Personal profile
Research interests
I'm a postdoctoral Researcher at Amsterdam UMC in the field of immunometabolism. My research interest are the metabolic fuels and pathways that support function (and dysfunction) of B and T cells in hematological malignancies. In our group, we use this knowledge to uncover new therapeutic targets and improve T-cell based therapies in these diseases. My current focus is on chronic lymphocytic leukemia.
Specialisation
cancer immunology, metabolism, CLL, metabolomics, extracellular flux analysis
Related documents
Education/Academic qualification
PhD, Exploring the regulation and function of TIGAR in cancer cells
1 Jan 2015 → 5 Jul 2019
Award Date: 5 Jul 2019
Master, Biomedical Sciences, Basic and Translational Cancer Research, Barcelona - Universityersitat de Barcelona
Sept 2013 → Jul 2014
Bachelor, Biomedical Sciences, Barcelona - Universityersitat de Barcelona
Sept 2009 → Sept 2013
External positions
Visiting PhD student, Beatson Institute for Cancer Research
… → Jul 2016
Researcher and Teaching Assistant, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona
… → Oct 2020
PhD student Biomedical Sciences Program, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona
… → Jul 2019
Keywords
- QR180 Immunology
- QP Physiology
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Research output
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Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment
Chen, Z., Simon-Molas, H., Cretenet, G., Valle-Argos, B., Smith, L. D., Forconi, F., Schomakers, B. V., van Weeghel, M., Bryant, D. J., van Bruggen, J. A. C., Peters, F. S., Rathmell, J. C., van der Windt, G. J. W., Kater, A. P., Packham, G. & Eldering, E., 11 Aug 2022, In: Blood. 140, 6, p. 630-643 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies
Montironi, C., Chen, Z., Derks, I. A. M., Cretenet, G., Krap, E. A., Eldering, E. & Simon-Molas, H., 17 May 2024, In: iScience. 27, 5, p. 109640 109640.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Downloads (Pure) -
Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia
Jacobs, C. F., Peters, F. S., Camerini, E., Cretenet, G., Rietveld, J., Schomakers, B. V., van Weeghel, M., Hahn, N., Verberk, S. G. S., van den Bossche, J., Langeveld, M., Kleijwegt, F., Eldering, E., Zelcer, N., Kater, A. P. & Simon-Molas, H., May 2025, In: Cellular & molecular immunology. 22, 5, p. 485-500 16 p., 5932.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Downloads (Pure) -
Metabolic Profiling of Tumor and Immune Cells Integrating Seahorse and Flow Cytometry
Goedhart, N. B. & Simon-Molas, H., 2025, Methods in Molecular Biology. Humana Press Inc., Vol. 2930. p. 103-126 24 p. (Methods in Molecular Biology; vol. 2930).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
Activities
- 1 Educational contribution
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T-cell metabolism in Master's course ‘Cutting edge Immunology: from Chemistry to Metabolism’, LUMC.
Simon Molas, H. (Participant)
2022 → …Activity: Educational contribution / Supervising student theses, products › Educational contribution › Educational