Personal profile
Research interests
My research focuses on the development of next generation birch pollen immunotherapy. The main goals are improvement of the efficacy and reduction of side effects by using nano delivery systems and novel adjuvants to target the antigen presenting cells of the immune system. These cells have been shown to play a crucial role in establishing adaptive immunity and skewing an existing allergic Th2 response to a tolerant Th1/Treg response.
Specialisation
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Collaborations and top research areas from the last five years
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Advancements in molecular and translational allergology: Safety and immunogenicity of chemically modified peanut allergens and nanoparticle-based delivery system
Warmenhoven, H. J. M., 2024, 213 p.Research output: PhD Thesis › Phd-Thesis - Research and graduation internal
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IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens
Warmenhoven, H. J. M., Hulsbos, L., Dreskin, S. C., Akkerdaas, J. H., Versteeg, S. A. & van Ree, R., Aug 2023, In: Journal of allergy and clinical immunology. 152, 2, p. 436-444.e6Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
Immunotherapeutic compositions and adjuvants
van Ree, R. (Inventor), Warmenhoven, H. J. M. (Inventor) & Leboux, R. J. T. (Inventor), 17 Nov 2023, IPC No. A61K39/00 A61K39/35 A61P37/00, Patent No. NL2031833B1, 16 Nov 2023, Priority date 11 May 2022Research output: Patent › Academic
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Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model
van Strien, J., Warmenhoven, H., Logiantara, A., Makurat, M., Aglas, L., Bethanis, A., Leboux, R., van Rijt, L., MacKay, J. A., van Schijndel, J. W., Schneider, G., Olsthoorn, R., Jiskoot, W., van Ree, R. & Kros, A., 6 Oct 2022, In: Frontiers in immunology. 13, 1006776.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure) -
Chemically modified peanut extract shows increased safety while maintaining immunogenicity
van der Kleij, H. P. M., Warmenhoven, H. J. M., van Ree, R., Versteeg, S. A., Pieters, R. H. H., Dreskin, S. C., Knulst, A. C., Hoffen, E. V., Opstelten, D. J. E., Koppelman, S. J. & Smit, J. J., 2019, In: Allergy. 74, 5, p. 986-995Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure)