Personal profile
Research interests
Enthusiastic clinical epidemiologist with a passion for translational research. Affiliated at the department of Epidemiology and Data Science (EDS) at the Amsterdam UMC, and my projects are embedded at the CIMM (Center for Infection & Molecular Medicine), a translational laboratory in the Amsterdam UMC-location AMC hospital. The focus of my current projects involves 1) critically ill patients in the intensive care who acquire infections and/or develop acute kidney injury, and 2) improving outcomes of kidney transplanted patients. Here I apply epidemiological analyses linking clinical data with molecular data, such as genomic information, messenger RNAs, lipids, and metabolites. With profiling the immune system in critically ill patients, I explore heterogeneity of treatment effects (HTE). Next to this, I use causal inference methods to address time-varying confounding for acquiring complications during hospital stay. On these topics, I co-supervise several PhD students (as co-promotor). I hold personal grants from the Dutch Kidney Foundation.
Specialisation
Clinical epidemiology, Bioinformatics, Kidney transplantation, Sepsis, Acute kidney injury, Intensive care medicine
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Collaborations and top research areas from the last five years
Research output
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A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort
Vergouwe, M., Birnie, E., van Veelen, S., Biemond, J. J., Appelman, B., Peters-Sengers, H., de Bree, G. J., behalf of the TURN-COVID Study Group & van Ittersum, F. J., 1 Feb 2025, In: Open Forum Infect. Dis.. 12, 2Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile64 Downloads (Pure) -
Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development
van Amstel, R. B. E., Rademaker, E., Kennedy, J. N., Bos, L. D. J., Peters-Sengers, H., Butler, J. M., Bruse, N., Dongelmans, D. A., Kox, M., Vlaar, A. P. J., van der Poll, T., Cremer, O. L., Seymour, C. W. & van Vught, L. A., 1 Dec 2025, In: Critical Care. 29, 1, 58.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Downloads (Pure) -
Cytomegalovirus reactivation and the host immune response in patients with sepsis
de Brabander, J., Ong, D. S. Y., Cremer, O. L., Bos, L. D. J., Peters-Sengers, H. & van der Poll, T., 1 Dec 2025, In: The Journal of Infection. 91, 6, p. 106657 1 p., 106657.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients
Steenvoorden, T. S., de Kruijf, K. C., Appelman, B., Moggre, B., Bos, L. D. J., Vlaar, A. P. J., Douma, R. A., Uhel, F., Kers, J., Oppelaar, J. J., van Vught, L. A., Beudel, M., Elbers, P. W. G., Joost Wiersinga, W., van der Poll, T., Vogt, L., The Amsterdam UMC COVID-19 Biobank Study Group & the CovidPredict Study Group, 13 Mar 2025, In: Critical care explorations. 7, 3Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Klawitter, F., Hackenberg, J., Danckert, L., Bertsche, A., Petzold, A., Smith, H. A. B., Ely, E. W., Spang, C., Bajorat, R., Fischer, D.-C., Klinkmann, G., Körmann-Günther, A., Fleischmann, R., Heslegrave, A., Zetterberg, H., Peters-Sengers, H. & Ehler, J., 1 Dec 2025, In: Scientific reports. 15, 1, 43492.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Downloads (Pure)
Prizes
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Dutch PhD Thesis 2nd price 2018 in field of Nephrology
Peters-Sengers, H. (Recipient), 2019
Prize › Academic
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