. R. A., Carvalho, L. E. M., Calcaterra, I. L., Carcao, M., Castaman, G., Eikenboom, J. C. J., Fischer, K., Franco, V. K. B., Geissler, J., Kuijpers, T. W., Leebeek, F. W. G., Lillicrap, D., Lorenzato, C. S., Mancuso, M. E., Matino, D. & di Minno, M. N. D. & 9 others, , 1 Oct 2025, In: Research and practice in thrombosis and haemostasis. 9, 7, 103212.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure) -
Getting grip on tolerance: Antibodies and how to get rid of them
Oomen, I., 2024, 247 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
-
Prediction of the chance of successful immune tolerance induction in persons with severe hemophilia A and inhibitors: a clinical prediction model
Oomen, I., Abdi, A., Camelo, R. M., Callado, F. B. M. R. A., Carvalho, L. E. M., Calcaterra, I. L., Carcao, M., Castaman, G., Eikenboom, J. C. J., Fischer, K., Franco, V. K. B., Heymans, M. W., Leebeek, F. W. G., Lillicrap, D., Lorenzato, C. S., Mancuso, M. E., Matino, D., di Minno, M. N. D., Mohseny, A. B. & Oldenburg, J. & 4 others, , 1 Oct 2024, In: Research and practice in thrombosis and haemostasis. 8, 7, 102580.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Downloads (Pure) -
The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A
Oomen, I., Verhagen, M., Miranda, M., Allacher, P., Beckers, E. A. M., Blijlevens, N. M. A., Bom, J. G. V. D., Coppens, M., Driessens, M., Eikenboom, J. C. J., Fijnvandraat, K., Hassan, S., van Heerde, W. L., Hooimeijer, H. L., Jansen, J. H., Kaijen, P., Leebeek, F. W. G., Meijer, D., Paul, H. & Rijpma, S. R. & 6 others, , 2024, In: Frontiers in immunology. 15, 1355813.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Downloads (Pure) -
Determinants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis
International Genetic and clinical determinants of the Outcome of Immune Tolerance Induction (GO-ITI) study group, 1 Jan 2023, In: Research and practice in thrombosis and haemostasis. 7, 1, p. 100020 100020.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Downloads (Pure)